Recording the Corpus Cavernosum Electromyogram: Principles and Problems

Scheepe, Jeroen R.; Jünemann, K. P.; Bührle, Christian; Schmidt, P. H.; Wipfler, G.; Berle, Beatrice Bishop; Alken, P.

doi:10.1016/s0022-5347(01)66112-3

Cited by 9 publications

(8 citation statements)

References 4 publications

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“…1. It is noted that most activity is concentrated at the very low rangebetween 0 and 1 Hz, as expected from previous reports [10,17]. The small peak at 1.3 Hz represents the artefact of the artificial ventilator.…”

Section: Resultssupporting

confidence: 87%

“…In a previous report our group found that some of the activity recorded from the human penis represents in part systemic sympathetic activity, probably not of smooth muscle origin; therefore, only part of the activity recorded from the penis can be attributed to smooth muscle [16]. Recently Scheepe et al [10] published the first report on recording of animal smooth muscle EMG, using needle recordings from dogs. In their report, minute changes in the raw signal and in the spectral analysis in response to pharmacological interventions were qualitatively noted.…”

Section: Discussionmentioning

confidence: 98%

“…Papaverin causes relaxation of smooth muscle by activation of cGMP leading to a decrease of the intracellular calcium concentration. Similarly, cGMP-specific phosphodiesterase inhibitors such as IBMX facilitate the effect of nitric oxide on cGMP to reduce the intracellular calcium concentration [2,3,10,12]. Injection of these agents induced erection though relaxation of smooth muscles.…”

Section: Discussionmentioning

confidence: 99%

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Electrical activity from rat corpora is affected by pharmacological but not mechanical intracorporal manipulation

Vardi

Bernabé

Dashkovsky³

et al. 1998

Pfl�gers Archiv European Journal of Physiology

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Smooth muscle electromyographic (EMG) recording from the corpora cavernosa is a potentially useful clinical tool for the diagnosis of impotence. Controversy still exists regarding the nature of this signal, which could be resolved using animal models. The signal recorded from denuded rat corporal surface was Fourier transformed, and power at 0.01-1 Hz was calculated. Measurements were taken in the flaccid state and during erection induced by intracorporal injection of smooth muscle relaxants [the phosphodiesterase inhibitors papaverin and isobutylmethylxanthine (IBMX)]. Recorded activity decreased significantly during the pharmacologically evoked erection: the mean square root power of 250.7+/-137.1 microV decreased to 49.8+/-14.1 microV (P<0.0001) after papaverin, and IBMX caused it to decrease from 222.8+/-132.0 microV to 58.1+/-40.8 microV (P<0.0001) (mean +/- SD). Intracorporal injection of adrenaline partially reversed the response, increasing activity to 135.3+/-72.3 microV (P=0.01) and 137.5+/-122.6 microV (P=0.015), respectively, in parallel with detumescence. In order to rule out a mechanical artefactual explanation for these results, recording was also performed before and during artificial erection induced by the intracorporal infusion of saline. This manipulation did not cause any change in corporal activity, despite corporal engorgement and increased pressure. In conclusion, the signal indeed reflects changes in the tone of corporal smooth muscle, and therefore should be regarded as a genuine EMG recording.

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Section: Resultssupporting

confidence: 87%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Electrical activity from rat corpora is affected by pharmacological but not mechanical intracorporal manipulation

Vardi

Bernabé

Dashkovsky³

et al. 1998

Pfl�gers Archiv European Journal of Physiology

View full text Add to dashboard Cite

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“…2 To date, results from only one experimental animal model of electrical activity of corporal smooth muscle have been published. 8 This article deals with the qualitative properties of the signal only.…”

mentioning

confidence: 99%

Smooth muscle electromyography from rat urethra

Yarnitsky¹,

Dashkovsky²,

Rogovsky³

et al. 1997

Muscle Nerve

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Electrical signals recorded from the penis have been suggested as reflecting electromyographic activity in the underlying smooth muscles. In order to verify this assertion, we manipulated the signal recorded from rat urethra surface. Stimulation of the pelvic nerve brought about a reduction of activity (965 ± 826 to 166 ± 143 μV, root mean square of the power at range 0.005–1 Hz, P = 0.008), with a significant frequency‐response relationship (P = 0.0002). This effect was not altered by temporary closure of the aorta (P = 0.89), thus ruling out hemodynamic artifact as a possible cause of signal change during stimulation. Our findings support the assertion that the signal indeed reflects activity in smooth muscle. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 1497–1501, 1997

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“…These measurement data are used to form the basis of the diagnosis 66 program. Initial attempts at mathematic representations were based on algorithms using the frequency domain [5,7,11,15]. Since a physician's diagnosis in clinical routine is normally reached using the time domain, a computer's result description based on frequency parameters would cause a high degree of abstraction.…”

mentioning

confidence: 99%

Computer-assisted interpretation of electromyograms of corpora cavernosa using fuzzy logic

et al. 1997

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An electromyogram of the corpora cavernosa (CC-EMG) imparts information on the autonomic cavernous innervation and/or the cavernous smooth muscles. The CC-EMG is interpreted mainly by evaluation of signal patterns of higher activity. The time required for interpretation is reduced by the implementation of a computer-assisted diagnosis program with a Microsoft Windows user interface. The program offers four levels of diagnosis: on the first level, recordings can be edited; on the second and third levels, signal patterns can be searched or evaluated; and on the last level the final diagnosis is provided. The computer-assisted interpretation is based on digital measurement data. These data have been obtained through a 170.6-Hz sampling frequency and a quantization of 10 V/12 Bit of the amplified signal. The first task of this diagnosis program is to discover and extract signal patterns of higher activity from data stored on the hard disk of a personal computer (PC). For a mathematic description of these patterns the following features were defined: relative time position, relative reproducibility, part of normal phases, and part of whip phases. Syntactic pattern recognition was introduced to identify the characteristic signal forms. An evaluation of the patterns could be derived from these features using fuzzy logic. For a summary of the evaluated patterns the variable global normality was established. The global normality forms an important evaluation basis along with the global synchronism, which represents an investigator's first impression of a recording. The final diagnosis is completed using fuzzy logic. The program was tested by comparison of expert and computer diagnoses. A total of 30 records were independently evaluated by an expert team and the computer program. With reference to the four classified levels of diagnosis a correspondence of 70% could be found. Furthermore, the rate in each of the classified levels was higher than 50%. The discrimination between normal and abnormal evaluation was 80% for clinical routine. Our results show that a computer-assisted interpretation of the CC-EMG can be achieved using mathematically based software. Within the last 7 months this computer-assisted CC-EMG program proved to be of great help in routine diagnosis. Furthermore, it demonstrated results comparable with a blinded-expert interpretation. This approach should bring about dramatic improvements in the diagnosis of erectile dysfunction.

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Recording the Corpus Cavernosum Electromyogram: Principles and Problems

Abstract: Our findings indicate that electromyograms from the corpus cavernosum can be recorded even under adverse conditions. Signal properties, however, are such that the application of computer-aided data processing and analysis to the evaluation of these myograms is imperative.

Cited by 9 publications

References 4 publications

Electrical activity from rat corpora is affected by pharmacological but not mechanical intracorporal manipulation

Electrical activity from rat corpora is affected by pharmacological but not mechanical intracorporal manipulation

Smooth muscle electromyography from rat urethra

Computer-assisted interpretation of electromyograms of corpora cavernosa using fuzzy logic

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