Recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin-like growth factor 1 (IGF-1)

Kiryakova, S.; Söhnchen, J.; Grosheva, Maria; Schuetz, U.; Marinova, Ts-S.; Dzhupanova, Ralitsa S.; Sinis, Nektarios; Hübbers, CU; Skouras, Emmanouil; Ankerne, Janina; Fries, Jochen W.U.; Irintchev, Andrey; Dunlop, Sarah; Angelov, Doychin N.

doi:10.1016/j.expneurol.2009.12.031

Cited by 29 publications

(17 citation statements)

References 89 publications

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“…Royal College of Surgeons (RCS) dystrophic rats were used in this study, in place of a more standard laboratory strain, for the reason that RCS rats have proved to be a useful model animal for investigating the rat vibrissal system (Brecht, Preilowski, & Merzenich, 1997;Grant et al, 2009;Kiryakova et al, 2010;Mitchinson et al, 2007). The retinal dystrophy exhibited in adult animals allows experimental control of the availability of information through vision without blindfolding, surgery, or the use of infrared illumination.…”

Section: Limitations and Future Workmentioning

confidence: 99%

The development of whisker control in rats in relation to locomotion

Grant

Mitchinson

Prescott

2011

Developmental Psychobiology

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Adult rats sweep their large facial whiskers (macrovibrissae) back and forth in a rhythmic pattern known as "whisking". Here we examine how these whisker movements develop in relation to other aspects of exploratory behavior, particularly locomotion. We analyzed 963 high-speed video recordings of neonatal rats, from P1 (Post-natal day 1) to P21, and measured the emergence of whisker control and of head, body, and limb movements. Prior to P11, whisker movements were largely limited to unilateral retractions accompanying head turns. Between P11 and P13 bilateral whisking emerged alongside increased forward locomotion and improved control of the head. Contact-induced modulations of whisking symmetry, synchrony, and whisker spread emerge shortly thereafter but continue to develop until at least P18, coinciding with the emergence of adult-like locomotion patterns such as rearing. Overall, whisking develops alongside increasing locomotor competence indicating that active vibrissal sensing plays an important role in the exploratory behavior of the developing animal.

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Section: Limitations and Future Workmentioning

confidence: 99%

The development of whisker control in rats in relation to locomotion

Grant

Mitchinson

Prescott

2011

Developmental Psychobiology

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“…Kiryakova et al 252 concluded that IGF-I is required to mediate the effects of MS on target muscle reinnervation and recovery of whisking function. …”

Section: Recovery Of Whisking Function Promoted By Manual Stimulationmentioning

confidence: 99%

Experimental studies on post-transectional facial nerve regrowth and functional recovery of paralyzed muscles of the face in rats and mice

Skouras¹,

Angelov²

2010

Anatomy

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The facial nerve is the most frequently damaged nerve in head and neck traumata. Apart from traffic-accident injuries (temporal bone fractures, or lacerations of the face), most facial nerve lesions are post-operative AbstractInsufficient recovery after peripheral nerve injury has been attributed to (i) lack of axonal navigation and poor pathfinding of regrowing axons to improper targets, (ii) excessive collateral axonal branching at the lesion site and (iii) polyneuronal reinnervation of the neuromuscular junctions (NMJ). The facial nerve transection model in rat and mice has been used to measure the restoration of function after varying therapies and to examine the mechanisms underlying their effects. Since it is still very difficult to combat the first reason and control/correct the navigation of several thousand axons, several groups of scientists concentrated our efforts on the postlesional branching (extremely strong in adult rats) and NMJ-polyinnervation. Since polyneuronal innervation of muscle fibers is activity-dependent attempts to reduce it were performed applying electrical stimulation. Unfortunately, the highly recommended intraoperative electrical stimulation of the proximal nerve fragment (square 0.1 ms pulses at 20 Hz using suprathreshold amplitudes) prior to suture and the postoperative electrical stimulation (square 0.1 ms pulses at 5 Hz) not only did not improve functional outcome, but reduced the number of innervated NMJ to approximately one fifth of normal values. Finally, recent experiments demonstrated that it was the mechanical (but not electrical) stimulation of denervated facial muscles (vibrissal and orbicularis oculi) which improved motor performance. This beneficial effect of mechanical stimulation was also detected after hypoglossal-facial anastomosis and inter-positional nerve grafting. The beneficial effect of manual stimulation on target muscle reinnervation was not present in mice deficient in the expression of insulin-like growth factor 1 and also eliminated or even reversed when trigeminal afferent inputs were abolished. All these findings raise hopes that clinically feasible and effective therapies could be soon designed and tested.

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“…Studies on IGF-1 have predominantly focused on diseases such as diabetes, osteoporosis and Alzheimer's disease (3)(4)(5). A number of animal studies have investigated the role of IGF-1 in the treatment of peripheral nerve injuries (6)(7)(8), including injuries involving the facial nerves and sciatic nerve. However, studies investigating the effects of IGF-1 on the pathological changes of spinal motor neurons following peripheral nerve injury are less common.…”

Section: Introductionmentioning

confidence: 99%

Effect of transgenic human insulin-like growth factor-1 on spinal motor neurons following peripheral nerve injury

Gu¹,

Liu²,

Zhang³

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to observe the protective effect of exogenous human insulin-like growth factor-1 (hIGF-1) on spinal motor neurons, following its local transfection into an area of peripheral nerve injury. A total of 90 male Wistar rats that had been established as sciatic nerve crush injury models were randomly divided into three groups: hIGF-1 treatment, sham-transfected control and blank control groups. The different phases of hIGF-1 expression were observed in the spinal cord via postoperative immunostaining and the apoptosis of motor neurons was observed using the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method. Pathological changes of the motor neurons and Nissl bodies within cell bodies were observed via Marsland and Luxol fast blue double staining, while changes in the neuropil of the spinal cord anterior horn were investigated via ultrastructural observation. It was found that hIGF-1, locally transfected into an area of peripheral nerve injury, was expressed in the spinal anterior horn following axoplasmic transport; the peak hIGF-1 expression occurred approximately a week following transfection. The number of apoptotic spinal cord motor neurons observed in the hIGF-1 treatment group was fewer than that in the sham-transfected and blank control groups at days 7, 14 and 21 following transfection (P<0.01). Furthermore, the quantity of motor neuron cells in the anterior horn of the spinal cord in the hIGF-1 treatment group was higher compared with those in the sham-transfected and blank control groups at days 2, 7, 14 and 28 following transfection (P<0.01). The degenerative changes of Nissl bodies within the cytoplasm of the hIGF-1 treatment group were less severe compared with those of the sham-transfected and blank control groups. At day 56 following transfection, the spinal anterior horn neuropil ultrastructure in the hIGF-1 treatment group was generally normal, while the sham-transfected and blank control groups exhibited an increased number of protruding gaps and local cavities. These results indicate that the application of exogenous hIGF-1 is capable of protecting spinal cord motor neurons following peripheral nerve injury.

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Recovery of whisking function promoted by manual stimulation of the vibrissal muscles after facial nerve injury requires insulin-like growth factor 1 (IGF-1)

Cited by 29 publications

References 89 publications

The development of whisker control in rats in relation to locomotion

The development of whisker control in rats in relation to locomotion

Experimental studies on post-transectional facial nerve regrowth and functional recovery of paralyzed muscles of the face in rats and mice

Effect of transgenic human insulin-like growth factor-1 on spinal motor neurons following peripheral nerve injury

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