Recovery after brain damage: Is there any indication for generalization between different cognitive functions?

Richter, Kim Merle; Mödden, Claudia; Hanken, Katrin; Hildebrandt, Helmut

doi:10.1080/13803395.2015.1030358

Cited by 5 publications

(3 citation statements)

References 33 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the World Health Organization, the incidence of TBI has been consistently increasing and is expected to surpass many diseases and disorders as a leading cause of death and disability by the year 2020 (Hyder et al, 2007). While many patients exhibit deficits in motor performances, the most prolonged symptoms tend to be cognitive impairments such as learning deficits and memory loss (Horneman and Emanuelson, 2009; Levin et al, 2010; Barry and Tomes, 2015; Richter et al, 2015). A patient’s quality of life is certainly impaired by these dysfunctions and the costs of managing these symptoms account for billions of dollars each year (Max et al, 1991; Selassie et al, 2008; Faul et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Abbreviated environmental enrichment confers neurobehavioral, cognitive, and histological benefits in brain-injured female rats

Radabaugh

Carlson

O’Neil

et al. 2016

Experimental Neurology

View full text Add to dashboard Cite

Environmental enrichment (EE) promotes behavioral recovery after experimental traumatic brain injury (TBI). However, the chronic rehabilitation provided in the laboratory is not analogous to the clinic where physiotherapy is typically limited. Moreover, females make up approximately 40% of the clinical TBI population, yet they are seldom studied in brain trauma. Hence, the goal of this study was to test the hypothesis that abbreviated EE would confer neurobehavioral, cognitive, and histological benefits in brain injured female rats. Anesthetized rats received a cortical impact of moderate severity (2.8 mm tissue deformation at 4 m/s) or sham injury and then were randomly assigned to groups receiving standard (STD) housing or 4-hr, 6-hr, or 24-hr of EE daily. Motor function (beam-balance/walk and rotarod) was assessed on post-operative days 1-5 and every other day from 1-19, respectively. Spatial learning/memory (Morris water maze) was evaluated on days 14-19, and cortical lesion volume was quantified on day 21. No statistical differences were appreciated among the sham controls in any assessment and thus the data were pooled. All EE conditions improved motor function and memory retention, but only 6-hr and 24-hr enhanced spatial learning relative to STD (p < 0.05). Moreover, EE, regardless of duration reduced cortical lesion volume (p < 0.05). These data confirm that abbreviated EE confers robust neurobehavioral, cognitive, and histological benefits in TBI female rats, which supports the hypothesis and strengthens the utility of EE as a pre-clinical model of neurorehabilitation.

show abstract

Section: Introductionmentioning

confidence: 99%

Abbreviated environmental enrichment confers neurobehavioral, cognitive, and histological benefits in brain-injured female rats

Radabaugh

Carlson

O’Neil

et al. 2016

Experimental Neurology

View full text Add to dashboard Cite

show abstract

“…However, attention is also often impaired post-stroke, yet no studies to our knowledge have investigated the role of attention in non-canonical sentence comprehension. Attention, particularly attentional control, and working memory abilities often correlate in neurotypical adults (Kane, Bleckley, Conway, & Engle, 2001) but are known to dissociate in stroke patients (Peers et al, 2018;Richter, Mödden, Hanken, & Hildebrandt, 2015), likely due to different lesion patterns within the distinct but overlapping brain regions that support attention and working memory (Cabeza, Daselaar, Dolcos, Prince, Budde, & Nyberg, 2004;Gazzaley, & Nobre, 2012;Wallis, Stokes, Cousijn, Woolrich, & Nobre, 2015). Thus, the effects of non-canonical sentence structures on the cognitive resources involved in sentence comprehension remain poorly defined.…”

Section: Introductionmentioning

confidence: 99%

The effects of prosody on sentence comprehension: evidence from a neurotypical control group and seven cases of chronic stroke

et al. 2019

View full text Add to dashboard Cite

Manipulations of both prosody and sentence structure (e.g., canonical versus non-canonical) can affect sentence comprehension. However, few previous studies have examined a possible interaction between prosody and sentence structure and effects on sentence comprehension, despite previous work indicating that prosodic cues assist in sentence comprehension by interacting with some of the same cognitive resources recruited to support comprehension of difficult sentence structures. In Experiment 1, we investigated whether typical sentence prosody and list prosody differentially affect the comprehension of non-canonical sentences compared to canonical sentences in adult control subjects. We found a significant interaction: typical sentence prosody facilitated the comprehension of some but not all canonical and non-canonical sentence structures. In Experiment 2, we examined in seven chronic stroke patients how some cognitive abilities may be related to the effects of prosody on sentence comprehension. Working memory was significantly correlated with comprehension of non-canonical sentences spoken with list prosody, but not with sentence prosody; attentional control did not significantly correlate with performance on sentences with either prosody type. But, single-case Bayesian statistics indicate that impaired attentional control may be related to impaired performance on sentences with sentence prosody but not list prosody, and that impaired working memory may be related to impaired performance on sentences with list prosody, but not sentence prosody. Our results suggest prosody may particularly aid comprehension of some sentence structures, and that impairments of non-canonical sentence comprehension in stroke patients may be modulated by the type of prosody used, based on a patient's relative cognitive abilities.

show abstract

“…Through many convoluted mechanisms including both the injury caused by the primary initial impact and the damaging secondary and tertiary pathophysiological cascades that follow (Kline et al, 2016; Adelson et al, 1998; Bayir et al, 2009; Bramlett et al, 2016; Carlson et al, 2017), TBIs induce a wide variety of long-lasting symptoms including motor deficiencies (Kline et al, 1994; Blaya et al, 2014; Shear et al, 2015), disrupted cognitive function (Horneman and Emanuelson, 2009; Levin et al, 2010; Barry and Tomes, 2015; Richter et al, 2015), and fatigue (LaChapelle and Finlayson, 1998). While public awareness has increased regarding the dangers of TBI, the affective and economic costs of TBIs remain astronomical and effective treatment strategies are scarce (Doppenberg et al, 2004; Menon, 2009).…”

Section: Introductionmentioning

confidence: 99%

Refining environmental enrichment to advance rehabilitation based research after experimental traumatic brain injury

Radabaugh

LaPorte

Greene

et al. 2017

Experimental Neurology

View full text Add to dashboard Cite

The typical environmental enrichment (EE) paradigm, which consists of continuous exposure after experimental traumatic brain injury (TBI), promotes behavioral and histological benefits. However, rehabilitation is often abbreviated in the clinic and administered in multiple daily sessions. While recent studies have demonstrated that a once daily 6-hr bout of EE confers benefits comparable to continuous EE, breaking the therapy into two shorter sessions may increase novelty and ultimately enhance recovery. Hence, the aim of the study was to test the hypothesis that functional and histological outcomes will be significantly improved by daily preclinical neurorehabilitation consisting of two 3-hr periods of EE vs. a single 6-hr session. Anesthetized adult male rats received a controlled cortical impact of moderate-to-severe injury (2.8 mm tissue deformation at 4m/s) or sham surgery and were then randomly assigned to groups receiving standard (STD) housing, a single 6-hr session of EE, or two 3-hr sessions of EE daily for 3 weeks. Motor function (beam-balance/traversal) and acquisition of spatial learning/memory retention (Morris water maze) were assessed on post-operative days 1–5 and 14–19, respectively. Cortical lesion volume was quantified on day 21. Both EE conditions improved motor function and acquisition of spatial learning, and reduced cortical lesion volume relative to STD housing (p < 0.05), but did not differ from one another in any endpoint (p > 0.05). The findings replicate previous work showing that 6-hr of EE daily is sufficient to confer behavioral and histological benefits after TBI and extend the findings by demonstrating that the benefits are comparable regardless of how the 6-hrs of EE are accrued. The relevance of the finding is that it can be extrapolated to the clinic and may benefit patients who cannot endure a single extended period of neurorehabilitation.

show abstract

Recovery after brain damage: Is there any indication for generalization between different cognitive functions?

Abstract: Significant recovery in impaired cognitive domains can be expected during neuropsychological rehabilitation. It depends more or less exclusively on improvement in the specific functions itself, and there was no evidence for generalization between cognitive domains.

Cited by 5 publications

References 33 publications

Abbreviated environmental enrichment confers neurobehavioral, cognitive, and histological benefits in brain-injured female rats

Abbreviated environmental enrichment confers neurobehavioral, cognitive, and histological benefits in brain-injured female rats

The effects of prosody on sentence comprehension: evidence from a neurotypical control group and seven cases of chronic stroke

Refining environmental enrichment to advance rehabilitation based research after experimental traumatic brain injury

Contact Info

Product

Resources

About