Recovery of the precision grip in children after traumatic brain injury

Gölge, Mukaddes; Müller, Mario; Dreesmann, Mona; Hoppe, Birgit; Wenzelburger, Roland; Kuhtz-Buschbeck, Johann P.

doi:10.1016/j.apmr.2003.11.029

Cited by 15 publications

(4 citation statements)

References 23 publications

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“…The grip strength test is included in the functional observational battery for use in the neurotoxicity studies in rodents to access neuromotor function [76]. In addition, clinical data indicate that grasping is impaired in children after TBI [77], and the quantitative analysis of precision-grip forces has been proposed as a sensitive method to assess recovery of fine motor skills [77,78]. Our data indicate a significant decrease in grip strength following CCI, and the decrease in grip strength was three-fold less in the AL-8810-treated group, which suggests that the FP receptor blockade might protect neuromotor function or facilitate its recovery following CCI.…”

Section: Discussionmentioning

confidence: 99%

Prostaglandin F2α FP receptor antagonist improves outcomes after experimental traumatic brain injury

Glushakov

Robbins

Bracy

et al. 2013

J Neuroinflammation

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BackgroundInjuries to the brain promote upregulation of prostaglandins, notably the proinflammatory PGF2α, and overactivation of their cognate G-protein-coupled FP receptor, which could exacerbate neuronal damage. Our study is focused on investigation of the FP receptor as a target for novel neuroprotective drugs in a preclinical animal traumatic brain injury (TBI) model.MethodsAccordingly, the effects of acute intraperitoneal post-treatment with selective FP antagonist AL-8810 were studied in wildtype (WT) and FP receptor knockout (FP-/-) mice after controlled cortical impact (CCI). Neurological impairments were evaluated using neurological deficit scores (NDS) and the grip strength test. Cortical lesions and overall brain pathology were assessed using immunohistochemistry.ResultsMorphological analyses of cerebral vasculature and anastomoses revealed no differences between WT and FP-/- mice. CCI produced cortical lesions characterized by cavitation, neuronal loss, and hematoma with a volume of 20.0 ± 1.0 mm3 and significant hippocampal swelling (146.5 ± 7.4% of contralateral) compared with sham (P < 0.05). Post-treatment with AL-8810 (1 to 10 mg/kg) had no significant effect on cortical lesions, which suggests the irreversible effect of primary CCI injury, but significantly reduced hippocampal swelling to a size not significantly different from the sham group. Post-treatment with AL-8810 at a dose of 10 mg/kg significantly improved NDS at 24 and 48 hours after CCI (P < 0.001 and P < 0.01, respectively). In the AL-8810 group, CCI-induced decrease in grip strength was three-fold (2.93 ± 1.71) less and significantly different than in the saline-treated group. The FP-/- mice had significantly less hippocampal swelling, but not NDS, compared with WT mice. In addition, immunohistochemistry showed that pharmacologic blockade and genetic deletion of FP receptor led to attenuation of CCI-induced gliosis and microglial activation in selected brain regions.ConclusionThis study provides, for the first time, demonstration of the unique role of the FP receptor as a potential target for disease-modifying CNS drugs for treatment of acute traumatic injury.

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Section: Discussionmentioning

confidence: 99%

Prostaglandin F2α FP receptor antagonist improves outcomes after experimental traumatic brain injury

Glushakov

Robbins

Bracy

et al. 2013

J Neuroinflammation

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“…Studies indicate that upper-extremity weakness, spasticity, and abnormal motor synergies are insufficient to explain the impairment in reaching movements after stroke (Roby-Brami et al, 1997;Twitchell, 1959;Wing et al, 1990), and suggest that additional higher-order control deficits may be present (Beer et al, 1999). Impairments in execution of precision grasp after damage to the primary motor cortex or corticospinal tract have been extensively described in non-human and human primates (Aruin, 2005;Denny-Brown, 1966;Duque et al, 2003;Golge et al, 2004;Grichting et al, 2000;Hepp-Reymond, 1988;Hepp-Reymond and Wiesendanger, 1972;Hermsdörfer et al, 2003;Hermsdörfer and Mai, 1996;Lawrence and Kuypers, 1968;Muir and Lemon, 1983;Porter and Lemon, 1993;Quaney et al, 2005;Wenzelburger et al, 2005). However, it has not been established whether higher-order abnormalities in precision grasp are present after stroke, comparable to those found in reaching (Beer et al, 1999;Takahashi and Reinkensmeyer, 2003).…”

Section: Introductionmentioning

confidence: 99%

Impaired anticipatory control of fingertip forces in patients with a pure motor or sensorimotor lacunar syndrome

Raghavan

2006

Brain

109

102

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We examined planning and execution of precision grasp in eight right-handed patients with a right pure motor or sensorimotor lacunar syndrome after a subcortical stroke and eight age-matched controls as they grasped and lifted an instrumented object whose weight could be varied without altering its visual appearance. Grip (normal) and load (tangential) forces at the fingertip-object interface were measured and the grip force rate (GFR) and load force rate (LFR) were derived. Planning of precision grasp was assessed by measurement of anticipatory scaling of peak GFR and peak LFR to object weight. Execution of precision grasp was assessed by measurement of both the timing and efficiency of grip-load force coordination: the pre-load phase duration (PLD) and the load phase duration (LPD) measured timing, whereas the grip force at load force onset (GFO) and the grip force at lift-off (GFL) measured efficiency. Subjects lifted a light and heavy object five times first with the RIGHT hand, then with the LEFT hand, and then once more with the RIGHT AFTER LEFT hand. Patients with stroke did not scale the peak LFR or peak GFR to object weight with the RIGHT hand even with repeated attempts; however, they scaled the peak LFR to object weight on the first lift with the RIGHT AFTER LEFT hand (P = 0.01). Patients also prolonged the PLD and LPD and produced excessive GFO and GFL for RIGHT hand lifts, but decreased the GFL for the heavy object (P = 0.016) with the RIGHT AFTER LEFT hand. Correlation of precision grasp variables from lifts with the RIGHT hand with clinical measures showed that anticipatory scaling of peak LFR and peak GFR did not correlate with clinical measures of hand function, whereas the PLD did (r = 0.88, P = 0.004). The results suggest that patients with right hemiparesis from a subcortical lesion of the corticospinal tract have a higher-order motor planning deficit. This planning deficit is dissociable from deficits in motor execution, is not captured by routine clinical assessment, and is correctable by transfer of information from the unaffected hemisphere. A rehabilitation strategy that involves practice with the left hand prior to practice with the right hand may improve planning of grasping behaviour in patients with right hemiparesis.

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“…To lift the device, participants used a pincer-style grip also known as a precision grip [ 9 – 11 ], similar to the thumb and forefinger grip commonly used to hold a scalpel handle. Participants were required to wash their hands to remove sweat and oily substances as required for the Grip-Lift task [ 9 , 12 ]. Methods employed were similar to those reported by McDonnell et al [ 13 ] and Todd et al [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

Measuring dexterity in the podiatrist population: a cross-sectional comparison of novice students and experienced podiatrists

et al. 2018

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BackgroundThere is no ‘gold-standard’ for the evaluation of dexterity for the health professional or podiatrist populations. This has resulted in a broad array of generalised tests to evaluate dexterity. Thus, the aim was to determine which objective generalised dexterity tests are best suited to evaluating dexterity in a podiatry student population.MethodsA cohort of Novice podiatry students and Experienced podiatrists were recruited and evaluated on a battery of dexterity tests selected to evaluate a variety of different elements. Group differences were evaluated statistically and regression undertaken on significant test outcomes.ResultsA total of 108 participants were recruited with 54 participants in each of the Novice and Experienced groups. Five of the eight tests were able to discriminate dexterous ability of participants in the Novice and Experienced groups. These included the Grip-lift task, GPT, P-MVC, G-MVC and the AsTex® sensory discrimination test. These tests comprised a total of 11 significant dependent variables (p < 0.05). From the test battery, outcomes were able to predict 79% of the group membership. Age and experience did not explain within-group variability for the Experienced group.ConclusionWhilst the Experienced group displayed superior performance in strength and speed, the Novice group showed superior coordination and sensory ability. From these findings, we would recommend that outcomes from the Grooved Pegboard Test, Grip-lift task, Grip Strength test and Pinch Grip strength test be used to evaluate elements of dexterity in this population.Electronic supplementary materialThe online version of this article (10.1186/s12909-018-1276-1) contains supplementary material, which is available to authorized users.

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Recovery of the precision grip in children after traumatic brain injury

Cited by 15 publications

References 23 publications

Prostaglandin F2α FP receptor antagonist improves outcomes after experimental traumatic brain injury

Prostaglandin F2α FP receptor antagonist improves outcomes after experimental traumatic brain injury

Impaired anticipatory control of fingertip forces in patients with a pure motor or sensorimotor lacunar syndrome

Measuring dexterity in the podiatrist population: a cross-sectional comparison of novice students and experienced podiatrists

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