Recurrence Dynamics for Non–Small-Cell Lung Cancer: Effect of Surgery on the Development of Metastases

Abstract

Recurrence dynamics of resected early-stage NSCLC displays a multipeak pattern, which supports the hypothesis of a metastasis growth model previously described for early-stage breast cancer. The model assumes both cellular and micrometastatic tumor dormancy and a transient phase of acceleration of metastatic growth following surgical excision of the primary tumor.

Prognosis and predictors of site of first metastasis after definitive radiation therapy for non-small cell lung cancer

“…Finally, factors predictive of first DM within prognostically unfavorable sites were nonsquamous histology for liver and a delay between diagnoses and RT and advanced initial stage for bone (Table 2). Our observed frequency of DM failure (42%) is consistent with that presented in other studies assessing treated with definitive radiation (ranging 33-59%) [1][2][3] and higher than those assessing definitive surgical management (range 23-42%) [16][17][18]. Predictors of DM after definitive treatment for NSCLC have been elucidated in a number of reports.…”

Reconstruction of the natural history of metastatic cancer and assessment of the effects of surgery: Gompertzian growth of the primary tumor

“…Minimization of functional L required a considerable numerical effort. The main difficulties were threefold: (1) relative flatness of the global minimum with respect to variation of some of the model parameters; (2) discontinuity of functional L as function of parameter A at all observed volumes of metastases; and (3) extremely large values of the integrand in formulas (13), (16) and (18). To overcome the latter difficulty, we used adaptive scaling of the integrand by factors depending on model parameters.…”

Sevoflurane suppresses hypoxia-induced growth and metastasis of lung cancer cells via inhibiting hypoxia-inducible factor-1α

“…However, dissemination of tumor cells often occurs during the intraoperative period, which can be caused by surgery or anesthesia [3,4]. This contributes to recurrence and metastasis after lung cancer surgery [5,6].…”