Recovery of succinic acid produced by fermentation of a metabolically engineered Mannheimia succiniciproducens strain

Song, Hyohak; Huh, Yun Suk; Lee, Sang Yup; Hong, Won Hi; Hong, Yeon Ki

doi:10.1016/j.jbiotec.2007.07.496

Cited by 74 publications

(47 citation statements)

References 27 publications

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“…This difference must influence the quality of the final purified product. A similar effect was reported for the recovery of succinic acid from the culture broth of a metabolically engineered Mannheimia succiniciproducens strain, employing an advanced strain contributed to the simplification of the purification process and lead to an increase in the purity of the desired product (17).…”

supporting

confidence: 55%

Simple and efficient isolation of cordycepin from culture broth of a Cordyceps militaris mutant

Masuda

Hatashita

Fujihara

et al. 2015

Journal of Bioscience and Bioengineering

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supporting

confidence: 55%

Simple and efficient isolation of cordycepin from culture broth of a Cordyceps militaris mutant

Masuda

Hatashita

Fujihara

et al. 2015

Journal of Bioscience and Bioengineering

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“…For the reactive extraction of succinic acid from an aqueous phase, long-chain aliphatic primary, secondary and tertiary amines are proposed (Tung and King 1994a;Hong and Hong 2000a, b, c;Hong et al 2002Song et al 2007).…”

Section: Reactive Extractionmentioning

confidence: 99%

“…In the literature mostly simple reactive extraction systems with tertiary amines in alcohol, xylene, heptane, kerosene, methylenchloride or nitrobenzene are described for the extraction of succinic acid from an aqueous solution (Hong and Hong 2000a, b, c;Juang et al 1997;Tung and King 1994a;Yang et al 1991, Song et al 2007). For example, Song et al (2007) proposed a simple process of reactive extraction with trioctylamine in 1-octanol, vacuum distillation and crystallization.…”

Section: Reactive Extractionmentioning

confidence: 99%

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Recovery of succinic acid from fermentation broth

2009

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Succinic acid is of high interest as bio-feedstock for the chemical industry. It is a precursor for a variety of many other chemicals, e.g. 1,4-butandiol, tetrahydrofuran, biodegradable polymers and fumaric acid. Besides optimized production strains and fermentation processes it is indispensable to develop cost-saving and energy-effective downstream processes to compete with the current petrochemical production process. Various methods such as precipitation, sorption and ion exchange, electrodialysis, and liquid-liquid extraction have been investigated for the recovery of succinic acid from fermentation broth and are reviewed critically here.

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“…A variety of different downstream processing methods for bio-succinic acid, like precipitation with calcium hydroxide or ammonium, electrodialysis, ion exchange and adsorption, crystallisation and liquid-liquid extraction have been reviewed recently [7]. Most of these separation technologies showed low selectivities and/or low yields with the exception of reactive extraction with high molecular weight amines solved in non-water-miscible organic solvents [8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

New reactive extraction systems for separation of bio-succinic acid

Kurzrock

Weuster‐Botz

2011

Bioprocess Biosyst Eng

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Biotechnologically produced succinic acid has the potential to displace maleic acid and its uses and to become an important feedstock for the chemical industry. In addition to optimized production strains and fermentation processes, an efficient separation of succinic acid from the aqueous fermentation broth is indispensable to compete with the current petrochemical production processes. In this context, high molecular weight amines are known to be effective extractants for organic acids. For this reason, as a first step of isolation and purification, the reactive extraction of succinic acid was studied by mixing aqueous succinic acid solutions with 448 different amine-solvent mixtures as extraction agents (mixer-settler studies). The extraction agents consist either of one amine and one solvent (208 reactive extraction systems) or two amines and two solvents (240 reactive extraction systems). Maximum extraction yields of succinic acid from an aqueous solution with 423 mM succinic acid at pH 2.0 were obtained with more than 95% yield with trihexylamine solved in 1-octanol or with dihexylamine and diisooctylamine solved in 1-octanol and 1-hexanol. Applying these optimized reactive extraction systems with Escherichia coli fermentation broth resulted in extraction yields of 78-85% due to the increased ionic strength of the fermentation supernatant and the co-extraction of other organic acids (e.g., lactic acid and acetic acid), which represent typical fermentation byproducts.

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Recovery of succinic acid produced by fermentation of a metabolically engineered Mannheimia succiniciproducens strain

Cited by 74 publications

References 27 publications

Simple and efficient isolation of cordycepin from culture broth of a Cordyceps militaris mutant

Simple and efficient isolation of cordycepin from culture broth of a Cordyceps militaris mutant

Recovery of succinic acid from fermentation broth

New reactive extraction systems for separation of bio-succinic acid

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