Recovery of ethanol-induced <i>Akkermansia muciniphila</i> depletion ameliorates alcoholic liver disease

Grander, Christoph; Adolph, Timon E.; Wieser, Verena; Lowe, Patrick; Wrzosek, Laura; Gyöngyösi, Benedek; Ward, Doyle V.; Grabherr, Felix; Gerner, Romana R.; Pfister, A; Enrich, Barbara; Ciocan, Dragos; Macheiner, S; Mayr, Lisa; Drach, Matthias; Moser, Patrizia; Moschen, Alexander R.; Perlemuter, Gabriel; Szabó, Gyöngyi; Cassard-Doulcier, Anne-Marie; Tilg, Herbert

doi:10.1136/gutjnl-2016-313432

Cited by 452 publications

(392 citation statements)

References 57 publications

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“…The widespread nature of these microbial changes reflects the profound impact of alcohol despite the very skewed baseline of cirrhosis. While we specifically excluded patients with alcoholic hepatitis, prior studies have demonstrated a similar dysbiosis in their stool (Grander et al., ). We extend that data by defining changes in the mucosal microbial composition and come to an interesting conclusion that dysbiotic changes similar to that found with alcoholic hepatitis are already present in patients who are prone but have not developed it yet.…”

Section: Discussionmentioning

confidence: 99%

Continued Alcohol Misuse in Human Cirrhosis is Associated with an Impaired Gut–Liver Axis

Bajaj

Kakiyama

Zhao

et al. 2017

Alcoholism Clin & Exp Res

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Section: Discussionmentioning

confidence: 99%

Continued Alcohol Misuse in Human Cirrhosis is Associated with an Impaired Gut–Liver Axis

Bajaj

Kakiyama

Zhao

et al. 2017

Alcoholism Clin & Exp Res

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“…Collective findings have confirmed that the action of A. muciniphila could extend to various hepatic disorders such as fatty liver disease, hepatic inflammation, and hypercholesterolemia. Oral supplementation of A. muciniphila can restore A. muciniphila depletion caused by ethanol exposure in mice, preventing the liver from alcoholic injury, neutrophil infiltration, and steatosis (Grander et al, 2018). In a concanavalin A-induced liver injury mouse model, oral administration of A. muciniphila reduced serum Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) and alleviated liver damage (Wu et al, 2017).…”

Section: The Causative Role Of Akkermansia Muciniphila In Liver Disormentioning

confidence: 99%

“…A. muciniphila treatment restored epithelial tight junction proteins (claudin-3 and occludin) in colonic epithelial cells to defend against the invasion of ethanol. The evidence suggests that A. muciniphila has protective actions against alcoholic liver disease focusing on the intestine (Grander et al, 2018). Moreover, the interference of A. muciniphila in improving intestinal barrier function is evoked by improving occludin and Tjp-1 expressions and suppressing LPS production followed by increasing the variety and volume of gut microbes (Wu et al, 2017).…”

Section: The Causative Role Of Akkermansia Muciniphila In Liver Disormentioning

confidence: 99%

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

et al. 2020

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Obesity and its metabolic syndrome, including liver disorders and type 2 diabetes, are a worldwide epidemic and are intimately linked to diet. The gut microbiota interaction has been pointed to as a hot topic of research in the treatment of obesity and related metabolic diseases by influencing energy metabolism and the immune system. In terms of the novel beneficial microbes identified, Akkermansia muciniphila (A. muciniphila) colonizes the mucosa layer of the gut and modulates basal metabolism. A. muciniphila is consistently correlated with obesity. The causal beneficial impact of A. muciniphila treatment on obesity is coming to light, having been proved by a variety of animal models and human studies. A. muciniphila has been characterized as a beneficial player in body metabolism and has great prospects for treatments of the metabolic disorders associated with obesity, as well as being considered for next-generation therapeutic agents. This paper aimed to investigate the basic mechanism underlying the relation of A. muciniphila to obesity and its host interactions, as identified in recent discoveries, facilitating the establishment of the causal relationship in A. muciniphila-associated therapeutic supplement in humans.

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“…Although Akkermansia muciniphila were considered beneficial to mucin turnover [6], its overgrowth may also compromise the colonic integrity and enhance the enteric permeability. As results, gut microbes or their components such as lipopolysaccharide (LPS) can simply trespass the colonic barrier and enter the blood circulation to trigger immune activation and inflammatory responses.…”

Section: Introductionmentioning

confidence: 99%

Spring mineral water-borne bacteria reshape gut microbiota profiles and confer health benefits

Chen

Tan

Chen

et al. 2018

Preprint

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Background：Although dietary patterns are recognized to affect health by interfering with gut microbiota homeostasis, whether live or dead bacteria-bearing spring mineral water (MW) would also exert beneficial effects on health upon curing gut dysbiosis remains unknown. Results：Due to harboring live bacteria, the heated but unboiled MW from Bama, where centenarians are ubiquitously inhabited, reshapes the gut microbiota from a traveler-type to a local resident-type except for Prevotella. While chondroitin sulfate, a component occurring in livestock and poultry meats, increases the richness of sulfatase-secreting bacteria and sulfate-reducing bacteria, Bama MW dampens the overgrowth of those colonthinning bacteria and hampers the overexpression of multiple genes responsible for anti-inflammation, anti-oxidation, anti-hypoxia, anti-mutagenesis, and anti-tumorigenesis. Conclusions：Bama spring MW prevents the early-phase onset of breast cancer by curating gut dysbiosis. MW also compromises chromosomal DNA damage and ameliorate mitochondrial dysfunctions, implying it may extend lifespan.

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Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease

Abstract: Ethanol exposure diminishes intestinal abundance in both mice and humans and can be recovered in experimental ALD by oral supplementation. promotes intestinal barrier integrity and ameliorates experimental ALD. Our data suggest that patients with ALD might benefit from supplementation.

Cited by 452 publications

References 57 publications

Continued Alcohol Misuse in Human Cirrhosis is Associated with an Impaired Gut–Liver Axis

Continued Alcohol Misuse in Human Cirrhosis is Associated with an Impaired Gut–Liver Axis

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

Spring mineral water-borne bacteria reshape gut microbiota profiles and confer health benefits

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