Recurrence following curative resection for gastric carcinoma

Yoo, Chai H.; Noh, Sung Hoon; Shin, Dong Woo; Choi, Seung Ho; Min, Jin Sik

doi:10.1046/j.1365-2168.2000.01360.x

Cited by 633 publications

(514 citation statements)

References 25 publications

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“…The major feature of recurrence in GC patients is intraabdominal spread 13. Liver is the most common site of hematogenous metastasis of GC 14, 15.…”

Section: Introductionmentioning

confidence: 99%

Frequency and clinicopathological features of metastasis to liver, lung, bone, and brain from gastric cancer: A SEER‐based study

et al. 2018

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The hematogenous metastatic pattern of gastric cancer (GC) was not fully explored. Here we analyzed the frequency and clinicopathological features of metastasis to liver, lung, bone, and brain from GC patients. Data queried for this analysis included GC patients from the Surveillance, Epidemiology, and End Results Program database from 2010 to 2014. All of statistical analyses were performed using the Intercooled Stata 13.0 (Stata Corporation, College Station, TX). All statistical tests were two‐sided. Totally, there were 19 022 eligible patients for analysis. At the time of diagnosis, there were 7792 patients at stage IV, including 3218 (41.30%) patients with liver metastasis, 1126 (14.45%) with lung metastasis, 966 (12.40%) with bone metastasis and 151 (1.94%) with brain metastasis. GC patients with lung or liver metastasis have a higher risk of bone and brain metastasis than those without lung nor liver metastasis. Intestinal subtype had significantly higher rate of liver and lung metastasis, while diffuse type was more likely to have bone metastasis. Proximal stomach had significantly higher risk to develop metastasis than distal stomach. African‐Americans had the highest risk of liver metastasis and Caucasian had the highest prone to develop lung and brain metastasis. The median survival for patients with liver, lung, bone, and brain metastasis was 4 months, 3 months, 4 months and 3 months, respectively. It is important to evaluate the status of bone and brain metastasis in GC patients with lung or liver metastasis. Knowledge of metastatic patterns is helpful for clinicians to design personalized pretreatment imaging evaluation for GC patients.

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“…The major feature of recurrence in GC patients is intraabdominal spread 13. Liver is the most common site of hematogenous metastasis of GC 14, 15.…”

Section: Introductionmentioning

confidence: 99%

Frequency and clinicopathological features of metastasis to liver, lung, bone, and brain from gastric cancer: A SEER‐based study

et al. 2018

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“…As meticulous systematic lymphadenectomy has been the standard in cancer surgery for a long time in Japan, locoregional recurrences, especially recurrences to regional lymph nodes that should have been resected, have been considered regrettable and are actually infrequent. Thus, in Japan and Korea, the pattern of recurrence after curative surgery has long been peritoneal dissemination 28, 29. In addition, there are patients who suffer from peritoneal disease at their first clinical visit, especially among patients with linitis plastica type cancer 30, 31.…”

Section: Peritoneal Metastasismentioning

confidence: 99%

Surgery with curative intent for stage IV gastric cancer: Is it a reality of illusion?

Kodera

2018

Annals of Gastroent Surgery

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Gastric cancer with metastases outside of the regional lymph nodes is deemed oncologically unresectable. Nevertheless, some metastatic lesions are technically resectable by applying established surgical techniques such as para‐aortic lymphadenectomy and hepatectomy. At the time of compilation of the Japanese gastric cancer treatment guidelines version 4, systematic reviews were conducted to see whether it is feasible to make any recommendation to dissect both the primary and metastatic lesions with intent to cure, possibly as part of multimodality treatment. Long‐term survivors were found among carefully selected groups of patients both in prospective and retrospective studies. In addition, there is a growing list of publications reporting encouraging outcomes of gastrectomy conducted after exceptionally good response to chemotherapy, usually among patients who underwent R0 resection. This type of surgery is often referred to as conversion surgery. It is sometimes difficult to define a clear borderline between curative surgery scheduled after neoadjuvant chemotherapy and the conversion surgery. This review summarizes what we knew after the literature reviews conducted at the time of compiling the Japanese guidelines and in addition reflects some new findings obtained thereafter through clinical trials and retrospective studies. Metastases were divided into three categories based on the major metastatic pathways: lymphatic, hematogenous, and peritoneal. In each of these categories, there were findings that could provide hope for patients with metastatic disease. These findings implied that the surgical technique that we already use could become more useful upon further developments in antineoplastic agents and drug delivery.

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“…In Korea, gastric cancer is the most common malignancy and a major cause of cancer death despite improved prognosis as a result of early diagnosis, radical operations and the advancement of adjuvant therapy [1,[3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…However, many patients with gastric cancer present recurrent disease in the follow-up period even after complete resection [5]. When a recurrent tumor develops in the remnant stomach after subtotal gastrectomy, treatments such as chemotherapy and an additional operation with curative intent can be offered.…”

Section: Introductionmentioning

confidence: 99%

“…When a recurrent tumor develops in the remnant stomach after subtotal gastrectomy, treatments such as chemotherapy and an additional operation with curative intent can be offered. However, despite advances in the management of recurrent gastric cancer, several studies have reported a poor prognosis for patients with recurrent gastric cancer [2,5,7,9,10]. Imaging modalities, including contrast-enhanced computed tomography (CECT) and endoscopy, have been used for the detection of gastric cancer recurrence [4,11,12].…”

Section: Introductionmentioning

confidence: 99%

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Significance of SUV on Follow-up F-18 FDG PET at the Anastomotic Site of Gastroduodenostomy after Distal Subtotal Gastrectomy in Patients with Gastric Cancer

Choi

Zeon

Kim

et al. 2011

Nucl Med Mol Imaging

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Purpose The aim of this study was to characterize the patterns of fluorodeoxyglucose (FDG) uptake on F-18 FDG positron emission tomography/computed tomography (FDG PET/CT) at the anastomotic site of gastroduodenostomy after distal subtotal gastrectomy in patients with gastric cancer. Methods From May 2007 to May 2010, two or more follow-up measurements using FDG PET/CT scans were done for 19 patients (11 men, 8 women; mean age, 62.0± 10.3 years) who underwent distal subtotal gastrectomy with gastroduodenostomy between February 2006 and March 2008 for detecting gastric cancer recurrence at our medical center. The FDG PET/CT images were retrospectively reviewed. Patients with local recurrence, regional nodal metastasis or distant metastasis on follow-up studies were excluded. CT and endoscopy were done within 1 month before or after the FDG PET/CT scan. Eight patients had two follow-ups of FDG PET/CT, and 11 patients had three follow-ups. The mean interval between surgery and the first follow-up FDG PET/CT was 12.9±0.8 months (n=19); between the first and second it was 12.3±1.0 months (n= 19); between the second and third it was 11.6±0.7 months (n=11). The F-18 FDG uptakes at the anastomotic site and fundus in the remnant stomach were measured by maximum standardized uptake value (SUVmax) using a region of interest technique.Results The SUVmax at the anastomotic site was significantly higher than that of the fundus on all series of first, second and third follow-up studies (3.3±1.1 vs. 2.1±0.7, p<0.001: 3.1±0.9 vs. 2.2±0.7, p=0.001: 3.0±0.6 vs. 2.1±0.7, p=0.006, respectively). The SUVmax for the anastomotic site and fundus, and SUVmax ratio for the anastomotic site over the fundus were not significantly different throughout the series. Conclusion The SUVmax at the anastomotic site is significantly higher than that of the fundus and does not decrease significantly over time. Therefore, the local recurrence of gastric cancer after surgery could not be definitely differentiated from physiologic uptake or postoperative inflammatory change.

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Recurrence following curative resection for gastric carcinoma

Abstract: The risk factors for each recurrence pattern and timing of gastric cancer can be predicted by the clinicopathological features of the primary tumour. Since the results of treatment remain dismal, studies of perioperative adjuvant therapy in an attempt to reduce recurrence are warranted.

Cited by 633 publications

References 25 publications

Frequency and clinicopathological features of metastasis to liver, lung, bone, and brain from gastric cancer: A SEER‐based study

Frequency and clinicopathological features of metastasis to liver, lung, bone, and brain from gastric cancer: A SEER‐based study

Surgery with curative intent for stage IV gastric cancer: Is it a reality of illusion?

Significance of SUV on Follow-up F-18 FDG PET at the Anastomotic Site of Gastroduodenostomy after Distal Subtotal Gastrectomy in Patients with Gastric Cancer

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