Recovery from amnesia induced by pre-test injections of monoamine oxidase inhibitors

Botwinick, Chaim Y.; Quartermain, David

doi:10.1016/0091-3057(74)90083-5

Cited by 55 publications

(17 citation statements)

References 24 publications

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“…For example, MAO inhibitors enhance memory and attenuate age, neuropathologically, and experimentally induced amnesia (Roberts et al 1970;Botwinick and Quartermain 1974;Knoll et al 1977;Timar et al 1979;Finali et al 1991;Stoll et al 1994;Yavich et al 1996). Typically, activation of the dopaminergic, noradrenergic, or serotoninergic systems enhances memory, whereas inhibition of these systems produces memory deficits (Decker and McGaugh 1991;McNamara and Skelton 1993;Izquierdo and Medina 1995;Harvey 1996;Buhot 1997;White 1997).…”

Section: Introductionmentioning

confidence: 99%

Task-dependent effects of the antidepressant/antipanic drug phenelzine on memory

1999

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Phenelzine (PLZ) is a non-selective monoamine oxidase (MAO) inhibitor commonly used to treat depression and panic disorder. In addition to increasing levels of biogenic amines in the brain, PLZ elevates brain levels of the amino acid gamma-aminobutyric acid (GABA; Baker et al. 1991; present study). Given the extensive evidence implicating biogenic amines and GABA in mnemonic processes, PLZ may affect learning and memory. To investigate this possibility, male Sprague-Dawley rats were given PLZ sulfate (15 or 30 mg/kg, based on free base weight) 2 h prior to training in a continuous multiple trial inhibitory avoidance (CMIA) and spatial water maze task. Retention was assessed 48 h later. The results indicated that PLZ enhanced CMIA and impaired water maze retention performance. Compared to control rats, rats given PLZ took significantly longer to re-enter the shock compartment and swam longer distances before reaching the escape platform on the retention tests. These effects of PLZ did not appear to be the result of PLZ-induced changes in acquisition or retrieval processes, activity levels, or footshock sensitivity. Combined, these findings indicate that PLZ influences memory in a task-dependent manner. These differential effects of PLZ may be the result of contrasting influences of GABA and biogenic amines on memory.

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Section: Introductionmentioning

confidence: 99%

Task-dependent effects of the antidepressant/antipanic drug phenelzine on memory

1999

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“…Drugs or brain stimulation procedures that increase or decrease neural arousal have a corresponding effect on strength of retention. Moreover, the impairment in this case is reversible (Botwinick & Quartermain, 1974), a result implicating disruption of retrieval as the source of amnesia. The same pattern holds for norepinephrine (Gold & van Buskirk, 1975) and for stimulation of the reticular formation (Bloch, 1976), and the same pattern holds for drugs that deplete norepinephrine (Randt, Quartermain, Goldstein, & Anagnosti, 1971), except that the effect of these drugs is to impair rather than facilitate retention.…”

Section: A Neural Arousalmentioning

confidence: 77%

Electroconvulsive Shock and Memory

Schneider

1983

The Physiological Basis of Memory

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“…For example, recovery of memory in cycloheximide (CXM)-treated mice following pretest treatment with MAO inhibitors was accompanied by autonomic signs of fear, such as piloerection, urination, and defecation (Botwinick & Quartermain, 1974). In such experiments it is difficult to distinguish recovery of memory from nonspecific depressant effects, and absence of recovery may be masked by increases in general activity or arousal when agents such as amphetamine are employed.…”

Section: B Behavioral Controlsmentioning

confidence: 99%