Recovery of Erectile Function after Brief Aggressive Antihypertensive Therapy

Hale, Taben M.; Okabe, Hiroaki; Bushfield, Terri L; Heaton, Jeremy P.W.; Adams, Michael

doi:10.1016/s0022-5347(05)64919-1

Cited by 73 publications

(53 citation statements)

References 29 publications

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“…The ANS provides an environment that induces rat prostatic growth; the gland regresses in its absence. These findings were supported by additional animal studies using a strain of spontaneously hypertensive rats that developed increased autonomic activity, prostate hyperplasia, and ED [37][38][39]. Erectile function improved in this model after brief, aggressive treatment of the hypertension; this improvement may be related to improvement in structural vascular resistance within the penis and a decrease in responsiveness ofadrenoceptor-mediated erectolytic signaling.…”

Section: Autonomic Hyperactivitymentioning

confidence: 55%

The evolving relationship of erectile dysfunction and lower urinary tract symptoms

Köhler¹,

McVary

2008

Curr sex health rep

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Previously viewed as independent processes, erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) frequently co-associate and significantly influence the overall quality of life of men. Analysis of historical and emerging literature, using some of the Bradford Hill criteria, argues for a causal link between the two disease processes. Four mechanisms are proposed to explain the relationship between ED and LUTS. Understanding this relationship is crucial for several reasons: 1) additional information on risk factors for either disease could be important for patient screening; 2) the pool of affected men is increasing, given the age demographics in many societies; 3) sexual problems related to LUTS are not necessarily limited to ED; and 4) many medical or surgical treatments for one disorder affect the other.

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Section: Autonomic Hyperactivitymentioning

confidence: 55%

The evolving relationship of erectile dysfunction and lower urinary tract symptoms

Köhler¹,

McVary

2008

Curr sex health rep

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show abstract

“…The four theories interrelating ED and LUTS are decreased or altered nitric oxide synthase and nitric oxide levels in the prostate and penile smooth muscle; autonomic hyperactivity effects on LUTS, prostate growth, and ED; increased Rho-kinase activation and endothelin activity affecting the alternate pathways of smooth muscle relaxation and contraction; and prostate and penile atherosclerosis [8, [10][11][12][13][14][15][16][17]. With studies showing an association between BPH and ejaculatory dysfunction and theories outlining the biologic plausibility of this association, understanding the impact of treating one condition on the outcome of the other is important.…”

Section: Discussionmentioning

confidence: 99%

Alpha blockers and ejaculatory function: A state of the art review

Miller

Carson²

2007

Curr sex health rep

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Alpha-blocker therapy is commonly used in the treatment of the over 50% of men above the age of 50 with lower urinary tract symptoms associated with benign prostatic hyperplasia. With the use of -blockers comes the discussion of the potential effects these medications have on ejaculatory function. Whether -blockers affect ejaculatory function is not in question, but rather how does this occur, and can it be advantageous when treat-t t ing patients? This discussion reviews recently published data focusing on the association between lower urinary tract symptoms, benign prostatic hyperplasia, and sexual dysfunction; the etiology of ejaculatory dysfunction while taking -blockers; and the treatment of premature ejaculation with -blockers. The review outlines recent promising studies showing improvement of sexual dysfunction with -blocker treatment of BPH patients as well as studies showing successful treatment of premature ejaculation with -blocker therapy.

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“…Using a rat model, McVary et al [39] demonstrated that the ANS provides an environment that induces rat prostatic growth, whereas its absence leads to glandular regression. These fi ndings were supported by additional animal studies using spontaneously hypertensive rats (SHR) that developed increased autonomic activity, prostate hyperplasia, and ED [40,41]. Following brief but aggressive hypertension treatment, erectile function improved [41].…”

Section: Autonomic Hyperactivity and Metabolic Syndrome Effects On Lumentioning

confidence: 91%

“…These fi ndings were supported by additional animal studies using spontaneously hypertensive rats (SHR) that developed increased autonomic activity, prostate hyperplasia, and ED [40,41]. Following brief but aggressive hypertension treatment, erectile function improved [41]. These effects may be related to improvement in structurally based vascular resistance within the penis and the decrease in responsiveness of α 1 -adrenoceptor-mediated erectolytic signaling.…”

Section: Autonomic Hyperactivity and Metabolic Syndrome Effects On Lumentioning

confidence: 91%

Lower urinary tract symptoms, benign prostatic hyperplasia, and sexual dysfunction

Park¹,

Köhler²,

McVary

2008

Curr Bladder Dysfunct Rep

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Previously viewed as independent processes, sexual dysfunction (SD) and lower urinary tract symptoms (LUTS) frequently associate and signifi cantly detract from overall quality of life for men. Analysis of historic and emerging literature using some of the Bradford-Hill criteria argues causality between the two disease processes, with most data focusing on the interplay between LUTS and erectile dysfunction. Understanding of the relationship between SD and LUTS is crucial given the current societal age demographics leading to an increased pool of affected patients. Additional information on risk factors for either disease could potentially improve patient screening, and many currently available treatments (medical and surgical) for SD impact LUTS and vice versa.

show abstract

Recovery of Erectile Function after Brief Aggressive Antihypertensive Therapy

Cited by 73 publications

References 29 publications

The evolving relationship of erectile dysfunction and lower urinary tract symptoms

The evolving relationship of erectile dysfunction and lower urinary tract symptoms

Alpha blockers and ejaculatory function: A state of the art review

Lower urinary tract symptoms, benign prostatic hyperplasia, and sexual dysfunction

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