Recrudescent Plasmodium falciparum infections in children in an endemic area following artemisinin–based combination treatments: Implications for disease control

Gbotosho, Grace O.; Dokunmu, Titilope M.; Happi, Christian; Sowunmi, A.

doi:10.1016/s2222-1808(11)60027-3

Cited by 15 publications

(5 citation statements)

References 37 publications

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“…The observed antiplasmodial activity may be related to the presence of terpenes, steroids, coumarins, flavonoids, phenolica acids, lignans, xanthones and anthraquonones [57] . Antibacterial activity of silver nanoparticles was exhibited by using stem derived callus extract of bitter apple Citrullus colocynthis [58][59][60][61] . The antiparasitic activity was shown by the aqueous crude leaf extracts and synthesized silver nanoparticles of Mimosa pudica [62] .…”

Section: Discussionmentioning

confidence: 99%

Synthesis of silver nanoparticles using leaves of Catharanthus roseus Linn. G. Don and their antiplasmodial activities

Sekar

Panneerselvam

Murugan

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

395

159

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Section: Discussionmentioning

confidence: 99%

Synthesis of silver nanoparticles using leaves of Catharanthus roseus Linn. G. Don and their antiplasmodial activities

Sekar

Panneerselvam

Murugan

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

395

159

View full text Add to dashboard Cite

“…In summary, although existing gold lateral flow strips are robust, simple and good for positive or negative determination, use of fluorescence offers the advantages of quantitation and increased sensitivity when these requirements are needed. Examples of where these requirements may offer significant advantage include accurate quantitation of cardiac markers [ 18 ]; quantitation and identification of environmental contaminants [ 19 ]; detection of low parasite levels prior to malaria recrudescence [ 20 ]; and quantitation of tumor markers such as prostate specific antigen and CA-125 [ 21 ]. We have demonstrated a route to offer these advantages in a point-of-use setting.…”

Section: Discussionmentioning

confidence: 99%

A Low-Cost, High-Performance System for Fluorescence Lateral Flow Assays

Lee¹,

Nordman²,

Johnson³

et al. 2013

Biosensors

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We demonstrate a fluorescence lateral flow system that has excellent sensitivity and wide dynamic range. The illumination system utilizes an LED, plastic lenses and plastic and colored glass filters for the excitation and emission light. Images are collected on an iPhone 4. Several fluorescent dyes with long Stokes shifts were evaluated for their signal and nonspecific binding in lateral flow. A wide range of values for the ratio of signal to nonspecific binding was found, from 50 for R-phycoerythrin (R-PE) to 0.15 for Brilliant Violet 605. The long Stokes shift of R-PE allowed the use of inexpensive plastic filters rather than costly interference filters to block the LED light. Fluorescence detection with R-PE and absorbance detection with colloidal gold were directly compared in lateral flow using biotinylated bovine serum albumen (BSA) as the analyte. Fluorescence provided linear data over a range of 0.4–4,000 ng/mL with a 1,000-fold signal change while colloidal gold provided non-linear data over a range of 16–4,000 ng/mL with a 10-fold signal change. A comparison using human chorionic gonadotropin (hCG) as the analyte showed a similar advantage in the fluorescent system. We believe our inexpensive yet high-performance platform will be useful for providing quantitative and sensitive detection in a point-of-care setting.

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“…Our analyses do not focus on only the 84 days period but also on the first 42 days. Gbotosho [18] defined recrudescence as the reappearance of parasitaemia before day 42 and confirmed by polymerase chain reaction (PCR). After some time, reinfection cases start appearing but it is not clear when recrudescence no longer can appear.…”

Section: Introductionmentioning

confidence: 99%

A Nonparametric Bayesian Approach to Estimating Malaria Prophylactic Effect After Two Treatments

Kum¹,

Thorburn²,

Ghilagaber³

et al. 2013

ijsmr

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Two treatment regimens for malaria are compared in their abilities to cure and combat reinfection. Bayesian analysis techniques are used to compare two typical treatment therapies for uncomplicated malaria in children under five years, not only in their power to resist recrudescence, but also how long they can postpone recrudescence or reinfection in case of failure. We present a new way of analysing this type of data using Markov Chain Monte Carlo techniques. This is done using data from clinical trials at two different centres. The results which give the full posterior distributions show that artemisinin-based combination therapy is more efficacious than sulfadoxine-pyrimethamine. It both reduced the risk of recrudescence and delayed the time until recrudescence.

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Recrudescent Plasmodium falciparum infections in children in an endemic area following artemisinin–based combination treatments: Implications for disease control

Cited by 15 publications

References 37 publications

Synthesis of silver nanoparticles using leaves of Catharanthus roseus Linn. G. Don and their antiplasmodial activities

Synthesis of silver nanoparticles using leaves of Catharanthus roseus Linn. G. Don and their antiplasmodial activities

A Low-Cost, High-Performance System for Fluorescence Lateral Flow Assays

A Nonparametric Bayesian Approach to Estimating Malaria Prophylactic Effect After Two Treatments

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