Recovery Time After Sugammadex Reversal of Rocuronium-Induced Muscle Relaxation for Electroconvulsive Therapy Is Independent of Cardiac Output in Both Young and Elderly Patients

Kikuchi, Yuji; Nishida, Akiko; Saito, Shigeru

doi:10.1097/yct.0b013e31826cf348

Cited by 12 publications

(3 citation statements)

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“…The body of evidence enrolling adults included 191 studies (133 randomized controlled trials, 4,59–90,92,95,98–104,110–114,118–127,132–141,145–148,155–157,163,173–181,206–254 11 nonrandomized trials, 17,128,142,182–184,191,255–258 45 cohort studies, 15,42,86,91,93,94,96,97,105–109,116,117,129–131,143,144,186–190,227,259–277 and 2 before–after designs 115,168 ) evaluating efficacy and safety of antagonist drugs for neuromuscular blockade. The randomized controlled trials enrolling only adults had a median of 88 participants (range, 16 to 350).…”

Section: Antagonism Of Neuromuscular Blockadementioning

confidence: 99%

2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade

Thilen¹,

Weigel²,

Todd³

et al. 2023

Anesthesiology

118

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Section: Antagonism Of Neuromuscular Blockadementioning

confidence: 99%

2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade

Thilen¹,

Weigel²,

Todd³

et al. 2023

Anesthesiology

118

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“…In any case, what seems to be more relevant to the day-to-day practice of anesthesia is that the study conducted under usual anesthetic conditions did show a relationship between CO and sugammadex recovery time. (53) Based on that result, the onset time of sugammadex should be shortened by increasing the CO after increasing the pCO2 with any of the above mentioned methods.…”

Section: Influence Of Cardiac Output On the Emergence Phasementioning

confidence: 98%

Cardiac output and the pharmacology of general anesthetics: a narrative review

Simón-Polo,

Catalá-Ripoll,

Monsalve-Naharro

et al. 2023

Colomb. J. Anesthesiol.

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The relationship between cardiac output and anesthetic drugs is important to anesthesiologists, since cardiac output determines the speed with which a drug infused into the bloodstream reaches its target and the intensity of the drug’s effect. But rather than focus on how anesthetic drugs affect cardiac output, this narrative review focuses on how changes in cardiac output affect the pharmacokinetics and pharmacodynamics of general anesthetics during the three phases of anesthesia. At induction, an increase in cardiac output shortens both the onset time of propofol for hypnosis and the neuromuscular blocking effect of rapid-acting neuromuscular blockers, favoring the conditions for rapid sequence intubation. During maintenance, changes in cardiac output are followed by opposite changes in the drug plasma concentration of anesthetic drugs. Thus, an increase in cardiac output followed by a decrease in the plasma concentration of the anesthetic could expose the patient to a real risk of intraoperative awakening, which can be avoided by increasing the dose of hypnotic drugs. At emergence, an increase in cardiac output secondary to an increase in pCO2 allows for a more rapid recovery from anesthesia. The pCO2 can be increased by adding CO2 to the respiratory circuit, lowering the ventilatory rate, or placing the patient on partial rebreathing. Finally, the reversal action of sugammadex for rocuronium-induced neuromuscular block can be shortened by increasing the cardiac output.

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“…The muscle relaxant used is succinylcholine, which is a depolarizing muscle relaxant. Although non-depolarizing muscle relaxants may also be used to reduce myalgia and increased intragastric pressure, their long duration of action may lead to problems such as the need for a muscle relaxant antagonist [6] after ECT and residual muscle relaxation. Anesthesiologists are also aware that hyperventilation can lead to seizures.…”

Section: Drugs Commonly Used In Ectmentioning

confidence: 99%

Ketamine Anesthesia in Electroconvulsive Therapy

Satomoto¹

2022

Ketamine Revisited - New Insights Into NMDA Inhibitors

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Electroconvulsive therapy (ECT) is highly effective both Major Depressive Disorder (MDD) and Bipolar Disorder (BD). Ketamine, an antagonist of the N-Methyl-D-aspartate receptor, has been described to have antidepressant properties. There is a hypothesis that ECT performed with anesthesia using ketamine is more effective than conventional ECT. Also, although ECT is the gold standard for BD and MDD, there are questions about which is more effective, ketamine treatment or ECT, and whether ketamine is more effective when used in combination with ECT. In this chapter, we review the current literature on the effectiveness of ECT and ketamine. Furthermore, we discuss whether ketamine can be an alternative treatment to ECT for patients with TRD.

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Recovery Time After Sugammadex Reversal of Rocuronium-Induced Muscle Relaxation for Electroconvulsive Therapy Is Independent of Cardiac Output in Both Young and Elderly Patients

Cited by 12 publications

References 0 publications

2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade

2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade

Cardiac output and the pharmacology of general anesthetics: a narrative review

Ketamine Anesthesia in Electroconvulsive Therapy

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