Recovery and purification of acetic acid from aqueous mixtures by simulated moving bed adsorption with methanol and water as desorbents

Santos, Dora Lucía Uribe; Dobladez, José Antonio Delgado; Águeda, V.I.; Torrellas, Silvia Álvarez; Larriba, Marcos

doi:10.1016/j.seppur.2019.116368

Cited by 14 publications

(3 citation statements)

References 22 publications

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“…( AZEVEDO and RODRIGUES, 2006;URIBE SANTOS et al, 2020). A adsorção não gera subprodutos negativos como outros processos químicos de modo que é relativamente fácil operar sem se preocupar com a poluição.…”

Section: Lista De Tabelaunclassified

Estudo Sobre Equações Para Quantidade Adsorvida E Concentração Na Superfície Da Partícula Em Adsorção Com Modelo De Difusão

Zhang¹,

Silva²

2022

Anais Do(a) Anais Do Congresso Brasileiro Interdisciplinar Em Ciência E Tecnologia

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The current work provides kinetic analysis and new equations in adsorption equilibrium process of phenanthrene and pyrene with diffusion model in order to solve partial differential equations problem that integrates the phenomenon of external diffusion mass transfer in the intraparticle layer. The methods are based on the form of solutions and appropriate hypotheses to establish as equations of adsorbed quantity and concentration at the surface of the adsorbed particle. Two unknown functions were evaluated, one related to the concentration function in the liquid (CL) and the other S(t)ϕ(t) the amount adsorbed in time. The parameters E1, 1, E2, 2, were first determined when two sets of experimental data were applied, in which the subscript index 1 represents the modified zeolite adsorbent and the index 2 represents the sepiolite adsorbent. Next, the proposed equations were evaluated by the statistical indicators, which showed the goodness-of-fit. Especially, zeolite has more suitable indicators value. Based on the evaluated equations, the mass transfer coefficients ke1, De1, ke2, De2 are determined respectively in order to obtain a dimensionless Biot number. As a result, modified Zeolite adsorbent presents the best adsorption quality in comparison with Sepiolita. The limiting step determined by Biot in the end highlights the diffusion in the pores in the case of zeolite and external diffusion in the boundary layer in the sepiolite.

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Section: Lista De Tabelaunclassified

Estudo Sobre Equações Para Quantidade Adsorvida E Concentração Na Superfície Da Partícula Em Adsorção Com Modelo De Difusão

Zhang¹,

Silva²

2022

Anais Do(a) Anais Do Congresso Brasileiro Interdisciplinar Em Ciência E Tecnologia

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“…SMB improves the utilization of the stationary phase by achieving loadings much closer to the static (maximum) binding capacity of the resin in comparison to batch chromatography and reduces column volume – thereby adding to the intensification effect 6 . SMB chromatography has been applied to continuous purification of carbohydrates, carboxylic and organic acids, proteins, viruses and monoclonal antibodies (mAbs) 5‐12 …”

Section: Adsorption and Chromatographymentioning

confidence: 99%

Perspectives on adsorption technology as an effective strategy for continuous downstream bioprocessing

Schneider

Herlevi

Guo

et al. 2021

J of Chemical Tech & Biotech

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The biological industry, but also biorefining platforms in the context of the circular economy, have been fertile terrains for the development of a palette of novel products of increasing structural diversity and fields of application. To mention only a few of the more complex bioproducts, we can consider monoclonal antibodies, plasmid DNA, virus‐like particles and exosomes. Of course, some products of industrial relevance are much simpler in nature. Irrespective of the product class and field of application, a shift from batch processing to continuous manufacturing is currently happening. This is due to the fact that operating in the continuous mode can result in process intensification, and therefore increased productivity with lower environmental impact can be realized. Some biological production schemes, e.g. those based on perfusion cultures, are well known in the pharmaceutical industry. Likewise, continuous fermentation is now utilized to produce ethanol from biomass. In many cases, continuous downstream operations are desired but difficult to implement; there is a pressing need to better understand the available options for product recovery and purification. Some traditional methods require re‐evaluation in modern contexts and some others, of experimental nature, require further improvement before actual implementation. In this article, we present an overview of the most promising methods that would allow for robust downstream bioprocessing options in the near future – with a focus on adsorption technologies. © 2021 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).

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“…Li et al [ 24 ] investigated the feasibility of xylo‐oligosaccharides purification by sequential simulated moving bed (SSMB). Uribe Santos et al [ 25 ] obtained acetic acid with recovery over 95% and purity over 99% from aqueous mixtures by SMB. Lee et al [ 26 ] comprehensively optimized a BD‐isomer separation SMB.…”

Section: Introductionmentioning

confidence: 99%

Purification of rutin by supercritical fluid simulated moving bed chromatography

Geng

Yang

et al. 2021

Can J Chem Eng

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Recent studies have shown that rutin (Quercetin‐3‐O‐rhamnosylglucoside) may have an inhibitory effect on COVID‐19. Rutin can be extracted from Tartary buckwheat as an active pharmaceutical ingredient. Nevertheless, its purification is mainly hindered by Kaempferol‐3‐O‐rutinoside (K3R) due to their similar molecular structures. This study intends to propose a simulated moving bed (SMB) chromatography process of rutin and K3R to achieve continuous production. True moving bed (TMB) and SMB models were established to numerically analyze and optimize this process. The system consists of a four‐zone SMB with two columns in each zone. The effects of the switch interval, feed flowrate, desorbent flowrate, extract flowrate, raffinate flowrate, and recycle flowrate on the purity and yield of rutin and K3R were investigated and the optimized conditions were chosen as 5 min, 3.5, 40, 34, 9.5, and 24.5 L/min, respectively. Consequently, the purities of 99.64% and 99.25%, and the yields of 99.81% and 99.37% for rutin and K3R were obtained, respectively. The simulation results can provide a guidance for the future industrial application of SF‐SMB to separate rutin and K3R.

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Recovery and purification of acetic acid from aqueous mixtures by simulated moving bed adsorption with methanol and water as desorbents

Cited by 14 publications

References 22 publications

Estudo Sobre Equações Para Quantidade Adsorvida E Concentração Na Superfície Da Partícula Em Adsorção Com Modelo De Difusão

Estudo Sobre Equações Para Quantidade Adsorvida E Concentração Na Superfície Da Partícula Em Adsorção Com Modelo De Difusão

Perspectives on adsorption technology as an effective strategy for continuous downstream bioprocessing

Purification of rutin by supercritical fluid simulated moving bed chromatography

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