Recovery of Pulmonary Function in Farmer's Lung: A Five-year Follow-up Study

Kokkarinen, Jouko; Tukiainen, H; Terho, E. O.

doi:10.1164/ajrccm/147.4.793

Cited by 73 publications

(45 citation statements)

References 13 publications

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“…In our study the prevalence of asthma was low before the onset of farmer's lung and there was an increased incidence of asthma during the first years after an episode of farmer's lung. This finding confirms previous findings with smaller groups of patients (3)(4)(5).…”

Section: Discussionsupporting

confidence: 93%

“…The proportion of smokers among farmer's lung patients is low (3,7,12). The mean age and gender distribution of farmer's lung patients in this study were close to those of 2 other Finnish follow-up studies (3,7).…”

Section: Discussionsupporting

confidence: 80%

“…However, some farmer's lung patients may also show an obstructive pattern in inhalation challenge with moldy hay or other offending antigens (1,2). In a few studies asthma has also been reported in 7% to 18% of patients during follow-up after an episode of farmer's lung (3)(4)(5).…”

mentioning

confidence: 99%

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Asthma in patients with farmer's lung during a five-year follow-up

Kokkarinen

H²,

Terho³

1997

Scand J Work Environ Health

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Objectives This study assessed the incidence of asthma in patients with farmer's lung. Methods The study population consisted of 103 1 patients who had occupational fanner's lung diagnosed from 1983 to 1988. The cases of farmer's lung were registered in the nationwide Register of Occupational Diseases by the Finnish Institute of Occupational Health, and all the patients in the study had received compensation from the insurance company for an occupational disease. The diagnosis of asthma was based on entitlement to a special refund for asthma medication costs from the national sickness insurance program. Results Seventy-four cases of asthma were found among farmers with farmer's lung up to the end of the 5 years following the year of the diagnosis for farmer's lung. The prevalence of asthma was 1 % in the year preceding the diagnosis. In the year of the diagnosis and during the 5 years of follow-up, asthma was diagnosed in an additional 6% of the patients. C O~C~U S~O~~S The results of this study confirm previous findings of a low prevalence of asthma before the onset of farmer's lung in small groups of patients. However, the results also indicate that the incidence of asthma increases during the first years after an episode of farmers lung. For example, in the present study, asthma was apparent in 7% of the patients 5 years after the diagnosis of farmer's lung.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 80%

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Asthma in patients with farmer's lung during a five-year follow-up

Kokkarinen

H²,

Terho³

1997

Scand J Work Environ Health

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“…Nonspecific bronchial hyperresponsiveness [226,227] and wheezing may also be prevalent in subjects with recent hypersensitivity pneumonitis, especially in dairy farmers [228,229].…”

Section: Environmental or Occupational Exposurementioning

confidence: 99%

Small airways diseases, excluding asthma and COPD: an overview

Burgel¹,

Bergeron²,

Blic³

et al. 2013

European Respiratory Review

104

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This review is the summary of a workshop on small airways disease, which took place in Porquerolles, France in November 2011. The purpose of this workshop was to review the evidence on small airways (bronchiolar) involvement under various pathophysiological circumstances, excluding asthma and chronic obstructive pulmonary disease. Histopathological patterns associated with small airways disease were reviewed, including cellular and obliterative bronchiolitis. Many pathophysiological conditions have been associated with small airways disease including airway infections, connective tissue diseases and inflammatory bowel diseases, bone marrow and lung transplantation, common variable immunodeficiency disorders, diffuse panbronchiolitis, and diseases related to environmental exposures to pollutants, allergens and drugs. Pathogenesis, clinical presentation, a computed tomography scan and pulmonary function test findings are reviewed, and therapeutic options are described with the objective of providing an integrative approach to these disorders.

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“…Diffusing capacity of the lung for carbon dioxide is usually the slowest parameter to improve; defects in diffusing capacity of the lung for carbon dioxide may persist depending on stage of disease at diagnosis. 40,41 Smoking may also negatively influence outcome. 42 Vourlekis et al 33 also demonstrated that older age, smoking, and fibrosis all contribute to increased mortality compared with patients with nonhypersensitivity pneumonia.…”

Section: Commentmentioning

confidence: 99%

Hypersensitivity Pneumonia: Role of Surgical Lung Biopsy

Herbst

2012

Archives of Pathology &Amp; Laboratory Medicine

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Lung biopsy often plays a key role in identifying patients with hypersensitivity pneumonia, especially in the absence of a typical history. A 69-year-old woman with a 2-year history of unexplained dyspnea on exertion underwent surgical lung biopsy for diagnosis of diffuse lung disease thought to represent idiopathic pulmonary fibrosis. Her biopsy showed honeycomb change and fibroblast foci suggestive of usual interstitial pneumonia, but also showed areas of cellular interstitial pneumonia with chronic bronchiolitis and a pattern of granulomatous inflammation typical of hypersensitivity pneumonia. The classic features of hypersensitivity pneumonia in surgical lung biopsy are emphasized, including a bronchiolocentric cellular interstitial pneumonia, chronic bronchiolitis, and poorly formed nonnecrotizing granulomas. As illustrated in our patient, sometimes subtle histologic clues are key in separating hypersensitivity pneumonia from usual interstitial pneumonia and other forms of idiopathic interstitial pneumonia. Making the distinction is important given differences in treatment strategies and natural history.

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Recovery of Pulmonary Function in Farmer's Lung: A Five-year Follow-up Study

Cited by 73 publications

References 13 publications

Asthma in patients with farmer's lung during a five-year follow-up

Asthma in patients with farmer's lung during a five-year follow-up

Small airways diseases, excluding asthma and COPD: an overview

Hypersensitivity Pneumonia: Role of Surgical Lung Biopsy

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