Recovery of crocins from saffron stigmas (Crocus sativus) in aqueous two-phase systems

Montalvo-Hernández, Bertha; Rito‐Palomares, Marco; Benavides, Jorge

doi:10.1016/j.chroma.2012.03.012

Cited by 60 publications

(64 citation statements)

References 51 publications

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“…A remaining work was devoted to the extraction of crocins (i.e., carotenoid derivatives) from Crocus sativus . 182 The ABS investigated ranged from polymer–polymer to polymer-salt, alcohol-salt, and IL-salt, the latter including [C 4 C 1 im][BF 4 ] and [C 2 C 1 im][C 1 CO 2 ]. During the optimization studies, the recoveries of crocins ranged from 38 to 66% for polymer–polymer, 72 to 100% for polymer-salt, 91 to 98% for alcohol-salt, and 74 to 97% for IL-salt ABS.…”

Section: Lipids and Other Hydrophobic Compoundsmentioning

confidence: 99%

Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends

et al. 2017

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Ionic liquids (ILs) have been proposed as promising media for the extraction and separation of bioactive compounds from the most diverse origins. This critical review offers a compilation on the main results achieved by the use of ionic-liquid-based processes in the extraction and separation/purification of a large range of bioactive compounds (including small organic extractable compounds from biomass, lipids, and other hydrophobic compounds, proteins, amino acids, nucleic acids, and pharmaceuticals). ILs have been studied as solvents, cosolvents, cosurfactants, electrolytes, and adjuvants, as well as used in the creation of IL-supported materials for separation purposes. The IL-based processes hitherto reported, such as IL-based solid–liquid extractions, IL-based liquid–liquid extractions, IL-modified materials, and IL-based crystallization approaches, are here reviewed and compared in terms of extraction and separation performance. The key accomplishments and future challenges to the field are discussed, with particular emphasis on the major lacunas found within the IL community dedicated to separation processes and by suggesting some steps to overcome the current limitations.

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Section: Lipids and Other Hydrophobic Compoundsmentioning

confidence: 99%

Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends

et al. 2017

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“…Moreover, they stated that the ATPE did not alter the composition these natural pigments and the antioxidant activity of the extract was relatively high as compared to conventional extraction techniques [126]. Other reported studies include the recovery of crocins [127] from Crocus sativas using an ethanol-potassium phosphate ATPS and the extraction of anthocyanins [128] from Brassica oleracea L.…”

Section: Applications Of Aqueous Two-phase System (Atps)mentioning

confidence: 99%

Aqueous two-phase system (ATPS): an overview and advances in its applications

et al. 2016

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Aqueous two-phase system (ATPS) is a liquid-liquid fractionation technique and has gained an interest because of great potential for the extraction, separation, purification and enrichment of proteins, membranes, viruses, enzymes, nucleic acids and other biomolecules both in industry and academia. Although, the partition behavior involved in the method is complex and difficult to predict. Current research shows that it has also been successfully used in the detection of veterinary drug residues in food, separation of precious metals, sewage treatment and a variety of other purposes. The ATPS is able to give high recovery yield and is easily to scale up. It is also very economic and environment friendly method. The aim of this review is to overview the basics of ATPS, optimization and its applications.

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“…The application of salting-out extraction for the bio-based chemicals has been recently reviewed in detail [2]. SOESs have also been used in the recovery of proteins [6,7], enzymes [4,8] and natural products [9][10][11]. However, even though a great amount of reports have been published on the separation of diverse target products with high partition coefficient and recovery on the laboratory scale, this technology has not been used in industrial scale, partially due to the limited engineering knowledge and understanding of this system.…”

Section: Introductionmentioning

confidence: 99%

“…However, even though a great amount of reports have been published on the separation of diverse target products with high partition coefficient and recovery on the laboratory scale, this technology has not been used in industrial scale, partially due to the limited engineering knowledge and understanding of this system. Almost all of the batch extraction experiments were conducted following an empirical procedure (centrifugation, settling overnight or achieve complete phase equilibrium) without considering the time of the phase separation process [5][6][7][8][10][11][12]. However, these data are necessary for industrial application because the rate of phase separation determines the equipment design and thus the operation costs.…”

Section: Introductionmentioning

confidence: 99%