2021
DOI: 10.1186/s13063-021-05346-x
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Recruitment and retention rates in randomised controlled trials of exercise therapy in people with multimorbidity: a systematic review and meta-analysis

Abstract: Aim To quantify recruitment, retention and differential retention rates and associated trial, participant and intervention characteristics in randomised controlled trials (RCTs) evaluating the effect of exercise therapy in people with multimorbidity. Data sources MEDLINE, EMBASE, CINAHL and CENTRAL from 1990 to April 20, 2020. Study selection RCTs including people with multimorbidity comparing exercise… Show more

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Cited by 21 publications
(13 citation statements)
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“…While we were unable to find any systematic reviews that screened for frailty and documented retention, our results are similar to other systematic reviews of retention in RCTs of PR in populations with chronic health conditions (e.g. 82.8% for adults with major depressive disorder [ 54 ], 93% for adults with cancer, cardiovascular disease or diabetes [ 55 ]) and 90% in people with multimorbidity [ 56 ]. In contrast, systematic reviews of PR interventions in adults with human immunodeficiency viruses ( n = 36 RCTs, 71%) [ 57 ] and schizophrenia ( n = 19 RCTs, 73%) [ 58 ] documented lower retention rates.…”
Section: Discussionsupporting
confidence: 65%
“…While we were unable to find any systematic reviews that screened for frailty and documented retention, our results are similar to other systematic reviews of retention in RCTs of PR in populations with chronic health conditions (e.g. 82.8% for adults with major depressive disorder [ 54 ], 93% for adults with cancer, cardiovascular disease or diabetes [ 55 ]) and 90% in people with multimorbidity [ 56 ]. In contrast, systematic reviews of PR interventions in adults with human immunodeficiency viruses ( n = 36 RCTs, 71%) [ 57 ] and schizophrenia ( n = 19 RCTs, 73%) [ 58 ] documented lower retention rates.…”
Section: Discussionsupporting
confidence: 65%
“…Overall, we performed one scoping review [35], five systematic reviews [27,[36][37][38][39][40], two registry-based studies [41,42], one qualitative interview study [43], and a mixed-methods feasibility study [34], to identify knowledge gaps and develop an exercise therapy and self-management intervention for people with multimorbidity (Table 1) and Fig. 1.…”
Section: Resultsmentioning
confidence: 99%
“…These conditions are linked by a common risk factor (physical inactivity) and pathogenesis (systemic low-grade inflammation), resulting in a cascade of reactions resulting in a 'vicious cycle' of chronic diseases and poor outcomes [44,45]. For two systematic reviews, we included studies reporting at least 80% of the patients with multimorbidity (as defined above) [27,40]. This pragmatic approach was pre-specified [37], and adopted to capture all the studies which included people with multimorbidity, given the expected inconsistency of reporting of the conditions across trials.…”
Section: Populationmentioning
confidence: 99%
“…Our results are reasonably aligned with results from a systematic review published in 2021, where the authors investigated recruitment and retention rates in exercise RCTs for people with multimorbidity. 49 They reported an average recruitment rate of 75% and a retention rate of 90% however, the included studies were deemed to be of low quality and therefore results must be interpreted with caution.…”
Section: Discussionmentioning
confidence: 99%