Recurrence after Radiotherapy for Gastric Mucosa-associated Lymphoid Tissue (MALT) Lymphoma with Trisomy 18

Ishikawa, Hisashi; Iwamuro, Masaya; Okada, Hiroyuki; Kita, Masahide; Kawahara, Yoshiro; Tanaka, Takehiro; Kondo, Eisei; Yoshino, Tadashi; Yamamoto, Kazuhide

doi:10.2169/internalmedicine.54.3784

Cited by 8 publications

(9 citation statements)

References 19 publications

(32 reference statements)

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“…Aneuploidy - most commonly trisomy 18, trisomy 3, or both - is frequently observed in t(11;18)(q21;q21)/ API2-MALT1 -negative MALT lymphoma ( 17 - 20 ). The presence of extra copies of MALT1 is significantly associated with the progression or relapse of lymphoma ( 21 , 22 ), and it is an independent prognostic factor for a worse event-free survival, as determined by a Cox multivariate analysis ( 21 ). Previous studies have suggested that numerical gains, such as trisomy 3 or 18, are associated with the high-grade transformation of MALT lymphoma ( 18 , 23 ).…”

Section: Discussionmentioning

confidence: 99%

The Diagnosis of Gastric Mucosa-associated Lymphoid Tissue Lymphoma by Flow Cytometry and Fluorescence <i>in situ</i> Hybridization of Biopsy Specimens

et al. 2018

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Mucosa-associated lymphoid tissue (MALT) lymphoma and reactive inflammatory lymphoid changes are frequently difficult to distinguish based on a routine histological differential diagnosis. We were unable to diagnose gastric MALT lymphoma histologically using specimens obtained by endoscopy, although a flow cytometry (FCM) analysis demonstrated clonality of neoplastic cells by separating cells by CD45 gating. Furthermore, a fluorescence in situ hybridization (FISH) analysis showed trisomy 18. We therefore diagnosed gastric MALT lymphoma with trisomy 18. We recommend that FCM and FISH analyses of biopsy specimens be considered for diagnosing gastric MALT lymphoma if this diagnosis is suspected based on endoscopic findings.

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Section: Discussionmentioning

confidence: 99%

The Diagnosis of Gastric Mucosa-associated Lymphoid Tissue Lymphoma by Flow Cytometry and Fluorescence <i>in situ</i> Hybridization of Biopsy Specimens

et al. 2018

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“…Regardless of the pathogeneses of the two diseases, the similarities in the endoscopic images observed in the present case and the case of plasmacytoma reported by Harada et al [ 6 ] may reflect common pathological features shared between the two cases, for example, proliferation of plasma cells. However, further studies are required to determine the macroscopic morphologies of gastric MALT lymphoma with increased plasma cell differentiation, as we had previously encountered another case of this disease, which showed a lack of gastric pits and the presence of abnormal vessels [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of gastric MALT lymphoma with plasma cell differentiation was made based on these pathological features. Fluorescence in situ hybridization (FISH) analysis for t(11;18)(q21;q21) translocation revealed no fusion genes of BIRC3-MALT1 , although extra copies of MALT1 were identified in 32.0% of the monocytoid cells ( Figure 4 ), indicating trisomy of chromosome 18 [ 2 , 7 ]. Chromosome banding of the bone marrow aspirate showed a normal karyotype of 46, XX, indicating no congenital chromosomal abnormalities.…”

Section: Case Reportmentioning

confidence: 99%

Gastric MALT Lymphoma with Increased Plasma Cell Differentiation Showing Unique Endoscopic Features

Iwamuro

Tanaka

Nishida

et al. 2018

Case Reports in Gastrointestinal Medicine

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A 62-year-old woman was diagnosed with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with increased plasma cell differentiation of the stomach. Esophagogastroduodenoscopy showed slightly elevated, whitish lesions in the gastric body. Magnifying endoscopic observation revealed that the gastric surface epithelium was swollen, but the structure was not destroyed or diminished. Elongated, tortuous vasculature was observed on the surface of the whitish lesions. The patient underwent eradication treatment for Helicobacter pylori, which resulted in complete remission. Although the appearance of abnormal vessels and the destruction of gastric epithelial structure are the typical features of gastric MALT lymphoma during magnifying endoscopy, the present case showed different features, which were rather similar to those observed in a previously reported case of gastric plasmacytoma. The current case indicates that magnifying endoscopic features are not uniform among gastric MALT lymphomas.

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“…Statistical analysis revealed that the time to recurrence was significantly shorter in patients with trisomy 18 than in those without trisomy 18 ( P = 0.05). We also reported a patient with gastric MALT lymphoma with trisomy 18 in whom only partial improvement was documented after eradication therapy for H. pylori , and lymphoma recurred in the stomach 16 months after radiotherapy[ 5 ]. On the other hand, Taji et al[ 17 ] retrospectively reviewed 13 patients with localized MALT lymphoma in the stomach, and reported that all patients with unresponsive or progressive disease had t(11;18) translocation or trisomy 3.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, we reported a case of gastric MALT lymphoma with trisomy 18[ 5 ]. In that case, although there were no fusion genes of API2-MALT1 , trisomy 18 was identified as extra copies of MALT1 , using a fluorescence in situ hybridization (FISH) analysis for t(11;18)(q21;q21)/ API2-MALT1 translocation, since MALT1 is located on chromosome 18q21.…”

Section: Introductionmentioning

confidence: 99%

Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of theMALT1gene

Iwamuro¹,

Takenaka²,

Nakagawa³

et al. 2017

WJG

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AIMTo identify the clinical features of gastric mucosa-associated lymphoid tissue (MALT) lymphoma with extra copies of MALT1.METHODSThis is a multi-centered, retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1 (Group A, n = 88), patients with t(11;18) translocation (Group B, n = 27), and patients with extra copies of MALT1 (Group C, n = 31). The clinical background, treatment, and outcomes of each group were investigated.RESULTSGroups A and C showed slight female predominance, whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A (69.3%), 22 in Group B (81.5%), and 21 in Group C (67.7%). Helicobacter pylori (H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B, 14 patients underwent radiotherapy alone, which resulted in lymphoma disappearance. Although the difference was not statistically significant, event-free survival in Group C tended to be inferior to that in Group A (P = 0.10).CONCLUSIONPatients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication, similar to patients without t(11;18) translocation or extra copies of MALT1.

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Recurrence after Radiotherapy for Gastric Mucosa-associated Lymphoid Tissue (MALT) Lymphoma with Trisomy 18

Cited by 8 publications

References 19 publications

The Diagnosis of Gastric Mucosa-associated Lymphoid Tissue Lymphoma by Flow Cytometry and Fluorescence <i>in situ</i> Hybridization of Biopsy Specimens

The Diagnosis of Gastric Mucosa-associated Lymphoid Tissue Lymphoma by Flow Cytometry and Fluorescence <i>in situ</i> Hybridization of Biopsy Specimens

Gastric MALT Lymphoma with Increased Plasma Cell Differentiation Showing Unique Endoscopic Features

Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of theMALT1gene

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