Recovery of brain from deficiency of essential fatty acids in rats

Odutuga, A.A.

doi:10.1016/0005-2760(77)90038-8

Cited by 23 publications

(25 citation statements)

References 26 publications

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“…data). Due to the key role of brain in the regulation of physiological functions, its chemical composition is relatively constant and more resistant to the influence of external factors than other organs (Odutuga 1977). Therefore, modifications found in the brain highlight the importance of this dietary change, proving that the presence of aquafeed in the diet occurs regularly, and the magnitude of this change opens the question as to what may be the extent of the effect on fish health and performance.…”

Section: Fa Profiles Of Adult Fishmentioning

confidence: 99%

Monitoring the influence of marine aquaculture on wild fish communities: benefits and limitations of fatty acid profiles

Fernandez‐Jover¹,

Arechavala-López²,

Martínez-Rubio³

et al. 2011

Aquacult. Environ. Interact.

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Fatty acids (FA) have been applied as indicators of the influence of coastal sea-cage fish farming on wild fish communities in several recent scientific publications. Due to the relatively high conservation of FA composition throughout the food web, they are useful for characterizing trophic relationships. The increasing utilization of vegetable or alternative animal oils in the production of aquafeeds results in cultivated fish exhibiting higher levels of terrestrial FAs in their tissues. As previously reported, wild fish ubiquitously aggregate around fish farms as a consequence of the introduction of new habitat and the easy availability of food—fish farms act as enhanced fish aggregation devices (FADs). The influence of food pellets on the composition of wild fish has been detected in recent studies on salmon, sea bass and sea bream aquaculture, with increased levels of linoleic acid (18:2n-6) and a low n-3/n-6 ratio as clear indicators of the consumption of food pellets from the farms. The potential ecological and physiological effects on wild fish are presently unknown. In the present article, guidelines are proposed for the investigation and use of terrestrial FAs to track the effects of coastal aquaculture on wild fish communities and local fisheries, as well as the benefits or limitations of this technique

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Section: Fa Profiles Of Adult Fishmentioning

confidence: 99%

Monitoring the influence of marine aquaculture on wild fish communities: benefits and limitations of fatty acid profiles

Fernandez‐Jover¹,

Arechavala-López²,

Martínez-Rubio³

et al. 2011

Aquacult. Environ. Interact.

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show abstract

“…Sphingomyelin, another myelin lipid, was significantly reduced to 69.4 and 68.4% (p<0.001) in cerebrum and cerebellum respectively when rats were maintained on riboflavin-deficient diet. Such a reduction has been previously reported for essential fatty acid deficiency (5).…”

Section: Resultsmentioning

confidence: 66%

“…The present study has clearly shown that there are interesting similarities between the pathology of essential fatty acid deficiency (5,15) and riboflavin deficiency, particularly as regards brain composition. Foy and Mbaya (1) have suggested that the enormous increase in the size of liver mitochondria in riboflavin-deficient mice maybe associated with diminished mitochondrial function.…”

Section: Resultsmentioning

confidence: 78%

The effect of riboflavin deficiency on cerebrum and cerebellum of developing rat brain.

Ogunleye

Odutuga

1989

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryAfter 21-day-old weanling rats were maintained on diets deficient in riboflavin the weights of their brains were 19.8% less than those of rats on control diets. In riboflavin deficiency, the myelin lipids, cerebrosides, and sphingomyelin, as well as phosphatidylethanolamine, a significant component of the myelin membrane, were considerably reduced in proportion.It is considered that riboflavin plays some role in the metabolism of essential fatty acids in brain lipids and the pathological effect of its deficiency is similar to that of essential fatty acid deficiency, causing a fast impairment to brain development and maturation.

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“…The reduction in Na + K + ATPase activity observed in the present investigation, therefore is considered to be a result of the ingestion of peroxidized mustard oil affecting the phospholipids matrix and changing the structure and function of brain or kidney cells and membranes (Odutuga, 1977) and probably impairing the proper coupling of oxidative phosphorylation.…”

Section: Namentioning

confidence: 66%

“…The substanitial red shift in electronic absorption (peak at 238nm) exhibited by the heated oil samples would indicate the presence of a conjugated double bond band (also known as k band) in the fatty acid molecule (Lamba et al, 1991) Incorporation of this altered fatty acid molecule into membrane phospholipids may likely lead to loss of essentially of the phospholipids and affect lipid membrane structure and function relationship in biological systems (Odutuga, 1977;Odutuga et al, 1997). …”

Section: Namentioning

confidence: 99%

Deterioration in Thermally Oxidized Mustard Oil: A Spectroscopic Investigation and Toxicological Impact on Selected Rat Tissues

Singh¹,

Verma²,

Bissa³

2013

Orientjchem.

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Recovery of brain from deficiency of essential fatty acids in rats

Cited by 23 publications

References 26 publications

Monitoring the influence of marine aquaculture on wild fish communities: benefits and limitations of fatty acid profiles

Monitoring the influence of marine aquaculture on wild fish communities: benefits and limitations of fatty acid profiles

The effect of riboflavin deficiency on cerebrum and cerebellum of developing rat brain.

Deterioration in Thermally Oxidized Mustard Oil: A Spectroscopic Investigation and Toxicological Impact on Selected Rat Tissues

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