Recovery of Glomerular and Tubular Function in Autotransplanted Dog Kidneys Preserved by Hypothermic Storage or Machine Perfusion

Gregg, Christine M.; Cos, Louis R.; Saraf, Pradeep G.; Fridd, C.W.; Linke, Charles A.

doi:10.1097/00007890-198611000-00002

Cited by 4 publications

(2 citation statements)

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“…Other studies on autotransplanted canine kidneys that underwent PP or CS for 24 to up to 96 h showed similar benefits of PP with regards to immediate graft function (25)(26)(27). A more recent study using autotransplanted porcine kidneys also found that PP porcine kidneys had significantly lower peak serum creatinine and blood urea in the 2 weeks following transplantation (28).…”

Section: Discussionmentioning

confidence: 77%

“…To evaluate kidney function following storage with PP or CS, Grundmann et al autotransplanted 72 canine kidneys following either PP or CS for 24-72 h. Using p-aminohippuric acid and inulin clearances as measures of immediate function, the authors found that immediate function of kidneys after 72 h of PP was significantly better than 24 h of CS (24). Other studies on autotransplanted canine kidneys that underwent PP or CS for 24 to up to 96 h showed similar benefits of PP with regards to immediate graft function (25)(26)(27). A more recent study using autotransplanted porcine kidneys also found that PP porcine kidneys had significantly lower peak serum creatinine and blood urea in the 2 weeks following transplantation (28).…”

Section: Figure 3: Overall Graft Survival Of Ecd Kidney Transplants Amentioning

confidence: 99%

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Pulsatile Perfusion Reduces the Incidence of Delayed Graft Function in Expanded Criteria Donor Kidney Transplantation

Matsuoka

Shah

Aswad

et al. 2006

American Journal of Transplantation

124

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The use of expanded criteria donors (ECD) has been proposed to help combat the discrepancy between organ availability and need. ECD kidneys are associated with delayed graft function (DGF) and worse long-term survival. The aim of this study is to evaluate the impact of pulsatile perfusion (PP) on DGF and graft survival in transplanted ECD kidneys. From January 2000 to December 2003, 4618 ECD kidney-alone transplants were reported to the United Network for Organ Sharing. PP was performed on 912 renal allografts. The prognostic factors of DGF were analyzed using multivariate logistic regression analysis. Risk factors for reduced allograft viability were greater in donors and recipients of PP kidneys. Three-year graft survival of ECD kidneys preserved with PP was similar to cold storage (CS) kidneys. The incidence of DGF in PP kidneys was significantly lower than CS kidneys (26% vs. 36%, p < 0.001). Despite having a greater number of risk factors for reduced graft viability, the ECD-PP kidneys had similar graft survival compared to ECD-CS kidneys. The use of PP, by decreasing the incidence of DGF, may possibly lead to lower overall costs and increased utilization of donor kidneys.

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Section: Discussionmentioning

confidence: 77%