Recovery of Multipotent Progenitors from the Peripheral Blood of Patients Requiring Extracorporeal Membrane Oxygenation Support

Abstract

Hematopoietic, mesenchymal, and epithelial progenitors were mobilized into the circulation of patients on ECMO. This may reflect a response to severe cardiopulmonary injury, blood-foreign surface interactions with the ECMO circuit, and/or hemodilution.

Circulating Endothelial Progenitors and Bone Marrow Derived Cells as Biomarkers for Risk of Bronchopulmonary Dysplasia

“…Mesenchymal stem cells (MSCs) are adult stem cells that are found in the bone marrow [40], cord blood [41] and peripheral blood of human infants with severe acute life threatening respiratory failure who require extracorporeal life support [42]. Intra-pulmonary administration of bone marrow MSCs noticeably decrease inflammatory responses and improve survival in an endotoxin model of lung injury in mice [43].…”

Update in Acute Lung Injury and Critical Care 2010

“…A study in patients requiring extracorporeal membrane oxygenation for life support found that hematopoietic, mesenchymal, and epithelial cell progenitors were mobilized into the circulation, suggesting that progenitor cell mobilization may be a mechanism of nonresident progenitor cell recruitment to injured tissues (73).…”

Extrakorporale Membranoxygenierung (ECMO)

“…Mit Erholung der Lungenfunktion kann die extrakorporale Unterstützung wieder reduziert werden kann. Ob die Mobilisation von pluripotenten Stammzellen, welche aus ECMO-Kreisläufen isoliert werden können, die Reparaturmechanismen in den Patientenlungen unterstützt, ist Gegenstand eines neueren Forschungsansatzes [4]. Wenn bei VA-EC-MO der Blutfluss auf 20% des Herzzeitvolumens reduziert werden kann, ohne dass die systemvenöse Sättigung (S v O 2 ) unter 70% fällt, beginnt die sog.…”