Recovery of serum testosterone following neoadjuvant and adjuvant androgen deprivation therapy in men treated with prostate brachytherapy

Abstract

Lower T levels at cessation of ADT were associated with prolonged T recovery in the long-term usage group. Five years after cessation of long-term ADT, approximately one-fifth of patients still had castrate T levels. When determining the therapeutic effect, especially biochemical control, we should consider this delay in T recovery.

Impact of five‐tiered Gleason grade groups on prognostic prediction in clinical stage T3 prostate cancer undergoing high‐dose‐rate brachytherapy

“…We did not eliminate those influences of stage migration on the prognostic value. Second, technical modifications for the radiotherapy, different duration of neoadjuvant ADT, different types of nonsteroidal anti‐androgen agents, and sustained castration testosterone levels after cessation of long‐term ADT may have influenced the interpretation of the data . Third, patients who were diagnosed before the 2005 ISUP consensus conference was proposed were included in this study.…”

“…Second, technical modifications for the radiotherapy, 31 different duration of neoadjuvant ADT, different types of nonsteroidal anti-androgen agents, and sustained castration testosterone levels after cessation of long-term ADT may have influenced the interpretation of the data. 32 Third, patients who were diagnosed before the 2005 ISUP consensus conference was proposed were included in this study. Although our pathologists never assigned a Gleason score of 2-4 for the biopsy specimens and were early adopters of the grading system, Gleason grade migration was likely to occur in some patients as a result of the proposal.…”

Duration of androgen deprivation therapy and nadir of testosterone at 20 ng/dL predict testosterone recovery to supracastrate level in prostate cancer patients who received external beam radiotherapy

“…This is considered to occur because the feedback system of the hypothalamic–pituitary axis responded normally to the low TST levels after termination of ADT. Past studies reported that older age was a significant factor associated with slower TST recovery . Other studies showed that the production of TST decreases with age .…”

“…Past studies reported that older age was a significant factor associated with slower TST recovery. 14,16,17 Other studies showed that the production of TST decreases with age. 18,19 This decline might be related to later TST recovery in older men treated with ADT.…”

“…22 Tsumura et al reported TST recovery after termination of long-term ADT with prostate brachytherapy, and they found that TST at the termination of ADT predicted TST recovery. 16 It is not clear how brachytherapy influences TST levels, but TST recovery after termination of ADT depends mainly on ADT duration, independent of the type of radiation therapy. ADT has significant adverse effects, including hot flushes, decreased libido, loss of bone density and muscles, and possible cardiovascular events.…”