Recovery of corneal sensitivity after laser-assisted subepithelial keratectomy

Wu, Ying; Chu, Ren-yuan; Zhou, Xing Tao; Dai, Jin Hui; Qu, Xiao M.; Rao, Srinivas; Lam, Dennis S C

doi:10.1016/j.jcrs.2006.01.066

Cited by 12 publications

(6 citation statements)

References 15 publications

(19 reference statements)

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“…No difference in the rate of recovery of corneal sensitivity or subbasal nerve morphology was observed in this study of LASIK and LASEK; however, Wu et al 39 and Lee et al 22 report that LASIK caused greater reduction in corneal sensitivity and subbasal nerve fiber density, respectively, than LASEK. This disagreement may be due to different surgical approaches.…”

Section: Subbasal Nervescontrasting

confidence: 66%

Subbasal nerve fiber regeneration after LASIK and LASEK assessed by noncontact esthesiometry and in vivo confocal microscopy: Prospective study

Darwish¹,

Brahma²,

O’Donnell³

et al. 2007

Journal of Cataract and Refractive Surgery

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Section: Subbasal Nervescontrasting

confidence: 66%

Subbasal nerve fiber regeneration after LASIK and LASEK assessed by noncontact esthesiometry and in vivo confocal microscopy: Prospective study

Darwish¹,

Brahma²,

O’Donnell³

et al. 2007

Journal of Cataract and Refractive Surgery

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“…The optic zone treated was also similar between groups: 6.99 ± 0.46 mm in CCN group and 7.16 ± 0.44 mm in SH group ( p > 0.05). 24 Furthermore, average keratometry was 7.49 ± 0.24 mm in CCN group, 7.46 ± 0.27 mm in SH group, and there was no statistically significant difference between groups ( p > 0.05).…”

Section: Methodsmentioning

confidence: 78%

Cationic nanoemulsion vs. 0.15% sodium hyaluronate artificial tears in the healing process following modern surface keratorefractive surgery

Jaworski

Cieślińska-Rypolc

Jadczyk-Sorek

et al. 2023

European Journal of Ophthalmology

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Purpose The aim of this study was to investigate the influence of artificial tears containing either cationic nanoemulsion (CCN) or sodium hyaluronate artificial tears (SH) on early postoperative healing after modern surface refractive surgery. Materials and Methods In this multicenter, prospective, double-masked, parallel-group (1:1), comparative study, 129 patients (n = 255 eyes) were randomized to receive CCN (n = 128) or SH (n = 127) as an adjuvant treatment after either transepithelial photorefractive keratectomy (transPRK) or Epi-Bowman keratectomy (EBK). The patients’ perspectives were gathered using the Ocular Surface Disease Index (OSDI) questionnaire, and uncorrected (UCVA), and corrected (BCVA) visual acuity were assessed before and one week and one month after the procedure. In addition, corneal epithelization and subjective assessment of visual blur and eye irritation on drop instillation were assessed at one week postoperatively. Results No statistically significant differences were found between two groups in age, spherical equivalent refractive error, UCVA, BCVA or OSDI scores before the procedure. There was also no difference between groups in UCVA one week and one month after the procedure. However, statistically significantly lower OSDI scores were found one week and one month after the procedure in the CCN group. Moreover, blurred vision after use of the eye drops was observed less frequently in the CCN group than in the SH group. Conclusions The CCN and SH groups had similar postoperative UCVA. However the significantly lower OSDI scores and less frequently blurred vision after application of the eye drops in the CCN group suggest better subjective outcomes in this group.

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“…Some studies have rejected the relationship regarding the effect of ablation depth or amount of myopia refractive error before surgery on the recovery of corneal sensation in LASEK [12] . In contrast, some have reported the existence of this relation significantly [14] . Also, concerning similar studies on other types of refractive surgeries, various results have been mentioned in this field.…”

Section: Discussionmentioning

confidence: 87%

“…Few studies are available regarding the recovery of corneal sensation after the LASEK, and the results have been somewhat contradictory. For example, Hermann et al [12] reported this duration as 1mo, while Wu et al [14] and Horwath-Winter et al [15] reported it as 3mo. Although refractive surgeries damage corneal nerve fibers, understanding the effects of these surgeries on corneal sensitivity and its recovery time is crucial.…”

Section: Introductionmentioning

confidence: 99%

How long does the recovery of corneal sensitivity in different corneal regions take after LASEK?

Mirzajani,

Khezri,

Jafarzadehpur

et al. 2023

Int J Ophthalmol

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AIM: To determine the corneal sensitivity recovery period after laser-assisted sub-epithelial keratectomy (LASEK) refractive surgery and investigate the effects of ablation depth on it. METHODS: In this study examinations were performed on 90 right eyes of 90 people (34 males and 56 females) with an age range of 20-35 and an average of 22.26±3.8 years old. A sensation of 5 corneal regions, including the center and 4 mid-peripheral regions, i.e., nasal, inferior, temporal, and superior, each at a distance of 2 mm from the center of the cornea were measured with a Cochet-Bonnet esthesiometer device in 3-time points including before LASEK, 1 and 3mo after the surgery, respectively. LASEK was performed on individuals with stabilized myopia of -1.00 to -7.00 diopters and astigmatism of less than 2.00 diopters. Furthermore, the individuals were divided into three groups regarding ablation depth. RESULTS: The highest level of corneal sensitivity before surgery was related to the center of the cornea (59.1±7.76), and the highest level of corneal sensitivity loss was also related to this region. The sensation of all measured corneal regions significantly reduced 1mo postoperatively and returned to their preoperative levels 3mo after surgery (mean of 5 corneal regions in levels of preoperation: 58.2±6.48, 1mo postoperation: 57.3±5.84, 3mo postoperation: 58.2±5.49; P<0.05). A significant relationship was found between ablation depth and corneal sensitivity changes in the center and temporal regions (P<0.05). CONCLUSION: Corneal sensitivity in myopia and low astigmatism decreases after LASEK and reaches the preoperative level within 3mo. The depth of ablation during surgery affected the recovery of corneal sensitivity.

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Recovery of corneal sensitivity after laser-assisted subepithelial keratectomy

Abstract: Recovery of corneal sensitivity began 1 month after LASEK and was completed by 3 months in eyes treated for low-moderate myopia and at 6 months in eyes with high myopia. The depth of ablation during surgery affected the recovery of corneal sensitivity.

Cited by 12 publications

References 15 publications

Subbasal nerve fiber regeneration after LASIK and LASEK assessed by noncontact esthesiometry and in vivo confocal microscopy: Prospective study

Subbasal nerve fiber regeneration after LASIK and LASEK assessed by noncontact esthesiometry and in vivo confocal microscopy: Prospective study

Cationic nanoemulsion vs. 0.15% sodium hyaluronate artificial tears in the healing process following modern surface keratorefractive surgery

How long does the recovery of corneal sensitivity in different corneal regions take after LASEK?

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