Rectal bleeding after hypofractionated radiotherapy for prostate cancer: Correlation between clinical and dosimetric parameters and the incidence of grade 2 or worse rectal bleeding

Akimoto, Tetsuo; Muramatsu, Hiroyuki; Takahashi, Mitsuhiro; Saito, Junichi; Kitamoto, Yoshizumi; Harashima, Koichi; Miyazawa, Yuri; Yamada, Masami; Ito, Kazuto; Kurokawa, K; Yamanaka, Hidetoshi; Nakano, Takashi; Mitsuhashi, Norio; Niibe, Hideo

doi:10.1016/j.ijrobp.2004.07.695

Cited by 95 publications

(54 citation statements)

References 26 publications

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“…p # 0.01(bold italics) p > 0.01, p < 0.05 (italics only) available published data (circa 2000) and are, therefore, most relevant to rectal bleeding. More recently, an understanding has emerged that volumes receiving lower doses might also contribute to the development of late effects (9,13,16,21,22). The recent Fiorino constraints are not just determined from rectal bleeding, for example, the constraint at 40 Gy is implicitly defined for rectal incontinence.…”

Section: Discussionmentioning

confidence: 99%

Dose–Volume Constraints to Reduce Rectal Side Effects From Prostate Radiotherapy: Evidence From MRC RT01 Trial ISRCTN 47772397

Gulliford

Foo

Morgan

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

127

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Section: Discussionmentioning

confidence: 99%

Dose–Volume Constraints to Reduce Rectal Side Effects From Prostate Radiotherapy: Evidence From MRC RT01 Trial ISRCTN 47772397

Gulliford

Foo

Morgan

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

127

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“…Dose-volume relationships for rectal toxicity are well known from the literature [1,2,4,6,9,12,23]. Studies examining these relationships usually compared patients that were treated with different total doses.…”

Section: Discussionmentioning

confidence: 99%

Impact of the Target Volume (Prostate Alone vs. Prostate with Seminal Vesicles) and Fraction Dose (1.8 Gy vs. 2.0 Gy) on Quality of Life Changes After External-Beam Radiotherapy for Prostate Cancer

et al. 2009

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“…Acute or chronic side effects can also be aggravated after a radiotherapy accident such as an overdose. The risk factors for complications are age, irradiated volume, histories of abdominal surgery, androgenic hardship, diabetes, hemorrhoids and inflammatory intestinal diseases [4] .…”

Section: Post-radiation Damagesmentioning

confidence: 99%

New insights for pelvic radiation disease treatment: Multipotent stromal cell is a promise mainstay treatment for the restoration of abdominopelvic severe chronic damages induced by radiotherapy

Chapel¹,

François²,

Douay³

et al. 2013

WJSC

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Radiotherapy may induce irreversible damage on healthy tissues surrounding the tumor. It has been reported that the majority of patients receiving pelvic radiation therapy show early or late tissue reactions of graded severity as radiotherapy affects not only the targeted tumor cells but also the surrounding healthy tissues. The late adverse effects of pelvic radiotherapy concern 5% to 10% of them, which could be life threatening. However, a clear medical consensus concerning the clinical management of such healthy tissue sequelae does not exist. Although no pharmacologic interventions have yet been proven to efficiently mitigate radiotherapy severe side effects, few preclinical researches show the potential of combined and sequential pharmacological treatments to prevent the onset of tissue damage. Our group has demonstrated in preclinical animal models that systemic mesenchymal stromal cell (MSC) injection is a promising approach for the medical management of gastrointestinal disorder after irradiation. We have shown that MSCs migrate to damaged tissues and restore gut functions after irradiation. We carefully studied side effects of stem cell injection for further application in patients. We have shown that clinical status of four patients suffering from severe pelvic side effects resulting from an over-dosage was improved following MSC injection in a compationnal situation.

show abstract

Rectal bleeding after hypofractionated radiotherapy for prostate cancer: Correlation between clinical and dosimetric parameters and the incidence of grade 2 or worse rectal bleeding

Cited by 95 publications

References 26 publications

Dose–Volume Constraints to Reduce Rectal Side Effects From Prostate Radiotherapy: Evidence From MRC RT01 Trial ISRCTN 47772397

Dose–Volume Constraints to Reduce Rectal Side Effects From Prostate Radiotherapy: Evidence From MRC RT01 Trial ISRCTN 47772397

Impact of the Target Volume (Prostate Alone vs. Prostate with Seminal Vesicles) and Fraction Dose (1.8 Gy vs. 2.0 Gy) on Quality of Life Changes After External-Beam Radiotherapy for Prostate Cancer

New insights for pelvic radiation disease treatment: Multipotent stromal cell is a promise mainstay treatment for the restoration of abdominopelvic severe chronic damages induced by radiotherapy

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