Recovery from mild traumatic brain injury

Stulemeijer, Maja; Werf, Sieberen van der; Bleijenberg, Gijs; Biert, J.; Brauer, Jolanda; Vos, Pieter E.

doi:10.1007/s00415-006-0156-5

Cited by 128 publications

(87 citation statements)

References 27 publications

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“…Fatigue is a common and persistent problem in PCSS (Stulemeijer et al, 2006;Ziino & Ponsford, 2006), and it too has its own set of neurochemical, neuroimaging, and neuropsychological differences (de Lange et al, 2004;Kozora et al, 2006). The same can be said about the co-occurrence of PTSD in those involved in accidental injury or assault as the source of their concussion (Bryant, 2001;Creamer et al, 2005;McCauley et al, 2001) and the role of stress hormones in the behavioral response to injury (Sojka et al, 2006).…”

Section: Confounding Factors That Must Be Considered In the Design Ofmentioning

confidence: 99%

Neuropsychology and clinical neuroscience of persistent post-concussive syndrome

Bigler

2007

J Int Neuropsychol Soc

359

248

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On the mild end of the acquired brain injury spectrum, the terms concussion and mild traumatic brain injury (mTBI) have been used interchangeably, where persistent post-concussive syndrome (PPCS) has been a label given when symptoms persist for more than three months post-concussion. Whereas a brief history of concussion research is overviewed, the focus of this review is on the current status of PPCS as a clinical entity from the perspective of recent advances in the biomechanical modeling of concussion in human and animal studies, particularly directed at a better understanding of the neuropathology associated with concussion. These studies implicate common regions of injury, including the upper brainstem, base of the frontal lobe, hypothalamic-pituitary axis, medial temporal lobe, fornix, and corpus callosum. Limitations of current neuropsychological techniques for the clinical assessment of memory and executive function are explored and recommendations for improved research designs offered, that may enhance the study of long-term neuropsychological sequelae of concussion. (JINS, 2008, 14, 1-22.)

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Section: Confounding Factors That Must Be Considered In the Design Ofmentioning

confidence: 99%

Neuropsychology and clinical neuroscience of persistent post-concussive syndrome

Bigler

2007

J Int Neuropsychol Soc

359

248

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“…Most neuropsychologic symptoms of mild TBI generally clear completely within the first 3 mo (1). Among these symptoms, fatigue is one of the most frequently reported, accounting for almost one third of a large group of mild-TBI patients 6 mo after injury, and is associated with limitations in daily functioning (18). In the present study, mild-TBI patients were recruited from a population that presented with cognitive fatigue as a prominent contributor to their inability to return to normal work despite relatively normal neuropsychologic test results.…”

Section: Discussionmentioning

confidence: 99%

Differential SPECT Activation Patterns Associated with PASAT Performance May Indicate Frontocerebellar Functional Dissociation in Chronic Mild Traumatic Brain Injury

et al. 2009

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Patients with mild traumatic brain injury (TBI) often complain of cognitive fatigue during the chronic recovery phase. The Paced Auditory Serial Addition Test (PASAT) is a complex psychologic measure that may demonstrate subtle deficiencies in higher cognitive functions. The purpose of this study was to investigate the brain activation of regional cerebral blood flow (rCBF) with PASAT in patients with mild TBI to explore mechanisms for the cognitive fatigue. Methods: Two groups consisting of 15 patients with mild TBI and 15 healthy control subjects underwent 99m Tc-ethylene cysteine dimer SPECT at rest and during PASAT on a separate day. Cortical rCBF was extracted using a 3-dimensional stereotactic surface projection and statistically analyzed to identify areas of activation, which were compared with PASAT performance scores. Results: Image analysis demonstrated a difference in the pattern of activation between patients with mild TBI and healthy control subjects. Healthy control subjects activated the superior temporal cortex (Brodmann area [BA] 22) bilaterally, the precentral gyrus (BA 9) on the left, and the precentral gyrus (BA 6) and cerebellum bilaterally. Patients with mild TBI demonstrated a larger area of supratentorial activation (BAs 9, 10, 13, and 46) but a smaller area of activation in the cerebellum, indicating frontocerebellar dissociation. Conclusion: Patients with mild TBI and cognitive fatigue demonstrated a different pattern of activation during PASAT. Frontocerebellar dissociation may explain cognitive impairment and cognitive fatigue in the chronic recovery phase of mild traumatic brain injury.

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“…Indeed, fatigue assessed by validated scales is quite common. In a cohort of mild TBI patients, a 3rd still suffered from fatigue 6 months after the traumatic event, which affected negatively their life quality (8). It should be remembered that estimates of frequency, severity, and timing of those symptoms are influenced by issues such as compensation claims, changes in daily habits and occupational status of the patients following the traumatic event.…”

Section: The Clinical Features Of Disturbed Sleep In Tbimentioning

confidence: 99%

Sleep and Sleep Impairment in Victims of Traumatic Brain Injury

Gadoth

2018

Middle East J Rehabil Health Stud

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Context: Sleep impairment after Traumatic Brain Injury (TBI) is a common consequence of the injury and frequently complicates recovery. To review in brief the current knowledge in regard to sleep impairment following traumatic brain injury. Evidence Acquisition: The relevant literature was reviewed. Results: Practical issues in regard to epidemiology, clinical presentation, medical workup, as well as pathophysiology and treatment modes were addressed. Conclusion: As the spectrum of civil head and brain trauma is quickly expanding, it is important to increase our knowledge of sleep impairment characteristics in victims of TBI and look for more efficient treatment modes for those impairments than those used today.

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Recovery from mild traumatic brain injury

Cited by 128 publications

References 27 publications

Neuropsychology and clinical neuroscience of persistent post-concussive syndrome

Neuropsychology and clinical neuroscience of persistent post-concussive syndrome

Differential SPECT Activation Patterns Associated with PASAT Performance May Indicate Frontocerebellar Functional Dissociation in Chronic Mild Traumatic Brain Injury

Sleep and Sleep Impairment in Victims of Traumatic Brain Injury

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