Recovery of T‐cell subsets after antiretroviral therapy in HIV‐infected children

Abstract

Recovery of the CD4+ T-cell percentage induced by ART reflects a reduction in the chronic immune activation and a measurable reconstitution of the immune system and depends on naive CD4+ T cells.

HAART and Causes of Death in Perinatally HIV-1-Infected Children

“…Among the therapy-naïve paediatric patients enrolled in the HIV Paediatric Cohort of the Comunidad Autónoma de Madrid, poor adherence has been identified as primary risk factor for initial HAART regimens discontinuation and short duration. This result is in agreement with the association between adherence and response to antiretroviral therapy reported for paediatric patients, being incomplete adherence the primary cause of treatment failure (Chiappini et al, 2006;Gray et al, 2001;Hainaut et al, 2003;Resino et al, 2003). In addiction, the age at HAART initiation was found to be another independent risk factor for first HAART regimen discontinuation.…”

Combined antiretroviral therapy reduces hyperimmunoglobulinemia in HIV-1 infected children

“…T-lymphocyte reconstitution with combined-ART has been extensively documented [16][17][18][19], but limited data are yet available on the effects on B-lymphocyte function and Ig concentrations. To our knowledge, this is the longest reported observation on the effects of combined-ART on HIV-1 induced hyperimmunoglobulinemia and the only study on children.…”

Supranormal thymic output up to 2 decades after HIV-1 infection

“…However, these measurements have not excluded qualitative abnormalities in thymopoiesis that might result from the known impact of HIV-1 on the architecture of both the thymus and secondary lymphoid tissues. [13-15, 20-22]…”