Recovery of orbital fat pad prolapsus and deepening of the lid sulcus from topical bimatoprost therapy: 2 case reports and review of the literature

Abstract

Clinicians and patients should be aware of these possible effects of topical bimatoprost therapy. These adverse effects may not be completely reversible after discontinuation of the medication.

Effects of Prostaglandin F2αon Adipocyte Biology Relevant to Graves' Orbitopathy

“…These positive effects of PGF 2a are not without the balance of some adverse effects. There are emerging case reports of deepening of lid sulcus and/or enophthalmos developing in patients treated with bimatoprost worldwide although in small numbers (2)(3)(4)(5)(6)(7). This side effect is more noticeable if only one eye is exposed to treatment as the treated eye is easily comparable with the unexposed eye.…”

Unilateral Prostaglandin-Associated Periorbitopathy

“…[29][30][31] Since the initial report by Peplinski and Smith, many case series have assessed the effects of PGA use on the ocular adnexa, none of which produce consistent and reproducible orbital and adnexal measurements that fully quantify and qualify PAP. [15][16][17][18][19][20][21][22][23][24][25][26][27][28] Most of these studies were based on either patient or family member's complaints. Interestingly, only 27% of our subjects noticed changes in their eyelids since beginning PGA therapy, and only 15% of these were bothered by these alterations.…”

“…Since then there have been many case reports and series describing PAP. [15][16][17][18][19][20][21][22][23][24][25][26][27][28] These are small studies with varying clinical measurements and are based largely on patient complaints. The histopathologic mechanisms and manifestations of orbital lipolysis have, however, been objectively shown.…”

Prostaglandin İlişkili Periorbitopati: Olgu Sunumu ve Temel Fizyopatolojik Hatırlatma

“…Bimatoprost tedavisi alan 2 hastada benzer klinik tabloyu bildirmişlerdir. 11 Pasquale ise klinik tabloyu prostaglandin ilişkili periorbitopati (PİP) olarak isimlendirmiştir. 12 Biz bu vaka sunumunda uluslararası literatürde az, ulusal literatürde ise hiç değinilmemiş olan bu yan etkiyi topikal Bimatoprost veya Travoprost tedavisi alan 3 olguda bildirmeyi ve ilgili temel fizyopatolojiyi hatırlatmayı istedik.…”