Recruitment and Retention of Women Living With HIV for Clinical Research: A Review

Mendez, Kyra Jennifer Waligora; Cudjoe, Joycelyn; Strohmayer, Sarah; Han, Hae Ra

doi:10.1007/s10461-021-03273-1

Cited by 10 publications

(19 citation statements)

References 40 publications

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“…The Johns Hopkins Medicine institutional Review Board approved all study procedures. Study participants were recruited using community-based methods, which are published elsewhere ( Mendez et al, 2021 ). In short, women were referred by community organizations, local HIV health clinics, and an HIV/AIDS research center affiliated with a university ( Mendez et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

“…Study participants were recruited using community-based methods, which are published elsewhere ( Mendez et al, 2021 ). In short, women were referred by community organizations, local HIV health clinics, and an HIV/AIDS research center affiliated with a university ( Mendez et al, 2021 ). Trained research staff screened women over the phone for eligibility.…”

Section: Methodsmentioning

confidence: 99%

“…Likewise, we used a convenience sample of 123 WLH in Baltimore, Maryland, which may limit the generalizability of study findings to inner city WLH. Nevertheless, our study offers novel insights on inner city, Black WLH, who are underresearched ( Mendez et al, 2021 ).…”

Section: Limitationsmentioning

confidence: 99%

See 2 more Smart Citations

A Descriptive Analysis of Cancer Screening Health Literacy Among Black Women Living with HIV in Baltimore, Maryland

Sun¹,

Chepkorir²,

Mendez³

et al. 2022

HLRP: Health Literacy Research and Practice

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Background: Black women living with HIV (WLH) have the highest HIV infection rate, cervical cancer mortality, and the lowest cancer screening use compared to other groups. However, there is a gap in knowledge about cancer screening health literacy in the Black WLH population. Objective: The purpose of this study was to assess the level of cancer screening health literacy, and to identify factors associated with health literacy among Black WLH. Methods: This study used baseline data from a community-based randomized controlled trial for a health literacy intervention called CHECC-uP (community-based health literacy intervention for cancer control). We recruited a convenience sample of Black WLH ( N = 123) who understand English and had no Pap testing in the prior 12 months. The outcome was cancer screening health literacy measured with a validated health literacy tool—Assessment of Health Literacy in Cancer Screening. Predictors included age, marital status, education, income, and insurance type. The association between cancer screening health literacy and predictors was assessed with multivariate logistic regression. Key Results: Almost one-half (49.6%) of study participants had a reading level at or below sixth grade. Older age (adjusted odds ratio [aOR] 1.05) and higher educational levels (aOR 5.13) were significantly associated with higher cancer screening health literacy among our sample of Black WLH in bivariate and multivariate analyses. Conclusions: Educational materials and other approaches to empower patients should be tested with patients who have low health literacy to ensure efficacy. [ HLRP: Health Literacy Research and Practice . 2022;6(3):e175–e181. ] Plain Language Summary: Using a cancer screening health literacy tool, we found that about one-half of the Black WLH in the study had a reading level at or below sixth grade. Age and education level were related to their reading levels among the women. Researcher and clinicians need to test educational materials and other approaches with patients who have low health literacy to make sure they work.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A Descriptive Analysis of Cancer Screening Health Literacy Among Black Women Living with HIV in Baltimore, Maryland

Sun¹,

Chepkorir²,

Mendez³

et al. 2022

HLRP: Health Literacy Research and Practice

Self Cite

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“…Despite considerable barriers to research for women, there are many interventions 26 which may address these. A survey 27 carried out of women living with HIV in Canada in 2014 found that it was important that research personnel were respectful, skilled, flexible, and empathic with good communication skills.…”

Section: Background – the Perspective Of Consultants In Sexual Health And Hiv Medicinementioning

confidence: 99%

From presumptive exclusion towards fair inclusion: perspectives on the involvement of women living with HIV in clinical trials, including stakeholders’ views

Namiba

Kwardem

Dhairyawan

et al. 2022

Therapeutic Advances in Infection

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2journals.sagepub.com/home/tai black women were under-recruited by around 35%. They also found that despite most of the global burden of HIV being in low and low-middle-income countries, most of the trials were carried out in high and high-middle-income countries. A systematicreview 5 of HIV cure research published in 2015 found that women, as well as older people and those of non-white ethnicities were profoundly under-represented.This pattern of under-recruitment is not only seen in HIV, but in many disease areas including cardiovascular disease, 7 cancer, 8 and mental health conditions. 9 Sex and gender differences 10 in the prevalence,incidence, 11 symptomatology, andprogression 12 of a range of diseases have been described, as have differences in responses to treatment. These differences in treatment responses are likely to be attributable to differences in how the body deals with a drug (pharmacokinetics) and the effect of the drug on the body (pharmacodynamics). This may affect the efficacy and tolerability of thedrug. 13 Importantly, sex 14 and gender 15 inequalities 16 in social and economic power also have a large impact on health outcomes, affecting health-seeking behaviour, access to, and utilisation of healthcare services.journals.sagepub.com/home/tai 13Visit SAGE journals online journals.sagepub.com/ home/tai

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“…Women living with HIV are underrepresented in clinical research, counting only 21% to 39% of the total investigated population. 1 Physiological changes occurring during pregnancy affect the pharmacokinetics (PK) of drugs. The drug's disposition is influenced by the dynamic interactions between drug-metabolizing enzymes and membraneassociated drug transporters belonging to the adenosine triphosphate-binding cassette and the solute carrier transporter superfamilies.…”

mentioning

confidence: 99%

P‐Glycoprotein and Organic Anion Transporter Polypeptide 1B/Breast Cancer Resistance Protein Drug Transporter Activity in Pregnant Women Living With HIV

Moreira

Melli

Marques

et al. 2022

The Journal of Clinical Pharma

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This study evaluates the influence of pregnancy and HIV infection in conjunction with the use of raltegravir,lamivudine,and tenofovir disoproxil fumarate (combined antiretroviral therapy [cART]) on intestinal P-glycoprotein (P-gp) and hepatic organic anion transporter polypeptide (OATP) 1B1/1B3 and/or breast cancer resistance protein (BCRP) drug transporter activity using rosuvastatin (OATP1B/BCRP) and fexofenadine (P-gp) probes. Single oral doses of 5-mg rosuvastatin and 60-mg fexofenadine were administered to women living with HIV under cART in the third trimester of gestation (n = 15) and postpartum period (n = 10). A control group of 12 healthy nonpregnant women also was investigated. Pharmacokinetic parameters were estimated by using a noncompartmental method and evaluated by t test (P < .05). The rosuvastatin area under the plasma concentration-time curve from time 0 to the last quantifiable concentration (AUC 0-last ) value was higher in the third trimester of pregnancy (19.5 [95%CI,] ng • h/mL] when compared to postpartum (13.3 [95%CI,] ng • h/mL), while the fexofenadine AUC 0-last values did not differ between the third trimester of pregnancy (738.0 [95%CI,] ng • h/mL) and postpartum period (874.9 [95%CI, 408.2-1342.0] ng• h/mL). The rosuvastatin AUC 0-last values did not differ between healthy nonpregnant women (13.8 [95%CI,] ng • h/mL) and women living with HIV in the postpartum period (13.3 [95%CI,] ng • h/mL), and the fexofenadine AUC 0-last values did not differ between the 2 investigated groups (603.6 [95%CI,] ng • h/mL vs 874.9 [95%CI, 408.2-1342.0] ng • h/mL). It is suggested that gestation inhibits the hepatic OATP1B1/1B3 and/or BCRP activity but does not alter intestinal P-gp activity. The influence of HIV infection in conjunction with use of cART on OATP1B/BCRP and intestinal P-gp activity was not observed.

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Recruitment and Retention of Women Living With HIV for Clinical Research: A Review

Cited by 10 publications

References 40 publications

A Descriptive Analysis of Cancer Screening Health Literacy Among Black Women Living with HIV in Baltimore, Maryland

A Descriptive Analysis of Cancer Screening Health Literacy Among Black Women Living with HIV in Baltimore, Maryland

From presumptive exclusion towards fair inclusion: perspectives on the involvement of women living with HIV in clinical trials, including stakeholders’ views

P‐Glycoprotein and Organic Anion Transporter Polypeptide 1B/Breast Cancer Resistance Protein Drug Transporter Activity in Pregnant Women Living With HIV

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