Rectal burn caused by hot-water coffee enema

Sashiyama, Hiroshi; Hamahata, Yukihiro; Matsuo, Keigo; Akagi, Kazunari; Tsutsumi, Osamu; Nakajima, Yasuo; Takaishi, Yuko; Takase, Yasuo; Arai, Takehiro; Hoshino, Toshihiko; Tazawa, Akihiro; Fu, Kuang I.; Tsujinaka, Yasunobu

doi:10.1016/j.gie.2008.04.017

Cited by 12 publications

(9 citation statements)

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“…The documented potential risks of coffee enema include rectal burn induced by hot enema fluid [10, 11], proctocolitis [12, 13], polymicrobial enteric septicemia [14], electrolyte imbalance, or even death [15]. In addition, systemic adverse effects from colonic absorption of caffeine following a coffee enema are another issue that might be of concern to enema users or even mainstream physicians.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Caffeine following a Single Administration of Coffee Enema versus Oral Coffee Consumption in Healthy Male Subjects

Teekachunhatean

Tosri²,

Rojanasthien

et al. 2013

ISRN Pharmacology

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The objective of this study was to determine the pharmacokinetics of caffeine after single administration of a coffee enema versus coffee consumed orally in healthy male subjects. The study design was an open-label, randomized two-phase crossover study. Eleven healthy subjects were randomly assigned either to receive 500 mL of coffee enema for 10 minutes or to consume 180 mL of ready-to-drink coffee beverage. After a washout period of at least 10 days, all the subjects were switched to receive the alternate coffee procedure. Blood samples were collected immediately before and at specific time points until 12 hours after coffee administration in each phase. The mean caffeine content in both the coffee solution prepared for the coffee enema and the ready-to-drink coffee beverage was not statistically different. The C max and AUC of caffeine obtained from the coffee enema were about 3.5 times significantly less than those of the coffee consumed orally, despite having slightly but statistically faster T max. The t 1/2 of caffeine obtained following both coffee procedures did not statistically differ. In summary, the relative bioavailability of caffeine obtained from the coffee enema was about 3.5 times significantly less than those of the coffee consumed orally.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Caffeine following a Single Administration of Coffee Enema versus Oral Coffee Consumption in Healthy Male Subjects

Teekachunhatean

Tosri²,

Rojanasthien

et al. 2013

ISRN Pharmacology

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“…Among the 9 case reports, 3 were from the United States, [ 12 – 14 ] 5 were from Korea, [ 15 – 19 ] and 1 was from Japan. [ 20 ] The characteristics and results are summarized in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

The safety and effectiveness of self-administered coffee enema

et al. 2020

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Background: As the self-administration of coffee enema is being used as a mean of self-care for detoxication in various indications, it is important that evidence-based public health information is provided for effective and safe use. However, the evidence is so far rare. This systematic review was conducted to investigate the safety and effectiveness of self-administered coffee enema in a wide range of use, and to provide evidence about its benefits and risks. Methods: Relevant studies were retrieved from Ovid MEDLINE, Ovid Embase, the Cochrane Central Register of Controlled Trials, and the Cumulative Index to Nursing and Allied Health Literature; and also from oriental databases, KoreaMed, Korean Medical Database, Korean Studies Information Service System, National Discovery for Science Leaders, and Korea Institute of Science and Technology Information, Oriental Medicine Advanced Searching Integrated System, China National Knowledge Infrastructure, and Japan Science and Technology Information Aggregator. Considering self-administered coffee enema being used in a various indication, study population was not restricted. Any types of published studies that included outcomes of effectiveness and safety of self-administered coffee enema with or without comparators were eligible for this systematic review. Data on biomedical indications, patient-reported outcomes, and adverse events were collected. Descriptive analyses were planned because diverse health conditions and outcome variables did not allow for quantitative synthesis. Results: Nine case reports that describe adverse events were identified and included in the analysis. Of these, 7 recent ones reported colitis after self-administration, mentioning that the most plausible cause assumed was the coffee fluid itself, which contained numerous chemical substances. Two others reported more critical adverse events. All 9 case reports with acceptable quality of evidence warned against the self-administration of the procedure. No study that reports the effectiveness of coffee enema was found. Conclusions: Based on the evidences reviewed, this systematic review does not recommend coffee enema self-administration as a complementary and alternative medicine modality that can be adopted as a mean of self-care, given the unsolved issues on its safety and insufficient evidence with regard to the effectiveness.

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“…The majority of the complications previously reported for coffee enemas were cases of proctocolitis caused by thermal injury due to the administration of hot coffee [20,21,22,23]. Dehydration or electrolyte imbalances due to frequent enema use have also been reported [20].…”

Section: Discussionmentioning

confidence: 99%

Coffee Enema for Preparation for Small Bowel Video Capsule Endoscopy: A Pilot Study

et al. 2014

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Coffee enemas are believed to cause dilatation of bile ducts and excretion of bile through the colon wall. Proponents of coffee enemas claim that the cafestol palmitate in coffee enhances the activity of glutathione S-transferase, an enzyme that stimulates bile excretion. During video capsule endoscopy (VCE), excreted bile is one of the causes of poor preparation of the small bowel. This study aimed to evaluate the feasibility and effect of coffee enema for preparation of the small bowel during VCE. In this pilot study, 17 of 34 patients were assigned to the coffee enema plus polyethylene glycol (PEG) 2 L ingestion group, whereas the 17 remaining control patients received 2 L of PEG only. The quality of bowel preparation was evaluated in the two patient groups. Bowel preparations in the proximal segments of small bowel were not differ between two groups. In the mid and distal segments of the small intestine, bowel preparations tend to be better in patients who received coffee enemas plus PEG than in patients who received PEG only. The coffee enema group did not experience any complications or side effects. Coffee enemas may be a feasible option, and there were no clinically significant adverse events related to coffee enemas. More prospective randomized studies are warranted to improve small bowel preparation for VCE.

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Rectal burn caused by hot-water coffee enema

Cited by 12 publications

References 0 publications

Pharmacokinetics of Caffeine following a Single Administration of Coffee Enema versus Oral Coffee Consumption in Healthy Male Subjects

Pharmacokinetics of Caffeine following a Single Administration of Coffee Enema versus Oral Coffee Consumption in Healthy Male Subjects

The safety and effectiveness of self-administered coffee enema

Coffee Enema for Preparation for Small Bowel Video Capsule Endoscopy: A Pilot Study

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