Rectal Carcinoid Tumors

Kwaan, Mary R.

doi:10.1001/archsurg.143.5.471

Cited by 119 publications

(41 citation statements)

References 13 publications

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“…About 80% of typical rectal carcinoid cases are 10 mm or less in size, restricted in submucosal layer with less metastasis, contributing to its favorable prognosis with 5-year survival rate estimated around 88.3% 7. For this reason, local treatment with endoscopic resection or minimal invasive surgery, rather than radical resection, is preferred in many cases 8,9,22,25-28. Rectal carcinoid of 10 mm or less in size, without lymphovascular, proper muscle invasion or lymph node metastasis, is reported to have good prognosis of around 98.9% to 100% of 5-year survival rate 6,21,22,29…”

Section: Discussionmentioning

confidence: 99%

Endoscopic Resection for Rectal Carcinoid Tumors: Comparision of Polypectomy and Endoscopic Submucosal Resection with Band Ligation

et al. 2012

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Background/AimsRectal carcinoid tumors, at diagnosis, are as small as 10 mm or less in about 80% of patients. These tumors are generally removed by endoscopic resection. The aim of this study was to compare treatment efficacy and safety between endoscopic submucosal resection with band ligation (ESMR-L) and conventional polypectomy.MethodsBetween January 2005 and September 2010, a total of 88 patients, who visited at Busan Paik Hospital and Kosin University Gospel Hospital for endoscopic resection of rectal carcinoid, were reviewed, retrospectively.ResultsThirty-three cases were treated by ESMR-L, and 55 cases by conventional polypectomy. There were no significant difference in the size of tumor between ESMR-L group and polypectomy group (6.02±2.36 vs. 6.49±3.24 mm, p=0.474). The rate of positive resection margin was significantly lower in ESMR-L group (2/33, 6.1%) than in polypectomy group (19/55, 34.5%; p=0.002). The rate of positive vertical resection margin, among others, was markedly lower in ESMR-L group (1/33, 3.0%) compared to polypectomy group (19/55, 34.5%; p<0.001).ConclusionsESMR-L, rather than conventional polypectomy, is a useful treatment option for removal of rectal carcinoid tumors less than 10 mm in diameter.

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Section: Discussionmentioning

confidence: 99%

Endoscopic Resection for Rectal Carcinoid Tumors: Comparision of Polypectomy and Endoscopic Submucosal Resection with Band Ligation

et al. 2012

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“…This finding coincides with multiple previous studies which have reported no recurrences after resection of tumors ≤1.0 cm, over a median follow-up period of up to 6.4 years and a cohort as large as 84 patients [13–15]. Alternatively, Kwaan et al reported 2 of 48 patients (4%) with a rectal carcinoid tumor <1.0 cm had distant metastatic recurrence discovered at 5 and 13 years after resection [12]. The initial management and follow-up surveillance of these 2 patients is unclear.…”

Section: Resultssupporting

confidence: 91%

Surveillance of Small Rectal Carcinoid Tumors in the Absence of Metastatic Disease

Murray

Sippel²,

Lloyd³

et al. 2012

Ann Surg Oncol

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Background The incidence of rectal carcinoids is rapidly increasing, typically presenting as small (<1.0 cm) localized tumors. While the evaluation of rectal carcinoids on presentation is well standardized, surveillance following resection has not been well established. Methods A prospective database documented patients with rectal carcinoids at our institution between January 1995 and September 2011. Information collected included patient and tumor characteristics, treatment method, surveillance schedule, recurrence, and survival. Results Twenty-eight patients with rectal carcinoid were identified. Ten patients were excluded for tumors >1 cm, known metastases, <6 months follow-up, or previous resection. The mean age of the remaining patients was 56±3 years and 61% were female. All patients were diagnosed on endoscopy, with 59% diagnosed incidentally on screening endoscopy. Treatment methods included endoscopic therapy (n=13, 72%), transanal excision (n=3, 17%), and transanal endoscopic microsurgery (n=1, 5.5%). One patient (5.5%) received no additional invasive therapy after diagnostic endoscopy. The mean tumor diameter was 4.6±0.5 mm. The average length of follow-up was 5.4±0.9 years, with a median number of 2 follow-up endoscopies (range 0–6). Two patients (11%) died within the follow-up period from non-carcinoid causes. Importantly, no surviving patients developed local or distant recurrence with up to 12.3 years of follow-up. Mean length of disease-free survival was 6.9±0.8 years. Conclusion Based on this experience, patients presenting with small (≤1.0 cm), non-metastatic rectal carcinoids are unlikely to develop local or distant recurrence after resection. Aggressive surveillance with repeat endoscopies or other imaging studies after resection may be unnecessary in this patient population.

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“…The primary tumor had been small and confined to the submucosa without any evidence of vascular involvement; recurrence of such a tumor with a long interval from curative surgery is quite rare (10,11). A case of liver metastasis 13 years after resecting a rectal NET smaller than 10 mm has been reported (12). Our case shows a longer time period from the primary operation to recurrence.…”

Section: Discussionmentioning

confidence: 99%

Recurrence 30 Years after Surgical Resection of a Localized Rectal Neuroendocrine Tumor

et al. 2017

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Localized small rectal neuroendocrine tumors (NETs) without any vascular involvement rarely metastasize, and their resection alone is considered curative. We herein report a case of localized rectal NET (10×8 mm) without vascular involvement. Although resected initially, it recurred as liver metastasis 30 years later. For rectal NETs smaller than 10 to 20 mm, surveillance for 12 months is considered sufficient. However, this case suggests that such tumors can recur even 30 years after curative resection. The interval of recurrence is the longest among reported cases.

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Rectal Carcinoid Tumors

Cited by 119 publications

References 13 publications

Endoscopic Resection for Rectal Carcinoid Tumors: Comparision of Polypectomy and Endoscopic Submucosal Resection with Band Ligation

Endoscopic Resection for Rectal Carcinoid Tumors: Comparision of Polypectomy and Endoscopic Submucosal Resection with Band Ligation

Surveillance of Small Rectal Carcinoid Tumors in the Absence of Metastatic Disease

Recurrence 30 Years after Surgical Resection of a Localized Rectal Neuroendocrine Tumor

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