Recovery from slow inactivation of Shab K<sup>+</sup>channels

Arias‐Olguín, Imilla I.; Carrillo, Elisa; Islas, León D; Gómez-Lagunas, Froylán

doi:10.4161/chan.24585

Cited by 2 publications

(1 citation statement)

References 14 publications

(24 reference statements)

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“…medium of neurons upon firing action potentials, produce the well-known acceleration of recovery from ball-and-chain inactivation, and slow down the entry into C-type inactivation ( [17] and references therein cited). Shab presents a non-C type slow inactivation, increases of external K + accelerate the entry [43] and slow down the recovery from slow inactivation [48]. These examples show that increases in external [K + ] dynamically change the amount of K + channels available to repolarize the cells.…”

Section: Physiological Consequences Of the K + -Dependent Stability Of K + Channelsmentioning

confidence: 95%

Conductance stability and Na+ interaction with Shab K+ channels under low K+ conditions

2021

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Section: Physiological Consequences Of the K + -Dependent Stability Of K + Channelsmentioning

confidence: 95%

Conductance stability and Na+ interaction with Shab K+ channels under low K+ conditions

2021

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Dynamical characterization of inactivation path in voltage-gated Na⁺ion channel by non-equilibrium response spectroscopy

Pal

Gangopadhyay

2016

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Inactivation path of voltage gated sodium channel has been studied here under various voltage protocols as it is the main governing factor for the periodic occurrence and shape of the action potential. These voltage protocols actually serve as non-equilibrium response spectroscopic tools to study the ion channel in non-equilibrium environment. In contrast to a lot of effort in finding the crystal structure based molecular mechanism of closed-state(CSI) and open-state inactivation(OSI); here our approach is to understand the dynamical characterization of inactivation. The kinetic flux as well as energetic contribution of the closed and open- state inactivation path is compared here for voltage protocols, namely constant, pulsed and oscillating. The non-equilibrium thermodynamic quantities used in response to these voltage protocols serve as improved characterization tools for theoretical understanding which not only agrees with the previously known kinetic measurements but also predict the energetically optimum processes to sustain the auto-regulatory mechanism of action potential and the consequent inactivation steps needed. The time dependent voltage pattern governs the population of the conformational states which when couple with characteristic rate parameters, the CSI and OSI selectivity arise dynamically to control the inactivation path. Using constant, pulsed and continuous oscillating voltage protocols we have shown that during depolarization the OSI path is more favored path of inactivation however, in the hyper-polarized situation the CSI is favored. It is also shown that the re-factorisation of inactivated sodium channel to resting state occurs via CSI path. Here we have shown how the subtle energetic and entropic cost due to the change in the depolarization magnitude determines the optimum path of inactivation. It is shown that an efficient CSI and OSI dynamical profile in principle can characterize the open-state drug blocking phenomena.

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Recovery from slow inactivation of Shab K⁺channels

Abstract: Regarding the latter, we also show that external K + and TEA slow down recovery from inactivation in agreement with the hypothesis that the mechanism of Shab inactivation qualitatively differs from C-type inactivation.

Cited by 2 publications

References 14 publications

Conductance stability and Na+ interaction with Shab K+ channels under low K+ conditions

Conductance stability and Na+ interaction with Shab K+ channels under low K+ conditions

Dynamical characterization of inactivation path in voltage-gated Na⁺ion channel by non-equilibrium response spectroscopy

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Recovery from slow inactivation of Shab K+channels

Abstract: Regarding the latter, we also show that external K + and TEA slow down recovery from inactivation in agreement with the hypothesis that the mechanism of Shab inactivation qualitatively differs from C-type inactivation.

Cited by 2 publications

References 14 publications

Conductance stability and Na+ interaction with Shab K+ channels under low K+ conditions

Conductance stability and Na+ interaction with Shab K+ channels under low K+ conditions

Dynamical characterization of inactivation path in voltage-gated Na+ion channel by non-equilibrium response spectroscopy

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Recovery from slow inactivation of Shab K⁺channels

Dynamical characterization of inactivation path in voltage-gated Na⁺ion channel by non-equilibrium response spectroscopy