For the first time, the Generalized Gamma Burr III (GGBIII) is introduced as an important model for problems in several areas such as actuarial sciences, meteorology, economics, finance, environmental studies, reliability, and censored data in survival analysis. A review of some existing gamma families have been presented. It was found that the distributions cannot exhibit complicated shapes such as unimodal and modified unimodal shapes which are very common in medical field. The Generalized Gamma Burr III (GGBIII) distribution which includes the family of Zografos and Balakrishnan as special cases is proposed and studied. It is expressed as the linear combination of Burr III distribution and it has a tractable properties. Some mathematical properties of the new distribution including hazard, survival, reverse hazard rate function, moments, moments generating function, mean and median deviations, distribution of the order statistics are presented. Maximum likelihood estimation technique is used to estimate the model parameters and applications to real datasets in order to illustrate the usefulness of the model are presented. Examples and applications as well as comparisons of the GGBIII to the existing Gamma-G families are given.