Recovery of premorbid BMI trajectory without overshoot during the first year of treatment of children with type 1 diabetes

Grönberg, Annika; Swenne, Ingemar

doi:10.1136/bmjdrc-2016-000209

Cited by 1 publication

(1 citation statement)

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“…A relative insulin deficiency preceding the diagnosis of T1D is manifested in most children by a lack of expected weight gain, or even weight loss, during a period of several months before the diagnosis . This subclinical, relative insulin deficiency can be unmasked by an infection, which further increases insulin resistance and pushes the balance toward overt T1D and the requirement for exogenous insulin administration (Figure ).…”

Section: Total β‐Cell Volume Governs Who Will Be Affected By T1dmentioning

confidence: 99%

Aetiology of type 1 diabetes: Physiological growth in children affects disease progression

Skog

Korsgren

2017

Diabetes Obesity Metabolism

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The prevailing view is that type 1 diabetes (T1D) develops as a consequence of a severe decline in β-cell mass resulting from T-cell-mediated autoimmunity; however, progression from islet autoantibody seroconversion to overt diabetes and finally to total loss of C-peptide production occurs in most affected individuals only slowly over many years or even decades. This slow disease progression should be viewed in relation to the total β-cell mass of only 0.2 to 1.5 g in adults without diabetes. Focal lesions of acute pancreatitis with accumulation of leukocytes, often located around the ducts, are frequently observed in people with recent-onset T1D, and most patients display extensive periductal fibrosis, the end stage of inflammation. An injurious inflammatory adverse event, occurring within the periductal area, may have negative implications for islet neogenesis, dependent on stem cells residing within or adjacent to the ductal epithelium. This could in part prevent the 30-fold increase in β-cell mass that would normally occur during the first 20 years of life. This increase occurs in order to maintain glucose metabolism during the physiological increases in insulin production that are required to balance the 20-fold increase in body weight during childhood and increased insulin resistance during puberty. Failure to expand β-cell mass during childhood would lead to clinically overt T1D and could help to explain the apparently more aggressive form of T1D occurring in growing children when compared with that observed in affected adults.

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Section: Total β‐Cell Volume Governs Who Will Be Affected By T1dmentioning

confidence: 99%