Rectal lymphoma in ulcerative colitis treated with azathioprine

Tan, Chew; Wilson, Godfrey; Howat, J M; Shreeve, David R

doi:10.1097/00042737-200108000-00022

Cited by 14 publications

(9 citation statements)

References 20 publications

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“…We reviewed the clinicopathological data of 11 cases of DLBCL complicating UC published in the English literature, including our case, as shown in Table 1 [1,[3][4][5][6][7][8][9][10][11]. The age at diagnosis ranged from 20 to 73 (median, 55) years.…”

Section: Discussionmentioning

confidence: 99%

“…According to data found in PubMed between 2001 and 2019, only ten cases of diffuse large B-cell lymphoma (DLBCL) complicating UC, including one case of large B-cell lymphoma with unknown details, have been reported [1,[3][4][5][6][7][8][9][10][11]. Approximately half of these cases are closely related to the long-term usage of immunosuppressants (70%, 7/10 cases) and a very high rate of Epstein-Barr virus (EBV) infection (80%, 4/5 cases) and are classified as Oii-LPD.…”

Section: Introductionmentioning

confidence: 99%

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A case of iatrogenic immunodeficiency-associated colonic lymphoma complicating ulcerative colitis

et al. 2020

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Background: Ulcerative colitis (UC) is one of the major types of inflammatory bowel diseases and is associated with a significantly increased risk of not only lymphoproliferative disorders but also lymphomas, of which most cases are related to the long-term usage of immunosuppressants. Here, we demonstrate a very rare case of other iatrogenic immunodeficiency-associated colonic diffuse large B-cell lymphoma (Oii-DLBCL) complicating UC and rectal perforation. In addition, we reviewed the clinicopathological features of previous cases of DLBCL related to UC. Case presentation: A 68-year-old man was diagnosed with left-sided UC 26 months prior. Although he was followed by immunosuppressive therapy with azathioprine and infliximab, an emergency total proctocolectomy was performed due to rectal perforation. The resected specimen exhibited irregular wall thickening and elevated multinodular lesions extending from the mid-transverse colon to the rectum, measuring up to 52 cm in length. Histologically, the lesion was diagnosed as Oii-DLBCL and crypt abscess surrounded by mixed inflammatory cell was remained. Conclusion: Oii-DLBCL complicating UC with rectal perforation is extremely rare. Macro-and microscopic findings are important for early diagnosis of the lesion.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A case of iatrogenic immunodeficiency-associated colonic lymphoma complicating ulcerative colitis

et al. 2020

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“…Crohn's disease was the underlying cause in 42 lymphomas (20 non-Hodgkin's lymphomas and 22 Hodgkin's lymphomas) and UC in 16 lymphomas (10 non-Hodgkin’s lymphomas and 6 Hodgkin's lymphomas). Of the six cases of Hodgkin's lymphoma associated with UC, three had nodal disease while the other three had extranodal disease (two colon and one skin) 5–7. These data suggest that association of UC with Hodgkin's disease is very rare, with only few published case reports in the literature.…”

Section: Discussionmentioning

confidence: 99%

Hodgkin's lymphoma rectosigmoid in a patient with ulcerative colitis on long-term azathioprine therapy

Khuroo

2014

BMJ Case Reports

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Hodgkin's lymphoma complicating chronic ulcerative colitis is extremely rare. We report a case of extranodal Hodgkin's lymphoma involving rectosigmoid in a patient of chronic ulcerative colitis on long-term azathioprine. A 67-year-old man presented with extensive ulcerative colitis, on follow-up since September 2005. He received long-term steroids, mesalamine and azathioprine. Serial surveillance colonoscopic examinations and colonic biopsies were performed. Surveillance colonoscopy performed 8 years after the onset of disease showed multiple deep ulcers and nodular masses involving the rectum and sigmoid colon. Histological examination of rectosigmoid biopsies showed classic Hodgkin's disease. Azathioprine was withdrawn. He received mechlorethamine, vincristine, procarbazine and prednisone (MOPP) chemotherapy protocol and was planned for total colectomy in follow-up. We believe patients with ulcerative colitis on long-term azathioprine should be on vigil for development of lymphomas by protocol surveillance colonoscopic examinations and biopsies. The risk of lymphoma in such patients is small and outweighs the benefits of long-term azathioprine therapy.

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“…Shodai Mizuno 1) , Hiroharu Shinozaki 1) , Shouhei Fujita 1) , Yuichi Sasakura 1) , 1) and Kentaro Obara 2)…”

Section: Diffuse Large B-cell Lymphoma Occurring From the Rectum Diagunclassified

Diffuse Large B-cell Lymphoma Occurring from the Rectum Diagnosed by Rectal Perforation That Developed during Treatment of Ulcerative Colitis

Mizuno

Shinozaki

Fujita

et al. 2018

Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi

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Rectal lymphoma in ulcerative colitis treated with azathioprine

Cited by 14 publications

References 20 publications

A case of iatrogenic immunodeficiency-associated colonic lymphoma complicating ulcerative colitis

A case of iatrogenic immunodeficiency-associated colonic lymphoma complicating ulcerative colitis

Hodgkin's lymphoma rectosigmoid in a patient with ulcerative colitis on long-term azathioprine therapy

Diffuse Large B-cell Lymphoma Occurring from the Rectum Diagnosed by Rectal Perforation That Developed during Treatment of Ulcerative Colitis

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