Rectal metastasis from Breast cancer: A rare entity

Ng, Cho Ee; Wright, L.; Pieri, Andrew; Belhasan, Anas; Fasih, Tarannum

doi:10.1016/j.ijscr.2015.06.023

Cited by 7 publications

(15 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Isolated metastases to the bowel wall are rare but have been reported secondary to a wide range of malignancies, including breast cancer [2][3][4][5][6][7][8][9][10][11][12]. In fact, after melanoma, breast cancer is the second most common metastasis to the GI tract [2]. Lobular carcinoma is the most likely to metastasize to the GI tract, despite representing only a minority of breast cancers [8].…”

Section: Discussionmentioning

confidence: 99%

Case of Invasive Metastatic Breast Cancer Mimicking Crohn’s Disease

Rubin¹,

Bafford²,

Haac³

et al. 2019

GSCR

View full text Add to dashboard Cite

Background: A female patient with a history of stage IIB invasive lobular breast cancer presented with symptoms of partial small bowel obstruction and workup led to a presumptive diagnosis of Crohn’s disease. However, at the time of surgical intervention, she was found to have metastatic lobular breast cancer with carcinomatosis and metastases to the small and large intestines. Summary: Our patient presented at age 55 with intermittent nausea and vomiting, dyspepsia, altered bowel habits, and weight loss. She had a history of invasive lobular carcinoma of the right breast treated with right modified radical mastectomy followed by adjuvant chemoradiation and hormonal therapy 5 years earlier. She was thought to be in remission. Initial workup of her GI complaints was notable for thickening of the sigmoid colon and hepatic flexure on CT scan and stricturing and colitis in these areas on colonoscopy. Mucosal biopsies showed nonspecific active colitis. The patient was treated for a presumptive diagnosis of Crohn’s disease without significant improvement. She was eventually taken for surgery after presenting with a high-grade small bowel obstruction. On exploration, numerous additional small and large bowel strictures, some associated with intraluminal masses, were found and a small bowel resection and ileostomy performed. Pathology revealed metastatic invasive lobular breast carcinoma. Although isolated metastases to the bowel wall are rare, they have been reported secondary to a wide range of malignancies. Breast cancer, especially lobular carcinoma, is one of the most common tumors to metastasize to the GI tract and can present years after the primary cancer diagnosis. Therefore, the differential diagnosis for a patient with signs and symptoms of bowel obstruction and a history of lobular breast cancer should include metastatic disease. Conclusion: Metastatic cancer to the GI tract can mimic Crohn’s disease and should be on the differential in older patients with abdominal complaints, particularly those with a history of breast cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Case of Invasive Metastatic Breast Cancer Mimicking Crohn’s Disease

Rubin¹,

Bafford²,

Haac³

et al. 2019

GSCR

View full text Add to dashboard Cite

show abstract

“…The GI tract is a relatively uncommon site of metastasis for breast cancers, and accounts for less than 1% of all metastatic cases 4. Several papers have been published on gastric metastasis and their association with ILC of the breast 2 5.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies report spread to the rectum with only 14 cases found in a literature review in 2012 6. In many of these cases, including a further report in 2015,4 the lobular cell type has been implicated at histopathological diagnosis 3 8–12. Large bowel stenosis and stricture, as was evident on colonoscopy of our patient, has been described in several case reports and may be a reason for clinical presentation 4 6 11…”

Section: Discussionmentioning

confidence: 99%

Invasive lobular breast carcinoma metastasising to the rectum

Cherian

Qureshi²,

Cairncross

et al. 2017

BMJ Case Reports

View full text Add to dashboard Cite

Gastrointestinal (GI) metastasis from a primary breast carcinoma is uncommon, with the rectum being one of the least reported sites in the literature. We report a case of a 79-year-old woman who underwent treatment for an infiltrative lobular carcinoma of the right breast with nodal involvement, and 10 years later developed recurrence in the form of rectal metastasis. Spread to the GI tract is most commonly seen with lobular breast carcinomas. Any patient with a history of breast cancer presenting typically or atypically with abdominal symptoms or altered bowel habit should raise a high index of suspicion for recurrent or metastatic disease.

show abstract

“…Metastasis to the gastrointestinal (GI) tract is uncommon, mainly if breast is the primary site; clinical manifestations are usually non-specific with symptoms related to local factors and extension of the bowel involvement. [1][2][3][4][5][6][7][8][9] Breast cancer affects lymph nodes, bones, lungs, liver, brain, and soft tissues, but rectal spread is very rare. [2][3][4][5][6][7][8][9] Lobular carcinoma is a major subtype in GI implants with up to 18% of incidence.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9] Breast cancer affects lymph nodes, bones, lungs, liver, brain, and soft tissues, but rectal spread is very rare. [2][3][4][5][6][7][8][9] Lobular carcinoma is a major subtype in GI implants with up to 18% of incidence. 1,2,[4][5][6][7][8][9] The period between the primary tumor diagnosis and evidence of implants is variable and reported to be up to 30 years.…”

Section: Introductionmentioning

confidence: 99%

Rectal Metastases of Breast Carcinoma: A Case Report

et al. 2021

View full text Add to dashboard Cite

The scarcely reported hematogenous rectal metastases from breast cancer are rare and the diagnosis is challenging. They may be recognized before, concomitantly with, or after the diagnosis of the primary site of breast cancer. Invasive lobular cancer is the histological type more frequently described, and most of the affected patients have a late diagnosis. Tardive recognition is associated with poor outcomes, despite the management options. Endoscopic and imaging evaluations, mainly magnetic resonance studies, are useful, but the anatomopathological findings are mandatory to confirm the diagnostic hypothesis. We describe a middle-aged woman with advanced rectal metastases of unsuspected breast cancer found during the evaluation of manifestations due to intestinal implants. One must highlight long-term follow-up of breast cancers even if seeming in remission. The aim of this report is to enhance the suspicion index of primary health care workers.

show abstract

Rectal metastasis from Breast cancer: A rare entity

Cited by 7 publications

References 21 publications

Case of Invasive Metastatic Breast Cancer Mimicking Crohn’s Disease

Case of Invasive Metastatic Breast Cancer Mimicking Crohn’s Disease

Invasive lobular breast carcinoma metastasising to the rectum

Rectal Metastases of Breast Carcinoma: A Case Report

Contact Info

Product

Resources

About