Recurrence and prognosis in intrahepatic cholangiocarcinoma patients with different etiology after radical resection: a multi-institutional study

Li, Qi; Chen, Chen; Su, Jingbo; Qiu, Yinghe; Wu, Hong; Song, Tianqiang; Mao, Xianhai; He, Yu; Cheng, Zhangjun; Li, Jingdong; Zhai, Wenlong; Zhang, Dong; Geng, Zhimin; Tang, Zhaohui

doi:10.1186/s12885-022-09448-w

Cited by 9 publications

(6 citation statements)

References 44 publications

(37 reference statements)

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“…Our study indicated that ICC prognosis is worse with than without stones, which is consistent with the ndings from previous reports [9,10,11]. The reason for the worse prognosis of ICC with stones might be attributed to the gross growth type of ICC with stones, which is mostly PI and MF + PI.…”

Section: Discussionsupporting

confidence: 91%

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Modification of AJCC TNM staging for intrahepatic cholangiocarcinoma with hepatolithiasis: a multi-institutional retrospective study

He,

Liao,

Lai

et al. 2023

Preprint

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Background Intrahepatic cholangiocarcinoma (ICC) with stones has a worse long-term prognosis than without stones. The stone factor is not considered in the American Joint Committee on Cancer (AJCC) TNM staging system 8th edition. This research aimed to determine whether the presence of stones was associated with T, N, and M staging and to develop a revised staging approach for a more precise staging of ICC patients who also presented with stones. Methods 625 ICC patients who had radical resection at three tertiary institutions in Fujian Province, China, between 2012 and 2022 were retrospectively evaluated, and were divided into stone (n = 270) and non-stone groups (n = 355) based on whether combined with hepatolithiasis. In the stone group, overall survival (OS) data was used to develop a modified AJCC staging system called the hepatolithiasis TNM staging system (hlTNM). Both hlTNM and 8th edition AJCC staging were evaluated for their prognostic value in stone group through three-items multivariate analyses and estimated area under ROC curve (AUC). Results Postoperative survival was worse in stone group at the same TNM stage. Three-items multivariate analyses illustrated that hlTNM staging was more appropriate for prognostic assessment. In stone group, hlTNM staging system (AUC = 0.892) outperformed the AJCC staging system (AUC = 0.872) in predicting the 3-year OS. hlTNM staging method regularly outperformed the AJCC staging approach regarding time-dependent ROC curves, demonstrating more precise prognostic stratification. Conclusion hlTNM staging is more effective in directing physicians’ management of ICC patients with stones and increases the accuracy of OS prediction.

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Section: Discussionsupporting

confidence: 91%

“…This is especially true in the southeastern coastal region of China, where the percentage of cases with ICC combined with stones is nearly 50% [4,7,8]. When ICC is accompanied with stones, the prognosis is said to be poorer, according to several studies [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Modification of AJCC TNM staging for intrahepatic cholangiocarcinoma with hepatolithiasis: a multi-institutional retrospective study

He,

Liao,

Lai

et al. 2023

Preprint

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“…The generation of gastrointestinal motility is related to the slow-wave potential induced by interstitial cells of Cajal (ICCs). The change in the number or structure of ICCs is the key to gastrointestinal motility disorder, and the reduction in the c-kit gene may reflect the decrease in the number of ICCs [ 111 ]. It has been established that the decrease in plasma motilin content in FD patients is related to the decrease in gastric emptying capacity, gastric electrical rhythm disturbance, and antrum–pyloric–duodenal motor coordination disorder.…”

Section: Relationship Between Intestinal Flora and Fdmentioning

confidence: 99%

Research Progress for Probiotics Regulating Intestinal Flora to Improve Functional Dyspepsia: A Review

Shen,

Xie,

et al. 2024

Foods

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Functional dyspepsia (FD) is a common functional gastrointestinal disorder. The pathophysiology remains poorly understood; however, alterations in the small intestinal microbiome have been observed. Current treatments for FD with drugs are limited, and there are certain safety problems. A class of active probiotic bacteria can control gastrointestinal homeostasis, nutritional digestion and absorption, and the energy balance when taken in certain dosages. Probiotics play many roles in maintaining intestinal microecological balance, improving the intestinal barrier function, and regulating the immune response. The presence and composition of intestinal microorganisms play a vital role in the onset and progression of FD and serve as a critical factor for both regulation and potential intervention regarding the management of this condition. Thus, there are potential advantages to alleviating FD by regulating the intestinal flora using probiotics, targeting intestinal microorganisms. This review summarizes the research progress of probiotics regarding improving FD by regulating intestinal flora and provides a reference basis for probiotics to improve FD.

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“…Recurrence can occur in the resection margin, other intrahepatic sites, or extrahepatically (including lungs, peritoneum, lymph nodes, bone, and adrenal glands), with most recurrences occurring in the liver [ 19 , 64 , 66 ]. There is increasing evidence that aggressive treatment including re-resection may prolong survival [ 67 , 68 ]. A recent multi-institutional study by the Okayama Study Group of HBP surgery, consisting of 345 cases of ICC with 223 recurrences, found that surgical resection of recurrent masses showed a median survival time of 39.5 months, significantly better than those treated non-surgically [ 69 ].…”

Section: Recurrencementioning

confidence: 99%

Surgical Aspects of Intrahepatic Cholangiocarcinoma

Kupietzky¹,

Ariche²

2022

Cancers

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Intrahepatic cholangiocarcinoma (ICC) is a rare and aggressive malignancy. It originates from the bile ducts and is the second most common primary cancer of the liver. Surgery is considered the only curative treatment of ICC, offering the best chance for long-term survival. The purpose of this article is to review the available literature on ICC, with a focus on the various aspects of the surgical care in this potentially lethal malignancy.

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Recurrence and prognosis in intrahepatic cholangiocarcinoma patients with different etiology after radical resection: a multi-institutional study

Cited by 9 publications

References 44 publications

Modification of AJCC TNM staging for intrahepatic cholangiocarcinoma with hepatolithiasis: a multi-institutional retrospective study

Modification of AJCC TNM staging for intrahepatic cholangiocarcinoma with hepatolithiasis: a multi-institutional retrospective study

Research Progress for Probiotics Regulating Intestinal Flora to Improve Functional Dyspepsia: A Review

Surgical Aspects of Intrahepatic Cholangiocarcinoma

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