Recruitment and disruption of value encoding during alcohol seeking

Ottenheimer, David J.; Wang, Karen; Haimbaugh, Alex; Janak, Patricia H.; Jm, Richard

doi:10.1101/513911

Cited by 1 publication

(3 citation statements)

References 55 publications

(65 reference statements)

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“…These findings are corroborated by the observation that pharmacological or optogenetic inhibition of VP neurons disrupts reward processing and leads to increased task errors and longer latencies to reward consumption. Interestingly, the encoding of incentive value by VP neurons is generally faster and more accurate than that of "upstream" ventral striatal neurons (Ambroggi et al, 2011;Richard et al, 2016;Fujimoto et al, 2019;Ottenheimer et al, 2019), which suggests a more central role of the VP in reward processing than previously thought.…”

Section: Reinforcement Learning Reward Processing and Salience Attrib...mentioning

confidence: 72%

“…VP neurons show heterogeneous activity during cocaine and alcohol seeking (Root et al, 2010;Ottenheimer et al, 2019), that differs based on their anatomical location (Root et al, 2012(Root et al, , 2013. Overall, neurons in the dlVP are more active than those in the vmVP when rats approach an operandum to self-administer cocaine (Root et al, 2012).…”

Section: Hedonic Processing and Food Consumptionmentioning

confidence: 99%

“…Furthermore, alcohol pre-exposure disrupts VP reward processing for sucrose, and results in augmented responses to instrumental stimuli and diminished responses to Pavlovian sucroseconditioned stimuli. This may be explained by reward-seeking becoming more habitual and less dependent on outcomes after exposure to alcohol (Ottenheimer et al, 2019). In addition, VP reward processing is disrupted by repeated systemic administrations of amphetamine, or a single intra-accumbens administration of this drug.…”

Section: Hedonic Processing and Food Consumptionmentioning

confidence: 99%

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Ventral pallidal regulation of motivated behaviors and reinforcement

Soares‐Cunha

Heinsbroek

2023

Front. Neural Circuits

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The interconnected nuclei of the ventral basal ganglia have long been identified as key regulators of motivated behavior, and dysfunction of this circuit is strongly implicated in mood and substance use disorders. The ventral pallidum (VP) is a central node of the ventral basal ganglia, and recent studies have revealed complex VP cellular heterogeneity and cell- and circuit-specific regulation of reward, aversion, motivation, and drug-seeking behaviors. Although the VP is canonically considered a relay and output structure for this circuit, emerging data indicate that the VP is a central hub in an extensive network for reward processing and the regulation of motivation that extends beyond classically defined basal ganglia borders. VP neurons respond temporally faster and show more advanced reward coding and prediction error processing than neurons in the upstream nucleus accumbens, and regulate the activity of the ventral mesencephalon dopamine system. This review will summarize recent findings in the literature and provide an update on the complex cellular heterogeneity and cell- and circuit-specific regulation of motivated behaviors and reinforcement by the VP with a specific focus on mood and substance use disorders. In addition, we will discuss mechanisms by which stress and drug exposure alter the functioning of the VP and produce susceptibility to neuropsychiatric disorders. Lastly, we will outline unanswered questions and identify future directions for studies necessary to further clarify the central role of VP neurons in the regulation of motivated behaviors.Significance: Research in the last decade has revealed a complex cell- and circuit-specific role for the VP in reward processing and the regulation of motivated behaviors. Novel insights obtained using cell- and circuit-specific interrogation strategies have led to a major shift in our understanding of this region. Here, we provide a comprehensive review of the VP in which we integrate novel findings with the existing literature and highlight the emerging role of the VP as a linchpin of the neural systems that regulate motivation, reward, and aversion. In addition, we discuss the dysfunction of the VP in animal models of neuropsychiatric disorders.

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Section: Reinforcement Learning Reward Processing and Salience Attrib...mentioning

confidence: 72%