Recruitment and maturation of the coronary collateral circulation: Current understanding and perspectives in arteriogenesis

Allahwala, U.; Khachigian, Levon M.; Nour, Daniel; Ridiandres, Anisyah; Billah, Muntasir; Ward, Michael R.; Weaver, James; Bhindi, Ravinay

doi:10.1016/j.mvr.2020.104058

Cited by 29 publications

(24 citation statements)

References 169 publications

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“…Chronic coronary total occlusions (CTOs) are defined as 100% occlusions with Thrombolysis in Myocardial Infarction (TIMI) 0 flow and at least a 3-month duration (1). Coronary collateralization (CC) is a process that utilizes a network of arterial-arterial anastomotic connections present in the heart between vascular branches from different regions to provide an alternative source of blood supply to the myocardium jeopardized by ischemia (2)(3)(4). Good CC contributes to a reduction in infarct size, relieves angina, protects cardiac function, and reduces mortality risk (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Association of Visceral Obesity-Related Indices With Coronary Collateralization in Patients With Chronic Total Occlusion

Shao

Luo

Shi

et al. 2021

Front. Cardiovasc. Med.

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Background: Obesity is an independent risk factor for cardiovascular disease. We investigated whether and to what extent visceral obesity-related indices were associated with coronary collateralization (CC) in chronic total occlusion (CTO) patients.Methods: This retrospective cohort study involved 1,008 consecutive patients with CTO who underwent CTO-percutaneous coronary artery intervention (PCI). CC was graded according to the Rentrop scoring system. Data on demographic and clinical characteristics were collected by cardiovascular doctors. Logistic regression, receiver operating characteristic (ROC) curve and Kaplan-Meier analyses were performed to assess the predictive value of visceral obesity-related indices for CC.Results: Overall, 1,008 inpatients were assigned to the poor CC group (n = 592) and good CC group (n = 416). In multivariate-adjusted logistic regression analyses, all visceral obesity-related indices (P-value < 0.001) were significantly associated with CC. After ROC analysis and the Delong test, the Chinese visceral adiposity index (CVAI) had the largest area under the curve (AUC) of 0.741 (0.711–0.771). Further analysis revealed that CVAI quartile remained a risk factor for poor CC in all groups, CVAI was associated with a 1.018-fold higher risk of poor CC (OR = 1.018, 95% CI: 1.014–1.021, P < 0.001). Individuals in the top CVAI quartile group had the highest risk of poor CC (OR = 10.657, 95% CI: 6.492–17.493, P < 0.001). Subgroup analyses showed similar results, and CVAI quartile remained a risk factor for poor CC. Moreover, increased CVAI predicted poor prognosis in CTO patients.Conclusion: In summary, this study indicated that all the increased visceral obesity-related indices were significantly associated with increased poor CC risk. After adjusting for potential risks, CVAI had the best performance for estimating CC and predicting prognosis in CTO patients.

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Section: Introductionmentioning

confidence: 99%

Association of Visceral Obesity-Related Indices With Coronary Collateralization in Patients With Chronic Total Occlusion

Shao

Luo

Shi

et al. 2021

Front. Cardiovasc. Med.

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“…There is a reduction in the accumulation of MNCs followed by abnormal flow restoration in MCP-1 deficient mice [ 36 ] . After recruitment, monocytes secrete fibroblast growth factor (FGF), the main driver of arteriogenesis [ 37 ] . Yu et al found that the promotion of arteriogenesis in the ischemic myocardium is associated with the increase of FGF [ 38 ] .…”

Section: Discussionmentioning

confidence: 99%

Isometric exercise promotes arteriogenesis in rats after myocardial infarction

et al. 2021

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Isometric exercise (IE) is a promising intervention of noninvasive revascularization in patients with acute myocardial infarction (AMI). This study aimed to investigate the impact and mechanisms of IE training on arteriogenesis in AMI. Male Sprague-Dawley rats were randomly assigned into the sham-operation group (SO), myocardial infarction (MI) group, and 13 IE subgroups treated according to training intensity, frequency, duration, or monocyte chemoattractant protein-1 (MCP-1), or/and fibroblast growth factor-2 (FGF-2) inhibitors for eight weeks. Our results demonstrated that the IE group achieved superior improvement compared with the MI group in terms of left ventricular ejection fraction (LVEF), myocardial infarction size (MIS), arterial density (AD), monocytes (MNCs), smooth muscle cells (SMCs), endothelial cells (ECs), relative collateral blood flow (RCBF), MCP-1, and FGF-2 at the endpoint. Positive correlations between MCP-1 and MNCs, MNCs and FGF-2, FGF-2 and SMCs, SMCs and AD, as well as AD and RCBF were observed. This study demonstrated that with MI of 100% load 20 times daily for eight weeks, the arteriogenesis was improved, which may be attributed to the recruitment of MNCs and SMCs in remote ischemic myocardium caused by increases in MCP-1 and FGF-2 expression.

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“…Next, in ammatory cytokines adhere to the endothelium and differentiate into macrophages, which paly an important role in vessel growth and development. Finally, collateral vessels increase diameter because of muscle cells proliferate and switch to a contractile phenotype [5].…”

Section: The Mechanisms Of Mets Reduce Coronary Collateralizationmentioning

confidence: 99%

“…Vasculogenesis, angiogenesis and arteriogenesis are three important processes for the formation of CCs, which in uenced by signalling and transcriptional control, soluble mediators and their receptors, biomechanical forces and hypoxia. Abdominal obesity and dyslipidemia indicate the vascular endothelial dysfunction, which impair the processes of CCs [5]. Shen Y et al revealed that the type 2 diabetes mellitus (T2DM) adversely affected coronary collateral development through multiple cellular mechanisms [6].…”

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confidence: 99%

Metabolic Syndrome and Its Components Reduce Coronary Collateralization in Chronic Total Occlusion: an Observational Study

Liu

et al. 2021

Preprint

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Background: Metabolic syndrome (METs) is an independent risks for the incidence of cardiovascular diseases. We investigated whether or to what extent the METs and its components was associated with coronary collateralization (CC) in chronic total occlusion (CTO).Methods: This study involved 1709 inpatients with CTO. Data on demographic and clinical characteristics were collected by cardiovascular doctors. The CC condition was defined by Rentrop score system. Subgroup analysis, mixed models regression analysis, score systems and receiver-operating characteristic curves (ROC) analysis were done. Results: Overall, 1709 inpatients were assigned to the Poor CC group (n = 370), good CC group (n = 1339) with or without METs. Compared to good CC, the incidence of METs was higher in poor CC for overall patients. Poor collateralization was present in 9.1%, 14.4%, 19.9%, 18.1%, 35.1% and 54.2% of the six groups, who met the diagnostic criteria of MetS 0, 1, 2, 3, 4 and 5 times. For multivariable logistic regression, quartiles of BMI remained the risk factors of CC growth in all subgroups (adjusted OR = 1.728, 95% CI 1.518-1.967, P < 0.001 all patient group , adjusted OR = 1.827, 95% CI 1.484-2.249, P < 0.001 No-METs group and adjusted OR = 1.771, 95% CI 1.484-2.115,P < 0.001 METs group). After adjustment for potential confounding factors, METs was an independent risk factors of CC growth in several models. Assigning a score of one for each components, this score system had significant predictive value for the CC conditions by Receiver-operating characteristic(AUC: 0.622, 95%CI: 0.588-0.655) .Conclusions: METs, especially for body mass index, confers greater risk for CC formation in CTO. Score systems may help to predict CC condition.

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Recruitment and maturation of the coronary collateral circulation: Current understanding and perspectives in arteriogenesis

Cited by 29 publications

References 169 publications

Association of Visceral Obesity-Related Indices With Coronary Collateralization in Patients With Chronic Total Occlusion

Association of Visceral Obesity-Related Indices With Coronary Collateralization in Patients With Chronic Total Occlusion

Isometric exercise promotes arteriogenesis in rats after myocardial infarction

Metabolic Syndrome and Its Components Reduce Coronary Collateralization in Chronic Total Occlusion: an Observational Study

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