Recovery of motor coordination after exercise is correlated to enhancement of brain-derived neurotrophic factor in lactational vanadium-exposed rats

Wang, Dean-Chuan; Lin, Ying; Lin, Hwai-Ting

doi:10.1016/j.neulet.2015.06.036

Cited by 10 publications

(5 citation statements)

References 28 publications

(35 reference statements)

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“…The pyknotic index in the CA1 region of the low dose vanadium-treated groups was also significantly higher than the control group; this could explain their poor performance in the behavioral tests in comparison to those of the intermediate and high doses. In contrast to these results, previous studies have reported that vanadium exhibits neuroprotective qualities at low doses ( 12 – 15 , 68 – 70 ) and learning and memory deficits at high doses ( 71 – 73 ). Chen et al ( 9 ) suggested that vanadium (oxovanadium hydropolypyrazolylborate complex) at relatively lower doses can improve the learning and memory ability of diabetic mice.…”

Section: Discussioncontrasting

confidence: 88%

Vanadium improves memory and spatial learning and protects the pyramidal cells of the hippocampus in juvenile hydrocephalic mice

Femi-Akinlosotu

Olopade²,

Obiako³

et al. 2023

Front. Neurol.

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BackgroundHydrocephalus is a neurological condition known to cause learning and memory disabilities due to its damaging effect on the hippocampal neurons, especially pyramidal neurons. Vanadium at low doses has been observed to improve learning and memory abilities in neurological disorders but it is uncertain whether such protection will be provided in hydrocephalus. We investigated the morphology of hippocampal pyramidal neurons and neurobehavior in vanadium-treated and control juvenile hydrocephalic mice.MethodsHydrocephalus was induced by intra-cisternal injection of sterile-kaolin into juvenile mice which were then allocated into 4 groups of 10 pups each, with one group serving as an untreated hydrocephalic control while others were treated with 0.15, 0.3 and 3 mg/kg i.p of vanadium compound respectively, starting 7 days post-induction for 28 days. Non-hydrocephalic sham controls (n = 10) were sham operated without any treatment. Mice were weighed before dosing and sacrifice. Y-maze, Morris Water Maze and Novel Object Recognition tests were carried out before the sacrifice, the brains harvested, and processed for Cresyl Violet and immunohistochemistry for neurons (NeuN) and astrocytes (GFAP). The pyramidal neurons of the CA1 and CA3 regions of the hippocampus were assessed qualitatively and quantitatively. Data were analyzed using GraphPad prism 8.ResultsEscape latencies of vanadium-treated groups were significantly shorter (45.30 ± 26.30 s, 46.50 ± 26.35 s, 42.99 ± 18.44 s) than untreated group (62.06 ± 24.02 s) suggesting improvements in learning abilities. Time spent in the correct quadrant was significantly shorter in the untreated group (21.19 ± 4.15 s) compared to control (34.15 ± 9.44 s) and 3 mg/kg vanadium-treated group (34.35 ± 9.74 s). Recognition index and mean % alternation were lowest in untreated group (p = 0.0431, p=0.0158) suggesting memory impairments, with insignificant improvements in vanadium-treated groups. NeuN immuno-stained CA1 revealed loss of apical dendrites of the pyramidal cells in untreated hydrocephalus group relative to control and a gradual reversal attempt in the vanadium-treated groups. Astrocytic activation (GFAP stain) in the untreated hydrocephalus group were attenuated in the vanadium-treated groups under the GFAP stain. Pyknotic index in CA1 pyramidal layer of untreated (18.82 ± 2.59) and 0.15mg/kg vanadium-treated groups (18.14 ± 5.92) were significantly higher than control (11.11 ± 0.93; p = 0.0205, p = 0.0373) while there was no significant difference in CA3 pyknotic index across all groups.ConclusionOur results suggest that vanadium has a dose-dependent protective effect on the pyramidal cells of the hippocampus and on memory and spatial learning functions in juvenile hydrocephalic mice.

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Section: Discussioncontrasting

confidence: 88%

Vanadium improves memory and spatial learning and protects the pyramidal cells of the hippocampus in juvenile hydrocephalic mice

Femi-Akinlosotu

Olopade²,

Obiako³

et al. 2023

Front. Neurol.

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“…Recently, the use of long-term endurance exercise to prime the molecular machinery for subsequent learning is increasingly recognized by scientists from basic research ( Berchtold et al, 2005 , 2010 ; Korol et al, 2013 ). In line with this, long-term exercise before learning is assumed to be a promising intervention strategy especially for motor rehabilitation ( Mang et al, 2013 ; Petzinger et al, 2013 ; Stoykov and Madhavan, 2015 ) suggesting a general positive transfer effect of endurance exercise on motor skill learning ( Kleim and Jones, 2008 ) that has already been proved empirically ( Quaney et al, 2009 ; Wang et al, 2015 ). However, there is a general lack of studies examining the effects of long-term exercise on motor learning and performance so that this area of research must be considered as largely underexplored to date ( Stoykov and Madhavan, 2015 ).…”

Section: Behavioral Evidencementioning

confidence: 82%

Endurance Exercise as an “Endogenous” Neuro-enhancement Strategy to Facilitate Motor Learning

Taubert

Villringer

Lehmann

2015

Front. Hum. Neurosci.

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Endurance exercise improves cardiovascular and musculoskeletal function and may also increase the information processing capacities of the brain. Animal and human research from the past decade demonstrated widespread exercise effects on brain structure and function at the systems-, cellular-, and molecular level of brain organization. These neurobiological mechanisms may explain the well-established positive influence of exercise on performance in various behavioral domains but also its contribution to improved skill learning and neuroplasticity. With respect to the latter, only few empirical and theoretical studies are available to date. The aim of this review is (i) to summarize the existing neurobiological and behavioral evidence arguing for endurance exercise-induced improvements in motor learning and (ii) to develop hypotheses about the mechanistic link between exercise and improved learning. We identify major knowledge gaps that need to be addressed by future research projects to advance our understanding of how exercise should be organized to optimize motor learning.

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“…A better preservation of cerebellar neurons is in line with the increased deposition of PNN in CN, and it is further strengthened by the incremented expression of BDNF in combination with reduction of deregulated autophagy. Yet, PNN and BDNF are also key regulators of neural plasticity (GomezPinilla et al, 2002;Foscarin et al, 2011;Wang et al, 2015). PNNs are accumulation of extracellular matrix molecules deposited after birth that stabilise synapse and restrict neural plasticity (Foscarin et al, 2011;Sale et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice

Fucà

Guglielmotto

Boda

et al. 2017

Neurobiology of Disease

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Authors' contributionEF and KL performed grafts; EF performed motor training, behavioral, immunohistochemical analyses and stereological counts; MG and EB performed molecular biology and biochemical experiments; EF, FR, KL and AB conceived experiments, EF, KL and AB interpreted data and wrote the manuscript; all the authors reviewed and approved the final manuscript. Highlights• Preventive grafts of Purkinje cells survive despite ongoing host neurodegeneration correlates. Our results demonstrate that, despite a good survival rate and integration of grafted PCs, the adopted grafting protocol could not alleviate the ataxic symptoms in tbl mice. Conversely, preventive motor training increases PCs survival with a moderate positive impact on the motor phenotype.

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Recovery of motor coordination after exercise is correlated to enhancement of brain-derived neurotrophic factor in lactational vanadium-exposed rats

Cited by 10 publications

References 28 publications

Vanadium improves memory and spatial learning and protects the pyramidal cells of the hippocampus in juvenile hydrocephalic mice

Vanadium improves memory and spatial learning and protects the pyramidal cells of the hippocampus in juvenile hydrocephalic mice

Endurance Exercise as an “Endogenous” Neuro-enhancement Strategy to Facilitate Motor Learning

Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice

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