Rectal polypoid Inflammatory Myofibroblastic Tumor in 39-year-old liver transplant recipient with de-novo ulcerative colitis: A case report and literature review

Salisbury, Taylor; Laghari, Muhammad; Yoshida, Eric M.; Webber, Douglas

doi:10.1016/j.ehpc.2018.02.003

Cited by 1 publication

(5 citation statements)

References 19 publications

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“…No tumour cell staining is seen with CD117, CD34 and S100. The proliferation index is low in contrast to the soft tissue sarcomas, which may share fibroblastic morphology …”

Section: Inflammatory Myofibroblastic Tumourmentioning

confidence: 91%

“…Features favouring IMTs over IFPs include large size, infiltrative capacity and relative paucity of eosinophils. The spindle cell component is positive for vimentin, SMA and desmin . No tumour cell staining is seen with CD117, CD34 and S100.…”

Section: Inflammatory Myofibroblastic Tumourmentioning

confidence: 98%

“…Inflammatory myofibroblastic tumours are considered fibroblastic–myofibroblastic neoplasms of intermediate biological potential, with the propensity for local invasion, recurrence and, rarely, metastasis . Sigmoid and rectal tumours are extremely rare, affecting children and adults . Patients present with lower GI complaints or systemic symptoms such as anaemia or weight loss.…”

Section: Inflammatory Myofibroblastic Tumourmentioning

confidence: 99%

“…Patients present with lower GI complaints or systemic symptoms such as anaemia or weight loss. Endoscopic or radiological findings include submucosal polyps and masses that infiltrate the bowel wall from the perirectal fat or sigmoid mesocolon with consequent stricture formation . IMTs may therefore be mistaken for lymphoma, sarcoma or rectal carcinoma.…”

Section: Inflammatory Myofibroblastic Tumourmentioning

confidence: 99%

“…The characteristic histological features are of spindle cells with plump vesicular nuclei and ill‐defined cytoplasm associated with a plasma cell‐ or lymphocyte‐predominant inflammatory infiltrate . Mild nuclear pleomorphism and membrane irregularity may be seen.…”

Section: Inflammatory Myofibroblastic Tumourmentioning

confidence: 99%

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Spindle cell proliferations of the sigmoid colon, rectum and anus: a review with emphasis on perineurioma

Grech

Schofield

2020

Histopathology

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A wide range of spindle cell proliferations are found uncommonly in the sigmoid colon, rectum and anus. They usually present as polyps, and include reactive lesions and benign and malignant neoplasms which may be primary or metastatic. They are less frequently described in the literature compared to those in the upper gastrointestinal tract, and may be underdiagnosed. The widespread use of sigmoidoscopy in symptomatic patients and bowel cancer screening programmes means that histopathologists must be aware of, and adopt a logical approach to, diagnosing spindle cell proliferations in biopsy and polypectomy specimens. This is particularly relevant given the strong association of some mesenchymal polyps with hereditary cancer syndromes. This review article will focus on perineurioma and the recent debate in relation to its overlap with fibroblastic polyp. The clinical, endoscopic, histological and immunohistochemical features of spindle cell proliferations which should be considered in the differential diagnosis of perineurioma will be discussed. There is also a brief reference to malignant spindle cell tumours of diagnostic importance.

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“…No tumour cell staining is seen with CD117, CD34 and S100. The proliferation index is low in contrast to the soft tissue sarcomas, which may share fibroblastic morphology …”

Section: Inflammatory Myofibroblastic Tumourmentioning

confidence: 91%

Section: Inflammatory Myofibroblastic Tumourmentioning

confidence: 98%

Section: Inflammatory Myofibroblastic Tumourmentioning

confidence: 99%

Section: Inflammatory Myofibroblastic Tumourmentioning

confidence: 99%

Section: Inflammatory Myofibroblastic Tumourmentioning

confidence: 99%

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