Recovery From Infants With Respiratory Illness of a Virus Related to Chimpanzee Coryza Agent (Cca)

Chanock, Robert M.; Roizman, Bernard; Myers, Robert Manson

doi:10.1093/oxfordjournals.aje.a119901

Cited by 316 publications

(272 citation statements)

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“…9,10 The illness quickly spread from sick chimpanzees to other monkeys, indicating the presence of a highly contagious pathogen that was originally denominated the chimpanzee coryza agent. 10 In 1957, Chanock and Finberg isolated a similar agent from throat swab samples of infants with a severe respiratory disease, 11,12 which was found to be identical to the one reported by Blount et al in chimpanzees. 10 The isolated pathogen induced syncytia formation, via the virus fusion protein (F) on permissive cell types in cultures.…”

Section: Introductionmentioning

confidence: 67%

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Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection

et al. 2016

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Human Respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are the two major etiological viral agents of lower respiratory tract diseases, affecting mainly infants, young children and the elderly. Although the infection of both viruses trigger an antiviral immune response that mediate viral clearance and disease resolution in immunocompetent individuals, the promotion of long-term immunity appears to be deficient and reinfection are common throughout life. A possible explanation for this phenomenon is that hRSV and hMPV, can induce aberrant T cell responses, which leads to exacerbated lung inflammation and poor T and B cell memory immunity. The modulation of immune response exerted by both viruses include different strategies such as, impairment of immunological synapse mediated by viral proteins or soluble factors, and the induction of pro-inflammatory cytokines by epithelial cells, among others. All these viral strategies contribute to the alteration of the adaptive immunity in order to increase the susceptibility to reinfections.In this review, we discuss current research related to the mechanisms underlying the impairment of T and B cell immune responses induced by hRSV and hMPV infection. In addition, we described the role each virulence factor involved in immune modulation caused by these viruses.

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Section: Introductionmentioning

confidence: 67%

“…10 The isolated pathogen induced syncytia formation, via the virus fusion protein (F) on permissive cell types in cultures. 12,13 Therefore, this pathogen was renamed as a hRSV.…”

Section: Introductionmentioning

confidence: 99%

Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection

et al. 2016

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“…a- Barreno et al, 1990 ;Rueda et al, 1991Rueda et al, , 1994Rueda et al, , 1995. However, the Long strain is the oldest isolate of HRSV (Chanock et al, 1957). It has been passed in tissue culture cells for long periods of time and is distantly related to viruses isolated during recent epidemics .…”

Section: Introductionmentioning

confidence: 99%

Antigenic structure of the human respiratory syncytial virus G glycoprotein and relevance of hypermutation events for the generation of antigenic variants.

Martı́nez

Dopazo

Melero

1997

Journal of General Virology

133

156

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A set of monoclonal antibodies (MAbs) specific for the attachment (G) glycoprotein of a recently isolated strain of human respiratory syncytial virus (HRSV) is described. Antibody reactivity with a series of HRSV isolates belonging to antigenic groups A and B identified three epitope categories : (i) strainspecific or variable epitopes that were present in a limited set of viruses from the same antigenic group, (ii) group-specific epitopes shared by viruses from the same antigenic group and (iii) conserved epitopes present in all HRSV isolates. Sequence analysis of escape mutants was used to map relevant antigenic sites of the G glycoprotein. Strain-specific epitopes were located preferentially in the variable C-terminal third of the G polypeptide, in agreement with previous studies of the Long strain. However, a

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“…Shortly after, the same virus was isolated from respiratory secretions of infants and young children with bronchiolitis and pneumonia [2,3]. It was suggested that CAA was a virus of human origin, which could have been transmitted by the laboratory personnel in charge of handling the chimpanzees.…”

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confidence: 99%

Intranasal treatment with a novel immunomodulator mediates innate immune protection against lethal pneumonia virus of mice

et al. 2016

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Respiratory syncytial virus (RSV) is the major causative agent of acute lower respiratory tract infections in infants and young children. Unfortunately, there are no licensed RSV vaccines available, and the few treatment options for high-risk individuals are either extremely costly or cause severe side effects and toxicity. Thus, the development of effective vaccines and therapeutic interventions against RSV is a preeminent public health priority.

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Recovery From Infants With Respiratory Illness of a Virus Related to Chimpanzee Coryza Agent (Cca)

Cited by 316 publications

References 9 publications

Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection

Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection

Antigenic structure of the human respiratory syncytial virus G glycoprotein and relevance of hypermutation events for the generation of antigenic variants.

Intranasal treatment with a novel immunomodulator mediates innate immune protection against lethal pneumonia virus of mice

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