Rectal leiomyosarcoma in association with ulcerative colitis: a rare condition with an unusual presentation

Singh, Probjot; Bello, Brian L.; Weber, Christopher R.; Umanskiy, Konstantin

doi:10.1007/s00384-014-1873-3

Cited by 17 publications

(18 citation statements)

References 4 publications

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“…The most common location of GI involvement in GISTS is in the stomach (55%), small intestine (29%), colon (2.9%), and rectum (2.7%) [11]. Furthermore, GI LMS mainly involves stomach followed by small intestines, rarely colon and rectum [12]. True LMS of the colon is such a rare disorder that there isn't enough description of its nature.…”

Section: Discussionmentioning

confidence: 99%

Two cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery: a case report and a review of literature

Bananzadeh

Mokhtari

Sohooli

et al. 2021

Preprint

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Background Leiomyosarcoma (LMS) of the colon is an unbelievably rare and highly invasive tumor arising from the muscularis propria of the gastrointestinal tract. After the introduction of the oncogenic role of KIT by immunohistochemistry (IHC), the reported cases of gastrointestinal leiomyosarcoma were limited. True LMS of the colon is such a rare disorder that there isn’t enough description of its nature. The classical colon LMS presents with a vast majority of non-specific symptoms including mild abdominal pain, fresh/obscure rectal bleeding, and weight loss. Case presentation: we experienced two extremely rare cases of colonic LMS. First patient was a 48-year-old man referred to our surgical outpatient clinic with mild intermittent abdominal pain and occasional rectal bleeding. After the initial investigation patient underwent colonoscopy that was suggestive of a large polypoid mass in 15 centimeters from the anal verge. Histopathology and Subsequent immunohistochemistry were in favor of LMS of sigmoid colon, and he underwent Laparoscopic anterior resection. The second patient was a 49-year-old man with 3-month history of fatigue, melena, and unintentional weight loss. Colonoscopy revealed a large circumferential mass in sigmoid colon 40 cm from the anal verge with the diagnosis of LMS. He underwent Laparoscopic left hemicolectomy. Conclusion: Herein, we reported two rare cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery. The tumors were surgically removed via laparoscopic approach. Overall, colonic LMS is a highly invasive neoplasm with poor oncologic outcome.

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Section: Discussionmentioning

confidence: 99%

Two cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery: a case report and a review of literature

Bananzadeh

Mokhtari

Sohooli

et al. 2021

Preprint

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“…While it has been found throughout the colon, it most commonly originates primarily from the sigmoid and transverse colon [ 4 , 5 ]. It is important to distinguish the diagnosis of LMS from other GI mesenchymal tumors, particularly GIST, as the two diseases have different treatments and prognoses [ 3 ]. The introduction of targeted therapies for GISTs contributed to the establishment of further criteria for describing leiomyosarcomas as a separate condition from GIST.…”

Section: Discussionmentioning

confidence: 99%

“…While the more commonly prevalent colon malignancies, particularly adenocarcinoma, have an increased incidence in patients with inflammatory bowel disease (IBD), sarcomas arising in this setting are quite rare. To our knowledge and by review of PubMed literature, only eight cases of associated sarcoma and IBD have been reported, including three cases of LMS in ulcerative colitis and five cases of sarcomas found in the setting of Crohn's disease [ 3 , 8 ]. There is however a relationship between malignancy and immunosuppressed patients.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, the best treatment for leiomyosarcoma of the colon is surgical resection. This is true for both those LMS cases that arise independently and those that occur in the setting of immunosuppression and/or IBD [ 3 , 5 ]. However, since these malignancies are often not detected until late, outcomes are poor, and there is only a 50–60% success rate.…”

Section: Discussionmentioning

confidence: 99%

“…LMS most commonly originates in the uterus, GI tract, and retroperitoneum. Within the GI tract, the stomach is the most common site followed by the small intestine, colon, and rectum [ 3 ]. LMS of the colon has such a low prevalence that there is a paucity of data describing the true demographic, clinical, or gross features of the disease.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary Leiomyosarcoma of the Colon: A Report of Two Cases, Review of the Literature, and Association with Immunosuppression for IBD and Rheumatoid Arthritis

Crystal

Korderas

Schwartzberg

et al. 2018

Case Reports in Surgery

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Primary leiomyosarcomas (LMS) of the colon are rare and aggressive neoplasms and have been infrequently reported in the literature. These tumors are more aggressive and have poorer prognoses than adenocarcinoma of the colon and are often mistaken as such on initial evaluation. While the former has a clear association with inflammatory bowel disease (IBD), this correlation is not known to exist with LMS and IBD. Nor is there a known link between LMS and the immunosuppression for IBD, despite the known association between malignancy and immunosuppression for other diseases. Due to the low prevalence of this disease entity, there is limited knowledge and literature on the approach to diagnosing and treating these neoplasms, especially in the setting of the aforementioned comorbidities. Here, we describe two cases of this rare entity, presenting in two different circumstances: one in the setting of immunosuppression for IBD and arthritis, with a synchronous urothelial carcinoma, and the second appearing as the source of an acute abdomen. Both diagnoses were established following pathologic analysis.

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Leiomyosarcoma of the rectum: A systematic review of recent literature

Annicchiarico,

Montali,

Baldinu

et al. 2023

Journal of Surgical Oncology

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Leiomyosarcomas (LMSs) are rare tumors originating from the muscular layer. We performed a literature review of cases of confirmed rectal leiomyosarcomas (rLMSs) to clarify the history of such an infrequent tumor arising at such an uncommon location. In this research local recurrence was related to poorly differentiated rLMS and no other association between recurrence and any criteria was found. Concerning overall survival (OS), rLMS patients developing recurrence presented shorter longevity compared with the group without.

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Rectal leiomyosarcoma in association with ulcerative colitis: a rare condition with an unusual presentation

Cited by 17 publications

References 4 publications

Two cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery: a case report and a review of literature

Two cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery: a case report and a review of literature

Primary Leiomyosarcoma of the Colon: A Report of Two Cases, Review of the Literature, and Association with Immunosuppression for IBD and Rheumatoid Arthritis

Leiomyosarcoma of the rectum: A systematic review of recent literature

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