Recovery effect of pre-germinated brown rice on the changes of sperm quality, testicular structure and androgen receptor expression in a rat model of drug addiction

Thanoi, Samur; Roboon, Jureepon; Nudmamud-Thanoi, Sutisa

doi:10.7150/ijms.26076

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…This evidence indicates the powerful adverse effect of METH on testicular function. Interestingly, the changes of sperm quality and the expression of androgen receptor in Leydig cells was found in a rat model of addiction after the administration of GABA and a GABA-containing food supplement 11 . Thus, this study proposed to investigate the alterations of GABAergic measures in the testis of METH-administered rats.…”

Section: Introductionmentioning

confidence: 99%

GABAergic Alterations in the Rat Testis after Methamphetamine Exposure

2018

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Gamma-aminobutyric acid (GABA), GABA-A receptors and GABA transporter 1 (GAT1) were reported to be involved in the proliferation of Leydig cells, testosterone production and spermatogenesis. Since methamphetamine (METH) has been reported to have adverse effects on testis and its functions, the aim of this study was therefore to determine the changes of GABAergic activity in testis after METH exposure. Male Sprague-Dawley rats were divided into control, acute binge (AB-METH), escalating dose (ED METH) and escalating dose-binge (ED-binge METH) groups. After sacrifice, rat testes were removed and used to estimate GABA concentration and the expression of GABA-A receptor, GAD1, GAD2 and GAT1 genes by using HPLC and RT-PCR, respectively. The GABA concentration was significantly increased in all METH-administrated groups. In addition, significant increases of GABA-A α1 receptor and GAD1 genes expression were found in the ED-binge METH group. Gene expressions of GAT1 were numerically decreased in all METH-administrated rats and reached significant in the ED METH group. These results indicated a compensatory upregulation of GABA production and its functions in testis after METH exposure. Thus, these changes might represent a homeostatic response of GABAergic to the adverse effects of METH.

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Section: Introductionmentioning

confidence: 99%

GABAergic Alterations in the Rat Testis after Methamphetamine Exposure

2018

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“… 2016 ; Thanoi et al. 2018 ). In this study, CS caused germ cell degenerations but Sertoli cells still existed within the seminiferous tubules as demonstrated in histological figures.…”

Section: Discussionmentioning

confidence: 99%

“… 2016 ; Thanoi et al. 2018 ). Moreover, stress caused from heat induction could induce apoptosis and decrease of AR expression in animal testis (Türk et al.…”

Section: Introductionmentioning

confidence: 99%

Seed extract of Thai Mucuna pruriens reduced male reproductive damage in rats induced by chronic stress

Lapyuneyong

Tangsrisakda

Choowong-In

et al. 2022

Pharmaceutical Biology

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Context Thai Mucuna pruriens (L.) DC. var. pruriens (Fabaceae) (TMP) is known to enrich reproduction but preventive effects on stress related adverse reproductive parameters are not documented. Objective This study investigates the protective property of TMP seed extract on reproductive damage under chronic stress (CS). Materials and methods Male Sprague-Dawley rats were divided into four groups. The control and CS groups received distilled water, whereas the pre-treated rats received the aqueous TMP seed extract at doses of 150 and 300 mg/kg BW for 20 days before co-treatments with CS induction (immobilization and forced swimming) for 81 days. Serum was used to determine the cortisol and testosterone levels. Histology of testis and epididymis was observed with localization of androgen receptor (AR). Sperm parameters and the expression of steroidogenic acute regulatory (StAR), cytochrome P450 family 11 subfamily a member 1 (CYP11A1), AR, HSP70, caspases (3 and 9) and tyrosine phosphorylation (TyrPho) proteins were investigated. Results TMP extract improved cortisol level (0.84 ± 0.02 µg/dL) and protected against the damage of reproductive tissues and sperm parameters (count [49.78 ± 3.74 million sperm/mL], viability [90.01 ± 1.17%] and precocious acrosome reaction [1.38 ± 0.48%]). Expression of testicular StAR, CYP11A1, AR and HSP70 proteins was improved. Caspase expression was decreased in treated rats. TMP increased AR expression in CS sperm. Moreover, TyrPho protein expression was corrected after TMP administration. Conclusions TMP seed protected against adverse reproductive parameters in CS via improvements of functionally testicular markers and reductions of apoptotic proteins. It is possible to develop the TMP beans as an alternative medicine in treating of male subfertility caused by CS.

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“…After the brown rice is germinated, the starch is degraded into sugar, thus increasing the sweetness and flavor, solving the problem of unpleasantness of brown rice, and the physiological active ingredients in brown rice, such as dietary fiber, total phenolic acid, vitamins, reducing sugar, amino acids, trace amounts. Both elements and neurotransmitters are significantly increased before germination, especially neurotransmitters have blood pressure lowering, improved brain function, mental stability, promotion of long-term memory, promotion of growth hormone secretion, activation of renal function, activation of liver function, beauty, sobering, etc [51]. Therefore, improving the utilization value of brown rice through the germination process can not only improve the utilization efficiency of rice resources, but also improve the nutritional and dietary levels of people.…”

Section: Germinated Brown Ricementioning

confidence: 99%

Deep Processing of Rice and Comprehensive Utilization of Its By-products

Wen¹,

Ma²,

Lin³

et al. 2019

JFNR

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China is a big country in the production and consumption of rice in the world. However, for a long time, China's rice processing is only in the primary processing state that meets people's demand for rations, and the level of comprehensive utilization of deep processing and its by-products is low. This paper reviews the main raw and byproducts of rice, such as rice protein, rice starch and by-products of rice processing (including broken rice, rice bran and rice husk), aiming to further improve the comprehensive utilization of rice resources and increase the added value of rice and its by-products to create more economic and social benefits. The vigorously developing and promoting the deep processing technology of rice and its by-products will extend the rice industry chain and greatly increasing the added value of rice, make full use of resources to supplement the shortage of high-quality edible oil, protein, starch and other products.

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Recovery effect of pre-germinated brown rice on the changes of sperm quality, testicular structure and androgen receptor expression in a rat model of drug addiction

Cited by 4 publications

References 27 publications

GABAergic Alterations in the Rat Testis after Methamphetamine Exposure

GABAergic Alterations in the Rat Testis after Methamphetamine Exposure

Seed extract of Thai Mucuna pruriens reduced male reproductive damage in rats induced by chronic stress

Deep Processing of Rice and Comprehensive Utilization of Its By-products

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