Recruitment of a Population‐Based Sample of Young Black Women with Breast Cancer through a State Cancer Registry

Bonner, Devon; Cragun, Deborah; Reynolds, Monique; Vadaparampil, Susan T.; Pal, Tuya

doi:10.1111/tbj.12545

Cited by 12 publications

(16 citation statements)

References 30 publications

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“…245–248 Lessons can also be learned from successful examples of recruiting other racial and ethnic minority patients who have survived breast cancer. 249 Elements that appear to bolster success include partnership with community-based organizations that provide services to Latinas and the provision of language-concurrent clinical care. 250–252 The heterogeneity of the US Latina population must also be considered, because different cultural influences, levels of awareness of, and interest in genetic and genomic services appear to vary by country of origin.…”

Section: Discussionmentioning

confidence: 99%

Genomic Disparities in Breast Cancer among Latinas

Lynce¹,

Graves

Jandorf

et al. 2016

Cancer Control

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Background Breast cancer is the most common cancer diagnosed among Latinas in the United States and the leading cause of cancer-related death among this population. Latinas tend to be diagnosed at a later stage and have worse prognostic features than their non-Hispanic white counterparts. Genetic and genomic factors may contribute to observed breast cancer health disparities in Latinas. Methods We provide a landscape of our current understanding and the existing gaps that need to be filled across the cancer prevention and control continuum. Results We summarize available data on mutations in high and moderate penetrance genes for inherited risk of breast cancer and the associated literature on disparities in awareness of and uptake of genetic counseling and testing in Latina populations. We also discuss common genetic polymorphisms and risk of breast cancer in Latinas. In the treatment setting, we examine tumor genomics and pharmacogenomics in Latina patients with breast cancer. Conclusions As the US population continues to diversify, extending genetic and genomic research into this underserved and understudied population is critical. By understanding the risk of breast cancer among ethnically diverse populations, we will be better positioned to make treatment advancements for earlier stages of cancer, identify more effective and ideally less toxic treatment regimens, and increase rates of survival.

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Section: Discussionmentioning

confidence: 99%

Genomic Disparities in Breast Cancer among Latinas

Lynce¹,

Graves

Jandorf

et al. 2016

Cancer Control

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“…Analyses comparing the parent study to the registry participant eligible sample to the presumed eligible individuals from the registry (n=1191) [9] as well as analyses comparing participants in the current study (n=355) to those who only participated in the parent study (n=89) indicate no differences in relationship status, insurance, mean age of diagnosis, stage at diagnosis, employment, or residence in a metropolitan area. A greater number of participants in the current study had known TNBC-status (p<0.0001) compared to those participating only in the parent study.…”

Section: Resultsmentioning

confidence: 99%

“…Second, participants were recruited from a single state; thus, findings may not be generalizable beyond Florida. However, our participants are representative of the larger state registry of BC patients [9] and received care in a variety of clinical and geographic locations enhancing study generalizability. Third, women with TNBC may be underrepresented in our study due to survival bias.…”

Section: Discussionmentioning

confidence: 99%

“…Recruitment methods and participation are detailed elsewhere and are briefly described here [9,10]. Eligible participants were self-identified Black women who were: living in Florida when diagnosed with invasive BC, at or below age 50 between 2009–2012, alive at time of recruitment, and English speaking.…”

Section: Methodsmentioning

confidence: 99%

“…Such information is a necessary first step in determining whether there is need for targeted interventions to improve BC survivorship for Black women. In the current study, we examined HRQOL in TNBC and non-TNBC patients participating in a larger population-based, case-only study investigating the etiology and outcomes of early-onset BC in Black women [7,8]. …”

Section: Introductionmentioning

confidence: 99%

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Health-related quality of life in Black breast cancer survivors with and without triple-negative breast cancer (TNBC)

Vadaparampil

Christie

Donovan

et al. 2017

Breast Cancer Res Treat

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Purpose Black women are more likely to develop early onset (≤50 years) breast cancer (BC) and have the lowest five-year, cause-specific survival rate of any United States (U.S.) racial or ethnic group. These disparities can be attributed partially to the higher rate of triple negative BC (TNBC) in Blacks. Yet, little is known about health-related quality of life (HRQOL) among Black women with TNBC. Methods Black women with invasive BC ≤50 years were recruited via the Florida State Cancer Registry as part of a population-based case-only study of etiology and outcomes of early-onset invasive BC. Of 460 consented participants, a subset of 355 self-reported sociodemographic, clinical, and psychosocial variables were collected. Descriptive analyses included participants with known TNBC (n=85) or non-TNBC (n=245) disease. Univariable and multivariable analyses were conducted to examine differences in factors associated with HRQOL. Results In unadjusted analyses, TNBC participants had significantly lower FACT-B total scores (90.1 ± 27.9) compared to non-TNBC (98.5 ± 27.6) participants (p<0.05). For the TNBC group, multivariable analyses indicated five individual-level and three systemic-level factors explain 80% of the response variation in HRQOL. For the non-TNBC group, seven individual-level factors and three systemic-level factors account for 76% of the variation in HRQOL scores. Conclusions Compared to Black women with non-TNBC, TNBC women have worse HRQOL. There are key individual and systemic-level factors that are unique to both groups. Findings can inform future HRQOL interventions to support young Black BC survivors.

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The big reveal: Family disclosure patterns of BRCA genetic test results among young Black women with invasive breast cancer

Conley

Ketcher

Reblin

et al. 2020

Journal of Genetic Counseling

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Despite higher incidence and mortality of breast cancer among younger Black women, genetic testing outcomes remain severely understudied among Blacks. Past research on disclosure of genetic testing results to family members has disproportionately focused on White, educated, high socioeconomic status women. This study addresses this gap in knowledge by assessing (a) to whom Black women disclose genetic test results and (b) if patterns of disclosure vary based on test result (e.g., BRCA1/2 positive, negative, variant of uncertain significance [VUS]). Black women (N = 149) with invasive breast cancer diagnosed age ≤50 years from 2009 to 2012 received free genetic testing through a prospective, population‐based study. At 12 months post‐testing, women reported with whom they shared their genetic test results. The exact test by binomial distribution was used to examine whether disclosure to female relatives was significantly greater than disclosure to male relatives, and logistic regression analyses tested for differences in disclosure to any female relative, any male relative, parents, siblings, children, and spouses by genetic test result. Most (77%) women disclosed their results to at least one family member. Disclosure to female relatives was significantly greater than disclosure to males (p < .001). Compared to those who tested negative or had a VUS, BRCA1/2‐positive women were significantly less likely to disclose results to their daughters (ORBRCA positive = 0.25, 95% CI = 0.07–0.94, p = .041) by 12 months post‐genetic testing. Genetic test result did not predict any other type of disclosure (all ps > 0.12). Results suggest that in Black families, one benefit of genetic testing—to inform patients and their family about cancer risk information—is not being realized. To increase breast cancer preventive care among high‐risk Black women, the oncology care team should prepare Black BRCA1/2‐positive women to share genetic test results with family members and, in particular, their daughters.

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Recruitment of a Population‐Based Sample of Young Black Women with Breast Cancer through a State Cancer Registry

Cited by 12 publications

References 30 publications

Genomic Disparities in Breast Cancer among Latinas

Genomic Disparities in Breast Cancer among Latinas

Health-related quality of life in Black breast cancer survivors with and without triple-negative breast cancer (TNBC)

The big reveal: Family disclosure patterns of BRCA genetic test results among young Black women with invasive breast cancer

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