2012
DOI: 10.3109/17435390.2011.648223
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Recovery from silver-nanoparticle-exposure-induced lung inflammation and lung function changes in Sprague Dawley rats

Abstract: In a previous study, the lung function, as indicated by the tidal volume, minute volume, and peak inspiration flow, decreased during 90 days of exposure to silver nanoparticles and was accompanied by inflammatory lesions in the lung morphology. Therefore, this study investigated the recovery from such lung function changes in rats following the cessation of 12 weeks of nanoparticle exposure. Male and female rats were exposed to silver nanoparticles (14-15 nm diameter) at concentrations of 0.66 × 10(6) particle… Show more

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Cited by 100 publications
(187 citation statements)
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“…However, it should be noted that the presence of silver in bone marrow was not determined in the study and data for intravenous injection show clear genotoxic effects of silver NPs (Dobrzynska et al, 2014). A study investigating the reversibility of lung function showed impairment after 12 weeks of exposure employed silver NPs with concentrations of 6.6 Â 10 5 to 3.2 Â 10 6 particles/cm 3 (Song et al, 2013). At the highest dose, some lung inflammation was detected even after 12 weeks of follow-up indicating possible chronic damage.…”
Section: Discussionmentioning
confidence: 92%
“…However, it should be noted that the presence of silver in bone marrow was not determined in the study and data for intravenous injection show clear genotoxic effects of silver NPs (Dobrzynska et al, 2014). A study investigating the reversibility of lung function showed impairment after 12 weeks of exposure employed silver NPs with concentrations of 6.6 Â 10 5 to 3.2 Â 10 6 particles/cm 3 (Song et al, 2013). At the highest dose, some lung inflammation was detected even after 12 weeks of follow-up indicating possible chronic damage.…”
Section: Discussionmentioning
confidence: 92%
“…Using the MFC for the first dilutor (27.19±0.05 L/min, mean±SE), a portion of the high-nanoparticle-concentration was then diverted to the medium-concentration chamber. Similarly, a portion of the medium-nanoparticle-concentration was then diverted to the low-concentration chamber using a second MFC (2.33 ± 0.01 L/min) [16].…”
Section: Generation Of Silver Nanoparticlesmentioning
confidence: 99%
“…Such an increasingly widespread usage of AgNPs leads to the exposure of humans, animals and plants through industrial or domestic waste which could produce harmful biological response [11]. The target organs for silver nanoparticles have been shown to be the liver in a 28-day oral toxicity study [12][13] and 90-day oral subchronic study [14], and the liver and lungs in 90-day inhalation studies [15][16]. It was reported that AgNPs induced reactive oxygen species (ROS) production, cytotoxicity, pro-inflammatory effect, DNA damage, cell cycle disturb, necrosis and apoptosis in various in vitro test [17][18][19][20].…”
Section: Introductionmentioning
confidence: 99%
“…Unfortunately, silver levels in these organs were not reported. As the NOAELs of 100 µg/m 3 and 117 µg/m 3 (based on liver and lung toxicity) in subchronic inhalation toxicity studies are significantly higher (Sung et al 2009;Song et al 2013), an absence of effects in the male reproductive organs at 60 µg/m 3 in the study by Ji et al (2007) would, however, not be sufficient to exclude those as possible targets of silver toxicity.…”
Section: In Vivo Reproductive and Developmental Toxicitymentioning
confidence: 96%