Recovery from dietary iron deficiency anaemia in rats by the intake of microencapsulated ferric saccharate

Abstract

This study examined the bioavailability of iron contained in microencapsulated ferric saccharate in a rat model of iron deficiency anaemia. Three groups of male Sprague-Dawley rats with induced iron deficiency anaemia were subsequently treated with a control Fe-deficient diet (2-6 mg Fe/Kg of diet) with or without the addition of 10 mg Fe/Kg of diet (in form of ferrous sulphate or microencapsulated ferric saccharate) for 2 weeks. The bioavailability of microencapsulated ferric saccharate was examined by measuring body weight gain, feed efficiency and reticulocyte parameters, and compared with the bioavailability of ferrous sulphate. Final body weight, feed efficiency, mean corpuscular volume of reticulocytes and average haemoglobin content in reticulocytes were significantly higher in anaemic rats supplemented with either microencapsulated ferric saccharate or ferrous sulphate, compared to anaemic controls. No significant differences were found between the two iron-supplemented groups. The total number of reticulocytes showed a similar trend. The results demonstrated that ingestion of microencapsulated ferric saccharate is as effective as ferrous sulphate in recovery from iron deficiency anaemia.

Antioxidant and Lipid-Lowering Effects of Buriti Oil (Mauritia flexuosa L.) Administered to Iron-Overloaded Rats

“…Regarding dietary intake, the SFe group consumed less diet than the other groups, probably due to the ferrous sulfate taste interference on the rat gustatory sensitivity to the standard diet [ 36 ]. Although the BFe rats were also treated with FeSO 4 , no decrease in food consumption was observed, which may indicate that the buriti oil presence in the diet promoted a palatable effect [ 37 ].…”

Tolerability of Oral Supplementation with Microencapsulated Ferric Saccharate Compared to Ferrous Sulphate in Healthy Premenopausal Woman: A Crossover, Randomized, Double-Blind Clinical Trial

“…Previous studies on the MFS formulation have shown the bioavailability of this compound to be similar to that of the FS preparation, in both experimental and human studies, which supports the background evidence for the design of the present trial. In an experiment with male Sprague–Dawley rats, the animals with iron deficiency anemia were treated with an iron-deficient diet for 14 days with or without the addition of iron in the form of FS or MFS [ 34 ]. No differences were observed between the two fortified groups in body weight, feed efficiency, mean corpuscular volume of reticulocytes, and average hemoglobin content in the reticulocytes, with significant differences compared to the negative control group.…”

“…No differences were observed between the two fortified groups in body weight, feed efficiency, mean corpuscular volume of reticulocytes, and average hemoglobin content in the reticulocytes, with significant differences compared to the negative control group. Overall, this study showed that MFS displayed a similar bioavailability to that of FS at the dose tested; so, the ingestion of MFS is as effective as that of FS in the recovery from iron deficiency anemia in this model [ 34 ]. Similar findings were observed in a crossover, randomized, double-blind study, comparing the absorption of iron from MFS and FS in a fortified milk product in 17 healthy subjects [ 35 ].…”

Ameliorative iron-deficiency anemia levels using natural orange juice and fortified with different concentrations of mango, strawberries and beetroot juices in male albino rats

“…Longer periods of iron deficiency caused low iron storage, decreased hemoglobin biosynthesis and giving rise to anemia [30]. Microencapsulated ferric saccharate or ferrous sulphate induced high significant of final body weight, feed efficiency, mean corpuscular volume of reticulocytes and average haemoglobin content in reticulocytes for anaemic rats supplemented with either compared to anaemic controls [31]. Fruits are considered healthy foods because; contain a large amount of antioxidants such as, vitamins, dietary fiber and minerals.…”