Recovery of systemic hyperinflammation in patients with severe SARS-CoV-2 infection

Langnau, Carolin; Janing, Henrik; Kocaman, Hüseyin; Gekeler, Sarah; Günter, Manina; Petersen, Álvaro; Jaeger, Philippa; Koch, Barbara; Kreißelmeier, Klaus-Peter; Castor, Tatsiana; Rath, Dominik; Gawaz, Meinrad; Autenrieth, Stella E.; Mueller, Karin

doi:10.1080/1354750x.2022.2148745

Cited by 1 publication

(1 citation statement)

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“…The proinflammatory effects of MIF and D-DT make these cytokines potential important players in the cascade of immunoinflammatory events that may lead to the several complications during SARS-CoV-2 infection and propel studies aimed at determining its role both as a pathogenetic and diagnostic cytokine and to eventually design and develop tailored therapeutic approaches [28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Role of CD74 and D-Dopachrome Tautomerase in COVID-19: Insights from Transcriptomic and Serum Analyses

Ralchev Ralchev,

Lyubenova Bradyanova,

Valerieva Doneva

et al. 2023

JCM

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The COVID-19 pandemic has posed a significant threat to public health worldwide. While some patients experience only mild symptoms or no symptoms at all, others develop severe illness, which can lead to death. The host immune response is believed to play a crucial role in determining disease severity. In this study, we investigated the involvement of CD74 and D-DT in COVID-19 patients with different disease severities, by employing an in silico analysis of a publicly available transcriptomic dataset and by measuring their serum levels by ELISA. Our results showed a significant increase in MIF levels in PBMCs from COVID-19 patients, as well as a significant increase in the D-DT levels in PBMCs. However, we observed no modulation in the serum levels of D-DT. We also observed a concordant reduction in the serum levels and PBMCs expression levels of CD74. Furthermore, we found a negative correlation between CD74 serum levels and IL-13. In conclusion, our study sheds light on the involvement of CD74 and D-DT in COVID-19, with potential implications for disease severity and treatment. Further studies are needed to fully elucidate the mechanisms underlying these observations and to explore the potential therapeutic value of targeting CD74 and IL-13 in COVID-19.

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