Recovery of Organic Acids from Fermentation Broth Using Nanofiltration Technologies: A Review

Zaman, Nadiah Khairul; Law, Jeng Yih; Chai, P.V.; Rohani, Rosiah; Mohammad, Abdul Wahab

doi:10.21315/jps2017.28.s1.6

Cited by 27 publications

(6 citation statements)

References 39 publications

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“…High-value organic acids can be produced from fermentation of biomass and the primary challenge is the downstream recovery of them. NF has been employed for the recovery of succinic, lactic, butyric, acetic and fumaric acids [225]. Sosa et al evaluated different NF membranes (Filmtec NF270 from Dow and NF-DK and NF-DL from GE Osmotics), achieving fluxes between 25 and 32 L•m −2 h −1 and succinate rejections above 90% and reaching negative rejections for acetate and formate [226].…”

Section: Biorefinerymentioning

confidence: 99%

Advances and Applications of Hollow Fiber Nanofiltration Membranes: A Review

Sewerin¹,

Elshof²,

Matencio

et al. 2021

Membranes

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Hollow fiber nanofiltration (NF) membranes have gained increased attention in recent years, partly driven by the availability of alternatives to polyamide-based dense separation layers. Moreover, the global market for NF has been growing steadily in recent years and is expected to grow even faster. Compared to the traditional spiral-wound configuration, the hollow fiber geometry provides advantages such as low fouling tendencies and effective hydraulic cleaning possibilities. The alternatives to polyamide layers are typically chemically more stable and thus allow operation and cleaning at more extreme conditions. Therefore, these new NF membranes are of interest for use in a variety of applications. In this review, we provide an overview of the applications and emerging opportunities for these membranes. Next to municipal wastewater and drinking water processes, we have put special focus on industrial applications where hollow fiber NF membranes are employed under more strenuous conditions or used to recover specific resources or solutes.

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Section: Biorefinerymentioning

confidence: 99%

Advances and Applications of Hollow Fiber Nanofiltration Membranes: A Review

Sewerin¹,

Elshof²,

Matencio

et al. 2021

Membranes

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show abstract

“…However, the boiling point of butyric acid is much higher (163.5 • C) than water (100 • C), so it requires more energy to separate from fermentation broth. To combat energy inefficient recovery, novel efforts are being made to recover butyric acid from fermentation broth [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Butyric Acid Production by Fermentation: Employing Potential of the Novel Clostridium tyrobutyricum Strain NRRL 67062

2022

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In this study, the ability of a novel strain of Clostridium tyrobutyricum NRRL 67062 to produce butyric acid during glucose fermentation was evaluated. The strain was evaluated for substrate and product inhibition in batch experiments using anaerobic tubes. To characterize glucose inhibition, initial glucose concentrations ranging from 60 to 250 g L−1 were used, and it was demonstrated that a glucose concentration of 250 g L−1 exerted strong inhibition on cell growth and fermentation. To evaluate butyric acid inhibition, the culture was challenged with 5–50 g L−1 of butyric acid at an initial pH of 6.5. These experiments were performed without pH control. When challenged with a butyric acid concentration of 50 g L−1, cell growth was slow; however, it produced 8.25 g L−1 of butyric acid. This suggested that the butyric acid tolerance of the culture was 58 g L−1. In a scaled-up batch experiment, which was performed in a 2.5 L fermentor with an initial glucose concentration of 100 g L−1, the pH was controlled at 6.5. In this experiment, the strain produced 57.86 g L−1 of butyric acid and 12.88 g L−1 of acetic acid, thus producing 70.74 g L−1 of total acids with a productivity of 0.69 g·L−1·h−1. A concentration of 70.74 g L−1 of acids equates to a yield of 0.71 g of acid per g consumed glucose. The maximum cell concentration was 3.80 g L−1, which may have been the reason for high productivity in the batch culture. Finally, corn steep liquor (CSL; a commercial nutrient solution) provided greater growth and acid production than the refined medium.

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“…Microfiltration (MF) is an effective method for the removal of microbial biomass, while nanofiltration (NF) efficiently retains proteins and other macromolecules as well as multivalent anions [11,12]. Many researchers have already demonstrated lactic acid separation using NF techniques either from fermentation broths or from defined solutions [13].…”

Section: Introductionmentioning

confidence: 99%

Membrane Technologies for Lactic Acid Separation from Fermentation Broths Derived from Renewable Resources

2018

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Lactic acid (LA) was produced on a pilot scale using a defined medium with glucose, acid whey, sugar bread and crust bread. The fermentation broths were then subjected to micro- and nanofiltration. Microfiltration efficiently separated the microbial cells. The highest average permeate flow flux was achieved for the defined medium (263.3 L/m2/h) and the lowest for the crust bread-based medium (103.8 L/m2/h). No LA losses were observed during microfiltration of the acid whey, whilst the highest retention of LA was 21.5% for crust bread. Nanofiltration led to high rejections of residual sugars, proteins and ions (sulphate, magnesium, calcium), with a low retention of LA. Unconverted sugar rejections were 100% and 63% for crust bread and sugar bread media respectively, with corresponding LA losses of 22.4% and 2.5%. The membrane retained more than 50% of the ions and proteins present in all media and more than 60% of phosphorus. The average flux was highly affected by the nature of the medium as well as by the final concentration of LA and sugars. The results of this study indicate that micro- and nanofiltration could be industrially employed as primary separation steps for the biotechnologically produced LA.

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Recovery of Organic Acids from Fermentation Broth Using Nanofiltration Technologies: A Review

Abstract: To cite this article: Khairul Zaman, N. et al. (2017)

Cited by 27 publications

References 39 publications

Advances and Applications of Hollow Fiber Nanofiltration Membranes: A Review

Advances and Applications of Hollow Fiber Nanofiltration Membranes: A Review

Butyric Acid Production by Fermentation: Employing Potential of the Novel Clostridium tyrobutyricum Strain NRRL 67062

Membrane Technologies for Lactic Acid Separation from Fermentation Broths Derived from Renewable Resources

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