Recovery Rates of Non-Tuberculous Mycobacteria from Clinical Specimens Are Increasing in Korean Tertiary-Care Hospitals

Kim, Namhee; Yi, Jongyoun; Chang, Chulhun L.

doi:10.3346/jkms.2017.32.8.1263

Cited by 25 publications

(24 citation statements)

References 19 publications

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“…The epidemiology of NTM pulmonary disease or infections has remained largely unclear in Korea. However, recent NTM epidemiology studies have shown that NTM pulmonary disease or infections are increasing steadily [17, 21, 22]. One study conducted in two Korean tertiary-care hospitals reported that the incidence of NTM pulmonary disease increased from 6.8 per 100,000 patients in 2009 to 12.9 per 100,000 patients in 2015 [21].…”

Section: Discussionmentioning

confidence: 99%

Prevalence, incidence, and mortality of nontuberculous mycobacterial infection in Korea: a nationwide population-based study

et al. 2019

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Background Epidemiologic characteristics of nontuberculous mycobacterial (NTM) disease remain largely unknown. The objective of this study was to evaluate incidence, prevalence, and mortality of NTM infection in a large nationwide population-based cohort in Korea. Methods Data of the National Health Insurance Service database, an extensive health-related database including most Korean residents, were used. Adults with a primary diagnosis of NTM as determined by International Classification of Disease-Tenth Revision coding (A31) were identified between 2003 and 2016. Incidence, prevalence, and mortality of NTM infection were analyzed. Results A total of 46,194 individuals had a primary diagnosis of NTM infection. Their mean age was 55.8 years. Of these subjects, 61.1% were females. Annual age-adjusted incidence and prevalence of NTM infection tended to increase rapidly from 2003 to 2016. Age-adjusted incidence and prevalence was 17.9 and 33.3 per 100,000 population in 2016. The incidence and prevalence were higher in females and the elderly. The 5-year mortality rate in the population with NTM infection was 17.8%. The standardized mortality ratio of patients with NTM infection to the general population was 2.16 (95% confidence interval: 2.10 to 2.22). Conclusions This large population-based study showed that the incidence and prevalence of NTM infection in Korea increased rapidly from 2003 to 2016. They were higher in women and the elderly. The mortality rate in the population with NTM infection was higher than that in the general population.

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Section: Discussionmentioning

confidence: 99%

Prevalence, incidence, and mortality of nontuberculous mycobacterial infection in Korea: a nationwide population-based study

et al. 2019

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“…Several studies have reported the increasing number of annual NTM isolates and the significant clinical relevance [20–22]. In Korea, the incidence of pulmonary NTM disease has doubled in 2015 compared to the number in 2009 [23, 24]. Japan revealed that NTM disease has reached 14.7 cases per 100, 000 people-years [25] .…”

Section: Introductionmentioning

confidence: 99%

Clinical and microbiological characteristics of non-tuberculous mycobacteria diseases in Singapore with a focus on pulmonary disease, 2012-2016

et al. 2019

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Background Information on non-tuberculosis mycobacterial (NTM) diseases remains limited in Singapore and other Southeast Asian countries. This study aimed to delineate epidemiological and clinical features of pulmonary NTM disease. Methods A retrospective review was performed on all NTM isolates identified in Singapore General Hospital from 2012 to 2016 using the 2007 ATS/IDSA diagnostic criteria. Results A total of 2026 NTM isolates from 852 patients were identified. M. abscessus-chelonae group (1010, 49.9%) was the most commonly isolated and implicated in pulmonary NTM disease. Pulmonary cases (352, 76%) had the highest prevalence among patients diagnosed with NTM diseases (465/852, 54.6%) with no gender difference. Male patients were older (68.5 years, P = 0.014) with a higher incidence of chronic obstructive pulmonary disease (COPD) (23.6%, P < 0.001) and recurrent cough with phlegm production (51.6%, P = 0.035). In contrast, more female patients had bronchiectasis (50%, P < 0.001) and haemoptysis (37.6%, P = 0.042). Age and COPD were associated with multiple NTM species isolation per patient. Conclusions M. abscessus-chelonae group was the commonest NTM species isolated in Singapore. Pulmonary NTM infection has the highest frequency with male and female patients associated with a higher incidence of COPD and bronchiectasis respectively. Age and COPD were associated with multiple NTM species isolation per patient.

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“… 6 In Korea, previous studies showed that the NTM isolation rate and the number of patients with NTM-LD have increased steadily. 7 8 9 10 11 12 However, the long-term trend of the changes of causative organisms of NTM-LD was not available in Korea.…”

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confidence: 99%

Changing Epidemiology of Nontuberculous Mycobacterial Lung Diseases in a Tertiary Referral Hospital in Korea between 2001 and 2015

Moon

Ahn

et al. 2018

J Korean Med Sci

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This study investigated the changes in the major etiologic organisms and clinical phenotypes of nontuberculous mycobacterial lung disease (NTM-LD) over a recent 15-year period in Korea. The increase of number of patients with NTM-LD was primarily due to an increase of Mycobacterium avium complex (MAC) lung disease (LD). Among MAC cases, the proportion of M. avium increased compared with M. intracellulare, whereas the incidence of M. abscessus complex and M. kansasii LD remained relatively stable. The proportion of cases of the nodular bronchiectatic form increased compared with the fibrocavitary form of NTM-LD.

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Recovery Rates of Non-Tuberculous Mycobacteria from Clinical Specimens Are Increasing in Korean Tertiary-Care Hospitals

Cited by 25 publications

References 19 publications

Prevalence, incidence, and mortality of nontuberculous mycobacterial infection in Korea: a nationwide population-based study

Prevalence, incidence, and mortality of nontuberculous mycobacterial infection in Korea: a nationwide population-based study

Clinical and microbiological characteristics of non-tuberculous mycobacteria diseases in Singapore with a focus on pulmonary disease, 2012-2016

Changing Epidemiology of Nontuberculous Mycobacterial Lung Diseases in a Tertiary Referral Hospital in Korea between 2001 and 2015

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