Rectal function following prostate brachytherapy

Merrick, Gregory S.; Butler, Wayne M.; Dorsey, Anthony T.; Galbreath, Robert W.; Blatt, H J; Lief, Jonathan H.

doi:10.1016/s0360-3016(00)00698-2

Cited by 56 publications

(16 citation statements)

References 16 publications

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“…Other investigations have shown that men treated with combined EBRT and BT have worse HRQOL outcomes than those treated with either one alone. 4,16,38 That we included these subjects in our BT group may explain why our BT outcomes were slightly worse than published studies, especially with respect to bowel symptoms. 13,17 Newer EBRT protocols that apply a higher total radiation dose may further affect HRQOL results.…”

Section: Discussionmentioning

confidence: 40%

Quality of life after surgery, external beam irradiation, or brachytherapy for early‐stage prostate cancer

Litwin

Gore

Kwan

et al. 2007

Cancer

231

125

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BACKGROUND.The primary treatments for clinically localized prostate cancer confer equivalent cancer control for most patients but disparate side effects. In the current study, the authors sought to compare health‐related quality of life (HRQOL) outcomes after the most commonly used treatments.METHODS.A total of 580 men completed the Medical Outcomes Study Short Form‐36, the University of California‐Los Angeles (UCLA) Prostate Cancer Index, and the American Urological Association Symptom Index before and through 24 months after treatment with radical prostatectomy (RP), external beam radiation therapy (EBRT), or brachytherapy (BT).RESULTS.General HRQOL did not appear to be affected by treatment. Obstructive and irritative urinary symptoms were more common after BT (P < .001). Urinary control and sexual function were better after EBRT than BT (P < .001 and P = .02, respectively) and better after BT than RP (P < .001 and P = .01, respectively). Among potent men, recovery of sexual function was best after EBRT and was equivalent after bilateral nerve‐sparing surgery or BT. Sexual bother was more common than urinary or bowel bother after all 3 treatments. Bowel dysfunction was more common after EBRT or BT than RP (P < .001).CONCLUSIONS.In the current study, treatment for localized prostate cancer was found to differentially affect HRQOL outcomes. Urinary control and sexual function were better after EBRT, although bilateral nerve‐sparing surgery diminished these differences among potent men undergoing RP. BT caused more obstructive and irritative symptoms, while both forms of radiation caused more bowel dysfunction. These results may inform medical decision‐making in men with localized prostate cancer. Cancer 2007. © 2007 American Cancer Society.

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Section: Discussionmentioning

confidence: 40%

Quality of life after surgery, external beam irradiation, or brachytherapy for early‐stage prostate cancer

Litwin

Gore

Kwan

et al. 2007

Cancer

231

125

View full text Add to dashboard Cite

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“…Patient administered questionnaires have shown that there is relatively little long-term bowel dysfunction. 46 Pelvic pain and symptoms of prostatitis can occur but in our experience this is rare.…”

Section: Complicationsmentioning

confidence: 99%

“…45 Patients at risk of temporary urinary retention after brachytherapy include those urodynamically obstructed, with prostates 435 cm 3 , moderate to severe IPSS scores and postvoid residuals greater than 200 cm 3 pretreatment. 39 Proctitis is relatively uncommon, occurring in approximately 5% of cases 46,47 and in our experience has always resolved with conservative medication alone. It is more troublesome in patients with combined EBRT and brachytherapy as the rectal dose is increased.…”

Section: Complicationsmentioning

confidence: 99%

Iodine seed prostate brachytherapy: an alternative first-line choice for early prostate cancer

Langley

Laing

2004

Prostate Cancer Prostatic Dis

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This article on permanent iodine-125 seed prostate brachytherapy reviews the techniques, results, and patient selection issues for early prostate cancer. The longterm 10 y results of brachytherapy from Seattle, and their reproducibility in other centres both in the USA and UK are reported. The use of hormone therapy in brachytherapy and the value of combining external beam radiotherapy with a brachytherapy implant are discussed. Reviewed comparative data show the similarity of biochemical survival in patients treated with brachytherapy, radical prostatectomy, and external beam radiotherapy. The role of brachytherapy as a first-line treatment option for patients with prostate cancer is demonstrated.

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“…Long-term proctitis develops in 5% of men receiving brachytherapy as monotherapy and 15% receiving combined therapy [46]. The onset of rectal bleeding peaks at 8 months with an incidence of 4-11% [44,47] and usually resolves spontaneously. Importantly, half of the patients who had Grade 3 rectal toxicity (graded by a modified RTOG toxicity scale) had been biopsied before developing rectal ulceration [47], and together with the finding that anterior rectal biopsies (i.e.…”

Section: Gastrointestinal Symptomsmentioning

confidence: 99%

“…Some patients will experience transient rectal irritation manifested by more frequent and looser stools, and changes in bowel function, and this appears to be increased by adding EBRT [26,44]. The mechanism of radiation proctitis appears to be related to oedema and fibrosis of arterioles in the luminal crypts of the colonic mucosa [45].…”

Section: Gastrointestinal Symptomsmentioning

confidence: 99%

Health‐related quality of life after prostate brachytherapy

Miller

Theodorescu

2004

BJU International

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Brachytherapy for prostate cancer has become a widely used treatment. Increasingly, urologists are becoming conscious of quality‐of‐life issues relating to treatment. This mini‐review by authors from the University of Virginia looks at this important issue, reminding readers that patients are often willing to choose a treatment which will less certainly ensure a longer life‐expectancy, but which will more certainly guarantee a better quality of life.Other mini‐reviews in this section describe the technique and complications of transurethral surgery for bladder tumours, the mechanisms of vasculogenic erectile dysfunction after renal transplantation, and laparoscopic radical cystectomy and urinary diversion.

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Rectal function following prostate brachytherapy

Cited by 56 publications

References 16 publications

Quality of life after surgery, external beam irradiation, or brachytherapy for early‐stage prostate cancer

Quality of life after surgery, external beam irradiation, or brachytherapy for early‐stage prostate cancer

Iodine seed prostate brachytherapy: an alternative first-line choice for early prostate cancer

Health‐related quality of life after prostate brachytherapy

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