Recovery of sperm production following the cessation of gossypol treatment: a two‐centre study in China

Meng, Guofeng; Zhu, Jian; Chen, Z.-W.; Wong, Lorrie; Zhang, G.-Y.; Hu, Yanqin; Ding, J.-H.; Wang, X.-H.; Qian, S. J.; Wang, Christina; Manchin, D.; Pinol, A.; Waites, G. M. H.

doi:10.1111/j.1365-2605.1988.tb01211.x

Cited by 21 publications

(6 citation statements)

References 9 publications

(4 reference statements)

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“…[1617] However, in at least one-fifth of the patients, the effect was irreversible. [18] Other significant dose-dependent side effects included hypokalemia and periodic paralysis. [19]…”

Section: Other Non-hormonal Methods Of Contraceptionmentioning

confidence: 99%

Male contraception

Mathew

Bantwal

2012

Indian J Endocr Metab

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Contraception is an accepted route for the control of population explosion in the world. Traditionally hormonal contraceptive methods have focused on women. Male contraception by means of hormonal and non hormonal methods is an attractive alternative. Hormonal methods of contraception using testosterone have shown good results. Non hormonal reversible methods of male contraception like reversible inhibition of sperm under guidanceare very promising. In this article we have reviewed the current available options for male contraception.

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“…[1617] However, in at least one-fifth of the patients, the effect was irreversible. [18] Other significant dose-dependent side effects included hypokalemia and periodic paralysis. [19]…”

Section: Other Non-hormonal Methods Of Contraceptionmentioning

confidence: 99%

Male contraception

Mathew

Bantwal

2012

Indian J Endocr Metab

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“…The second major concern raised by a group of researchers was the lack of complete reversibility. A long-term follow-up study of men who had taken gossypol as a male contraceptive showed that only 61% of them regained fertility after they stopped taking the compound; however, 22% remained azoospermic (absence of sperm in the semen) even three years after they stopped taking gossypol [26].…”

Section: B Non-hormonal Agents (Plant-derived Compounds)mentioning

confidence: 97%

Male Contraception: An Overview of the Potential Target Events

Tulsiani¹,

Abou-Haïla²

2008

EMIDDT

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The contraceptive options available to men have not changed in several decades and are still limited to the non-surgical methods of the use of a condom, a timely withdrawal, or a surgical procedure that removes a segment of the vas deferens (vasectomy). The first two approaches have relatively higher failure rates whereas the last approach is largely irreversible and may not be suitable for younger men. Thus, providing a safe, effective and readily available contraception for men has remained an unfulfilled goal. In this article, we intend to review the current status of the research and development on male contraceptives. It is apparent that the scientific community in the past few decades has witnessed impressive progress in understanding the basics of male physiology, the knowledge necessary for developing new contraceptive methods for men. We will highlight various new and improved strategies for the regulation of fertility in males. The diverse approaches that are at various stages of development and/or in clinical trials include: 1) administration of hormones, herbal extracts or chemicals to suppress/arrest sperm production in the testes (spermatogenesis); 2) interference with the delivery of spermatozoa during ejaculation by targeted blockage of vas deferens with plugs or chemicals (polymers) that prevent flow of sperm through the vas duct; 3) active or passive immunization of males with well characterized antigens/antibodies which are intended to block sperm function; and 4) administration of site-directed antagonists to block specific sperm function(s) necessary for normal fertilization. All these approaches do not involve surgery and are reversible. Our intention is to discuss the current status of various approaches which show promising results in clinical trials, particularly in China and India, the world's most populous nations.

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“…A reported longer duration of use of gossypol was 9 years ( Hu et al ., 1987 ). While the duration of gossypol treatment ranged from 0.6 to 9.2 years, corresponding total doses ranged from 2.5 to 27.5 g ( Meng et al ., 1988a ,b). In another study, 32 men had taken gossypol acetic acid for 6–10 years ( Xu et al ., 1988 )!…”

Section: Irreversible Azoospermiamentioning

confidence: 99%

Gossypol as a male antifertility agent – why studies should have been continued

Chan

1998

Int J of Andrology

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It has been nearly three decades since the beginning of nationwide research into gossypol as a male antifertility agent in China. Several lines of data implicating some side effects of gossypol were published which led to the termination of this area of research in China. The present review re-examines these data and points out the confusion surrounding issues such as hypokalaemia, irreversible azoospermia and other side effects. The prospects and related difficulties for gossypol as a potential male contraceptive are also discussed.

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Recovery of sperm production following the cessation of gossypol treatment: a two‐centre study in China

Cited by 21 publications

References 9 publications

Male contraception

Male contraception

Male Contraception: An Overview of the Potential Target Events

Gossypol as a male antifertility agent – why studies should have been continued

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